Results 111 to 120 of about 679,373 (303)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Breeding programs for indigenous chicken in Ethiopia : analysis of diversity in production systems and chicken populations

open access: yes, 2011
The aim of this research was to generate information required to establish a sustainable breeding program for improving the productivity of locally adapted chickens to enhance the livelihood of rural farmers in Ethiopia.
Dana, N.M.
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Cough-Diversity and the peripheral mechanisms of production.

open access: yesFolia Pharmacologica Japonica, 1995
The physiology and pharmacology of the cough reflex were reviewed from the perspective that the cough response and its peripheral mechanisms have diversity, taking reported findings together with the results obtained from our own studies. It is clear that there was a remarkable difference in the magnitude of expiration and sound in coughing between the
TAKAHAMA, Kazuo, MIYATA, Takeshi
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The economic analysis of product diversity [PDF]

open access: yes
Product diversity is a long-debated issue in economics. We remind that mainly two questions have been given answers : (a) To which extent does the market provide diversity ? (b) Why should this diversity be promoted ? The first one stands out as the core
Heritiana Ranaivoson
core  

Ground-Active Arthropod Diversity Under Energycane and Biomass Sorghum Production

open access: yes
Energycane and biomass sorghum are two of the most promising cellulosic energy crops in the southeastern US. Research on these two energy crops has focused mainly on biomass production, and there is a lack of knowledge on their ability to promote ...
Yubin Yang   +15 more
core   +1 more source

Amphibian diversity in Amazonian flooded forests of Peru [PDF]

open access: yes, 2015
Global biodiversity is currently facing the sixth mass extinction, with extinction rates at least 100 times higher than background levels. The Amazon Basin has the richest amphibian fauna in South America, but there remain significant gaps in our ...
Upton, Kathleen Anne
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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