Results 41 to 50 of about 2,783,970 (303)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Comparative efficacy and safety of first-line treatments for advanced hepatocellular carcinoma: a Bayesian network meta-analysis

Frontiers in Immunology
BackgroundThe therapeutic landscape of advanced hepatocellular carcinoma (HCC) has expanded beyond sorafenib, with multiple combination regimens now demonstrating improved outcomes.
Yun Su, Yun Su, Tongze Cai, Jingxuan Wei, Qiuju Huang, Chun Yao, Chun Yao, Lei Fu, Lei Fu, Jinghui Zheng, Hongwei Guo, Xiongbin Gui   +11 more
doaj   +1 more source

Have product substitution carbon benefits been overestimated? A sensitivity analysis of key assumptions

Environmental Research Letters, 2019
Substitution of wood for more fossil carbon intensive building materials has been projected to result in major climate mitigation benefits often exceeding those of the forests themselves.
Mark E Harmon
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Does public indebtedness matter in the effect of public health expenditure on human longevity in Sub-Saharan Africa countries? Evidence from dynamic panel threshold regression

Health Economics Review
The third Sustainable Development Goal (SDG) aims to enable everyone to live in good health and to promote the well-being of all. However, despite the various efforts made to achieve this goal, sub-Saharan Africa (SSA) is still characterised by low human
Jacques Boundioa
doaj   +1 more source

Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans

Frontiers in Nutrition, 2022
Numerous studies reported that betulinic acid (BA), a natural product extracted from birch bark, exhibited various beneficial effects in vitro. However, its pharmacological activities in aging are rarely understood.
Haiyan Chen, Haiyan Chen, Rongji Li, Feng Zhao, Li Luan, Tiantian Han, Zhong Li   +6 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Efficient versus inefficient hedging strategies in the presence of financial and longevity (value at) risk [PDF]

, 2013
This paper provides a closed-form Value-at-Risk (VaR) for the net exposure of an annuity provider, taking into account both mortality and interest-rate risk, on both assets and liabilities.
Regis, Luca, Luciano, Elisa
core   +2 more sources

Heliconia ‘Golden Torch’ postharvest: stem ends cutting and renewing vase water benefits

Ornamental Horticulture, 2016
The postharvest longevity is one of the main aspects that should be considered in the production of cut flowers and is a pre-requisite for product quality and marketing success. However, cut flowers are highly perishable products that need to be treated
Wladiney Rodrigues Folha, Rafaela Ribeiro Souza, Genilda Canuto Amaral, Alcilane Arnaldo Silva, Jullyanna Nair Carvalho, Márkilla Zunete Beckmann Cavalcante   +5 more
doaj   +1 more source