Results 51 to 60 of about 3,167,450 (250)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Managerial Recommendations for Service Innovations in Different Product-Service Systems

, 2009
In order to meet the increasingly complex needs of customers and to respond to decreasing product margins, typical product manufacturers have developed a growing interest in extending their service business. The extension of the service business requires
Gebauer, Heiko,, Fischer, Thomas,, Thomas Fischer, Lars Witell, Witell, Lars,, Fischer-Hübner, Simone,, Heiko Gebauer, Anders Gustafsson, Gustafsson, Anders,   +8 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Integrated Product Policy and Environmental Product Innovations: An Empirical Analysis [PDF]

The European Commission has recently stepped up its promotion of the ?Integrated Product Policy?. The objective of the IPP is to support the realisation of environmental product innovations and thus to achieve a broad reduction of all environmental ...
Rennings, Klaus, Ziegler, Andreas, Rehfeld, Katharina-Maria   +2 more
core  

The effect of innovation activity on innovating quasi-rents: an empirical application [PDF]

, 1998
This paper investigates whether innovations generate quasi-rents and whether the size of those quasi-rents are affected by market conditions. Using a panel data of Spanish manufacturing firms during the period 1990-93 we answer affinnatevely to both ...
Martínez-Ros, Ester, Salas-Fumás, Vicente, Martínez Ros, Ester, Salas Fumás, Vicente   +3 more
core   +1 more source

Special economic zones, gender and innovations: new evidence from an emerging economy

Cogent Business & Management
This paper examines how the gender of CEOs affect product and process innovations at the firm level, focusing on how SEZ features affect the gender-innovations nexus.
Charles Godfred Ackah, Robert Darko Osei, Baah Aye Kusi   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source