Results 151 to 160 of about 679,373 (303)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

OBSERVING CHANGES IN CANADIAN DEMAND FOR FOOD DIVERSITY OVER TIME

Research on food diversity is interdisciplinary in nature, and is highly relevant for different research fields. Eating a variety of foods has been linked to the nutritional well-being of the household. From an economic perspective, food diversity can be
Drescher, Larissa S., Goddard, Ellen W.
core  

The role of lateral connectivity in the maintenance of macrophyte diversity and production in large rivers

, 2013
1. Large European river floodplains have been intensively reduced through human activities over several millennia. Ecological assessments of natural large river systems remain rare and potentially flawed since they typically omit either the main channel ...
Willby, Nigel, Gilvear, David, Nigel J. Willby, Keruzore, Antoine A, Antoine A. Keruzoré, David J. Gilvear   +5 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Smallholder aquaculture diversifies livelihoods and diets thus improving food security status: evidence from northern Zambia

Agriculture & Food Security
Background Much has been made of the potential for aquaculture to improve rural livelihoods and food and nutrition security in Africa, though little evidence exists to back such claims.
Alexander M. Kaminski, Steven M. Cole, Jacob Johnson, Shakuntala H. Thilsted, Mary Lundeba, Sven Genschick, David C. Little   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Local Seed Markets and the Determinants of Crop Variety Diversity in Marginal Environments: The Case of Millet in Semi-Arid India

The purpose of the research paper is to characterize biological diversity related to millets in the semi-arid regions of India at various spatial scales of analysis (e.g., farm household versus community levels) and place that evidence in a broader seed ...
Nagarajan, Latha, Glewwe, Paul, Smale, Melinda   +2 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Cultural Diversity and Economic Performance: Evidence from European Regions [PDF]

We investigate the relationship between diversity and productivity in Europe using an original dataset covering the NUTS 3 regions of 12 countries of the EU15 (Austria, Belgium, Denmark, France, former Western Germany, Ireland, Italy, the Netherlands ...
Giovanni Prarolo, Dino Pinelli, Elena Bellini, Gianmarco I.P. Ottaviano   +3 more
core