Results 71 to 80 of about 8,484,068 (292)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

PGK1 enhances productive bovine herpesvirus 1 infection by stimulating β-catenin-dependent transcription

Veterinary Research
Bovine herpesvirus 1 (BoHV-1) productive infection stimulates β-catenin-dependent transcription to facilitate virus replication. Phosphoglycerate kinase 1 (PGK1), which catalyses the initial step of ATP production during glycolysis, also has a ...
Xuan Li, Wenyuan Gu, Shitao Li, Filomena Fiorito, Xiuyan Ding, Liqian Zhu   +5 more
doaj   +1 more source

Assessment of phenotypic diversity of local Algerian date palm (Phoenix dactylifera L.) cultivars

Journal of the Saudi Society of Agricultural Sciences, 2020
The Date palm is a strategic fruit crop in Algeria, which is one of the largest producers of dates in the world and contains about one thousand cultivars.
Hanane Bedjaoui, Halima Benbouza
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Productivity, agglomeration, and diversity

Investigaciones Regionales - Journal of Regional Research
This paper analyzes how territorial conditions influence the productivity of manufacturing and service firms in Ecuador. We employ multilevel models to estimate the effects of the urban population share and regional sectoral diversity on total factor productivity and labor productivity, also incorporating the moderating role of innovation.
Fernández-Sastre, Juan, Gonzalez Pillalaza, Juan Esteban   +1 more
openaire   +3 more sources

First Edition of Diversity Center Newsletter

, 2018
First Diversity Center newsletter, sent out at the beginning of 2018Documents and ...
UW Bothell Diversity Center
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A simple and rapid method for generating antibodies against bovine alphaherpesvirus 1 viral proteins through immunization with virus-infected murine cells

Biochemistry and Biophysics Reports
Bovine alphaherpesvirus 1 (BoAHV-1) infects cattle and typically results in significant economic losses for the cattle industry worldwide. Currently, antibodies targeting only a limited number of viral proteins are commercially available.
Jiayu Lin, Xiaozhen Ma, Naifan Zhang, Yue Pang, Filomena Fiorito, Xiuyan Ding, Liqian Zhu   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source