Results 111 to 120 of about 2,266,224 (303)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Farm production diversity, household dietary diversity, and nutrition: Evidence from Uganda's national panel survey. [PDF]
PLoS One, 2022 Sekabira H +3 more
europepmc +1 more source
Surviving in agglomerations: Plant evolution and the changing benefits of the local environment [PDF]
Cities vary with regard to the characteristics of their economic life. A formal model by Duranton and Puga (2001) suggests a division of labour between diversified and specialized cities.
Frank Neffke +2 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Marker assisted breeding and mass selection of wheat composite cross populations [PDF]
, 2011 Utilising diverse populations instead of single line varieties is expected to lead to a number of advantages in cereal production. These include reduced epidemics of plant diseases, improved weed competition and better exploitation of soil nutrients ...
Backes, Gunter +4 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Diversity and forest productivity in a changing climate [PDF]
New Phytologist, 2018 ContentsSummary50I.Introduction50II.Drivers of the diversity–productivity relationship51III.Patterns of the diversity–productivity relationship55IV.Responses of mixed stands to climate change57V.Conclusions60Acknowledgements61References61SummaryAlthough the relationship between species diversity and biomass productivity has been extensively studied in ...
openaire +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Aztec obsidian industries [PDF]
, 2016 Obsidian was the primary lithic or stone material used for cutting activities in Aztec society, including domestic food production, craft production, hunting, warfare, and ritual.
Carballo, David M., Pastrana, Alejandro
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source