Results 131 to 140 of about 2,266,224 (303)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Human Capital Spillovers in the Workplace: Labor Diversity and Productivity [PDF]

open access: yes
The paper studies the relationship between human capital spillovers and productivity using a unique longitudinal matched employer–employee dataset of Israeli manufacturing plants that contains individual records on all plant employees.
Navon, Guy
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Using Economics to Explain Spatial Diversity in a Wheat Crop: Examples from Australia and China [PDF]

open access: yes
Spatial diversity indicators may serve an important function for policymakers as they seek to manage crop genetic diversity and potential externalities associated with diffusion of some types of genetically improved crops.
Brennan, John P.   +3 more
core   +1 more source

Constraints on the optimization of gene product diversity

open access: yesMolecular Systems Biology
Abstract RNA and proteins can have diverse isoforms due to post-transcriptional and post-translational modifications. A fundamental question is whether these isoforms are mostly beneficial or the result of noisy molecular processes. To assess the plausibility of these explanations, we developed mathematical models
Daohan Jiang   +4 more
openaire   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Developing management plans for periurban degraded forests around Kinskasa (DRC) [PDF]

open access: yes, 2011
The forests of the Democratic Republic of Congo are part of the second largest tropical forest in the world. Many of the rural population of this country are located nearby and live from them.
Dubiez, Emilien   +3 more
core  

Chemical diversity of cyanobacterial natural products

open access: yesNatural Product Reports
This review article covers 995 natural products of cyanobacterial origin reported from 2010 to 2023. Compounds were analyzed using similarity networking to gain insights into their chemical diversity.
Márcio B. Weiss   +8 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Indicators of weed competition on Organic Winter Wheat [PDF]

open access: yes, 2007
Organic winter wheat production is limited by climatic and agronomic factors, including weed competition. The incidence of weeds on yield limitation can be characterized through various early indicators to predict weed occurrence and competition.
Casagrande, Marion   +3 more
core  

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