Results 141 to 150 of about 8,484,068 (292)

Corner View - Model of the Diversity Center

open access: yes, 2018
A corner view of a model of the Diversity Center created by Alejandra Perez to present to a ...
Perez, Alejandra, Ashmawi, Mariam
core   +1 more source

Diversity Report 2000-2001 [PDF]

open access: yes, 2002
This document is an analysis of the Diversity Plan for the 2000-2001 academic year. Each of the objectives is defined in detail, citing examples of success from specific departments.
The Ohio State University. Council on Diversity
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Diversity Plans: an Analysis 2008-2009 [PDF]

open access: yes, 2009
This is the analysis of the 2008-2009 Diversity Action Plan, which contains an executive summary as well as audits of the participating departments and offices.
The Ohio State University. Council on Diversity
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Diversity Center Services and Activities Fees Presentation

open access: yes, 2018
Presentation by Student Assistants and Director for Diversity Center SAF proposal for 2018-2019Documents and ...
Macias Miguel
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Student Diversity Center Student Technology Fee Worksheet 2017-2018, UPDATED

open access: yes, 2018
Updated STF worksheet for diversity center funding for technology and equipmentDocuments and ...
Macias Miguel
core  

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