Results 81 to 90 of about 3,167,450 (250)
Possibilities of innovative development of the company in business model construction
Путеводитель предпринимателя, 2020 Innovations are connected about uncertainty and risk as the effect from their introduction has, as a rule, long-term character and is connected with bigfinancial expenses.
M. A. Yakhjyaev, B. R. Shakirtkhanov
doaj
Environmental innovations and sustainability practices of manufacturing firms in Uganda [PDF]
Asia Pacific Journal of Innovation and EntrepreneurshipPurpose – The purpose of this study is to investigate the pivotal role of environmental innovations in driving sustainability practices within medium and large manufacturing firms operating in Uganda. Design/methodology/approach – Using a cross-sectional
Kassim Alinda +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
"Silver" product design: Product innovation for older people [PDF]
Aging populations challenge companies across different countries and industries to respond to the changing needs, demands and expectations of their growing shares of older customers.
Herstatt, Cornelius +2 more
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Russian Journal of Economics and Law, 2011 The work specifies the apparatus criticus of elaboration of ecology-oriented technological innovations, presents the topical types and techniques of assessment of product and procedural ecology-oriented innovations, improves the model of forming product ...
E. Shaimiyeva
doaj
IMPACT OF INNOVATIONS ON THE PRODUCT MARKET COMPETITIVE DEVELOPMENT
International Journal of Innovative Technologies in Economy, 2018 Competitive product markets are characterized by aiming at complete consumers’ needs satisfaction, flexible market price making, freedom of economic activity and entrepreneurship, free entry and exit from a market, fair trading and business practices etc.
Zhanna Poplavska +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Do Spillovers Stimulate Incremental or Drastic Product Innovations? Hypotheses and Evidence from German Establishment Data [PDF]
We estimate the determinants of various types of product innovation. Knowledge spillovers from rivals have a positive impact on incremental innovations. This impact is largely independent of the participation in R&D cooperations. Spillovers exert no such
Jirjahn, Uwe, Kraft, Kornelius
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Product Innovation and Growth: The Case of Integrated Circuits. [PDF]
Applied research on growth and innovation seems to suggest that successful innovations do not significantly enhance firm growth. This paper tests the hypothesis that the level of observation at which applied research is typically conducted hampers ...
Marco Corsino
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