Results 81 to 90 of about 103,011 (308)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Process and Product Innovations: Complements or Substitutes?
, 2010 This paper analyzes rms simultaneous choice in the intensity of process and product innovations, in market with vertical prod- uct di¤erentiation. Considering both monopoly and oligopoly models, we show that di¤erent shocks on the demand and cost ...
Tedeschi, Piero
core
Bridging the gap between design and behavioral research: (Re)searching the optimum design strategy for brands and new product innovations [PDF]
, 2020 Innovation, branding, and design are known to affect corporate success, but their interplay is not yet well understood. Companies need to take risks in developing new product innovations, whereas an established brand can serve as a familiar base to ...
Mulder-Nijkamp, Maaike +1 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Enterprise systems and innovations [PDF]
This paper analyzes the relationship between the three main enterprise systems (Enterprise Resource Planning (ERP), Supply Chain Management (SCM), Customer Relationship Management (CRM)) and firms' innovational performance.
Engelstätter, Benjamin
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Product Innovations in the Manafacturing Processes of Special Composites
Littera Scripta, 2017 At present, in order to maintain a sustainable production process and achieve real business competitiveness, attention needs to be paid focused planning of innovations in production systems. Major innovations are the product innovations where significant
Eva Ružinská
doaj
Ekonomika Poljoprivrede (1979)This study investigates the impact of product, process, and technological innovations on the sustainable competitive advantage of manufacturing companies. An empirical survey was conducted on a sample of 252 employees.
Dragana Vuković +3 more
doaj +1 more source
A global collaboration to advance vaccine product innovations - The Vaccine Innovation Prioritisation Strategy. [PDF]
Vaccine, 2021 Kristensen D +8 more
europepmc +1 more source