Results 141 to 150 of about 679,373 (303)

Agricultural Food Production Diversity and Dietary Diversity among Female Small Holder Farmers in a Region of the Ecuadorian Andes Experiencing Nutrition Transition. [PDF]

Nutrients, 2020
Melby CL, Orozco F, Averett J, Muñoz F, Romero MJ, Barahona A.   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The influence of farm production diversity on women’s dietary quality in Ethiopia

Discover Food
Malnutrition remains a significant global challenge, particularly in low- and middle-income countries, such as Ethiopia, where the great majority of smallholder farm households rely on agriculture as a crucial source of both food and income.
Temesgen Awoke Yalew, Alebel B. Weldesilassie, Stephen Thornhill, Edward Lahiff   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Ecological Distribution, Agricultural Trade Liberalization, and In Situ Genetic Diversity [PDF]

Genetic diversity in crop plants is crucial for long-term world food security. This diversity is sustained in the field primarily by poor farmers in developing countries, who receive no compensation for providing this external benefit to humankind.
James Boyce
core  

Draft Genome Resource of a Wolbachia Endosymbiont in Heterodera humuli

PhytoFrontiers
The bacterial endosymbiont Wolbachia is known to be associated with different arthropods and only two genera of plant-parasitic nematodes, Pratylenchus and Radopholus.
Lester A. Núñez-Rodríguez, Catherine L. Wram, Cedar Hesse, Inga A. Zasada   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Accurate prediction of wheat yield under combined saline water irrigation and arid stress: a comprehensive analysis of the FAO-AquaCrop model

Frontiers in Sustainable Food Systems
The AquaCrop model was calibrated and validated for durum wheat in the arid region of Biskra, Algeria. using field data from the CAZDA COSIDER farm during the 2022/2023 growing season. The wheat field was irrigated using a center pivot system with saline
Leyla Sekhri, Sabah Razi, Samir Merdaci, Fouad Sellem, Yacine Daibouche, Anton Poddubsky, Dmitry E. Kucher, Nazih Y. Rebouh, Mohamed E. Fadl   +8 more
doaj   +1 more source