Results 71 to 80 of about 760,836 (304)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Product Innovations in the Manafacturing Processes of Special Composites

Littera Scripta, 2017
At present, in order to maintain a sustainable production process and achieve real business competitiveness, attention needs to be paid focused planning of innovations in production systems. Major innovations are the product innovations where significant
Eva Ružinská
doaj  

Crucial aspects for maintaining rAAV stability

Scientific Reports
The storage of rAAV vectors for gene therapy applications is critical for ensuring a constant product quality and defined amount of medication at the time of administration.
Johannes Lengler, Mia Gavrila, Janina Brandis, Kristina Palavra, Felix Dieringer, Sabine Unterthurner, Felix Fuchsberger, Barbara Kraus, Juan A. Hernandez Bort   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Monopoly, Diversification through Adjacent Technologies, and Market Structure [PDF]

The theoretical literature on technological competition has been mostly concerned with various aspects of innovative activity in a single market.
Karaaslan, Mehmet E.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A global collaboration to advance vaccine product innovations - The Vaccine Innovation Prioritisation Strategy. [PDF]

Vaccine, 2021
Kristensen D, Giersing B, Hickling J, Kazi F, Scarna T, Kahn AL, Hsu V, Gandrup-Marino K, Menozzi-Arnaud M.   +8 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Decomposing Productivity Growth in the U.S. Computer Industry [PDF]

In this paper, we examine the sources of the productivity growth in the U.S. computer industry from 1978 to 1999. We estimate a joint production model of output quantity and quality that distinguishes two types of technological changes: process and ...
Chun, H., Nadiri, M.I.
core   +3 more sources

THE IMPACT OF PRODUCT AND PROCESS INNOVATION AND TECHNOLOGICAL DIMENSIONS ON THE SUSTAINABLE COMPETITIVE ADVANTAGE OF MANUFACTURING COMPANIES

Ekonomika Poljoprivrede (1979)
This study investigates the impact of product, process, and technological innovations on the sustainable competitive advantage of manufacturing companies. An empirical survey was conducted on a sample of 252 employees.
Dragana Vuković, Ana Dukić, Ana Urošević, Božo Ilić   +3 more
doaj   +1 more source