Results 81 to 90 of about 585,719 (254)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Webervirus phages exploit capsule- and O-antigen-targeting receptor-binding proteins to access diverse Klebsiella pneumoniae hosts

open access: yesmBio
Klebsiella pneumoniae frequently downregulates or completely loses its capsule. This abolishes infection by capsule-targeting phages but concomitantly may favor infection by phages that exploit non-capsular receptors.
Zixuan Ding   +10 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Study on Fish diversity and Fish production of “Moghat Reservoir Khandwa” (M.P.)

open access: yesEnvironment Conservation Journal, 2010
Khandwa is one of the districts of the state M.P. The Moghat reservoir is situated three Kilometers away in the Northwest area of Khandwa town on 210 49` 36`` N latitude and 760 20`56`` E longitudes. It is a man made reservoir built in 1897. The present
Vivek Keshre, L. K. Mudgal
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Genome Announcement: Draft Genome Assembly of Heterodera humuli Generated Using Long-Read Sequencing

open access: yesJournal of Nematology
The hop cyst nematode, Heterodera humuli, is the most common plant-parasitic nematode associated with hop worldwide. This study reports the draft genome of H.
Núñez-Rodríguez Lester A.   +3 more
doaj   +1 more source

Bacterial Diversity Stabilizes Community Productivity

open access: yesPLoS ONE, 2012
Stability is a crucial ecosystem feature gaining particular importance in face of increasing anthropogenic stressors. Biodiversity is considered to be a driving biotic force maintaining stability, and in this study we investigate how different indices of biodiversity affect the stability of communities in varied abiotic (composition of available ...
Eisenhauer, Nico   +2 more
openaire   +6 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

RON, Antonio M. de; RODIÑO, Ana Paula (ed.). Analysis of crop genetic and germplasm diversity. Basileia: Multidisciplinary Digital Publishing Institute, 2023. 536 p. DOI: 10.3390/books978-3-0365-8677-9

open access: yesNovos Cadernos NAEA
: The book Analysis of Crop Genetic and Germplasm Diversity, edited by Antonio M. De Ron and Ana Paula Rodiño, presents a collection of 33 studies exploring genetic diversity and germplasm across a range of global crops.
Thiago Costa Ferreira
doaj   +1 more source

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