Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Farmer management of production risk on degraded lands: the role of wheat genetic diversity in Tigray Region, Ethiopia [PDF]
"This paper investigates the effects of wheat genetic diversity and land degradation on risk and agricultural productivity in less favored production environments of a developing agricultural economy.
Chavas, Jean-Paul +2 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Agricultura Tropica et SubtropicaThe black scale, Parlatoria ziziphi (Lucas, 1853), is a significant citrus pest that weakens trees, reduces fruit quality, and significantly lowers production, thereby affecting profitability.
Mezerdi Farid, Gacem Kamila
doaj +1 more source
A diversificação produtiva adotada pelos produtores fa-miliares das unidades de produção do município de passo fundo ao longo do tempo – uma estratégia de sustentabilidade [PDF]
Revista IDEAS, 2013 The study intended to understand the factors that induced transformations in rural properties in the city of Passo Fundo. By proposing a model of analysis that gathered together the tools derived from theories of production systems, typologies of ...
Luiz Fernando Fritz Filho +2 more
doaj
Common bunt resistant wheat composite cross populations [PDF]
, 2013 Utilising diverse populations instead of single line varieties is expected to lead to a number of advantages in cereal production. These include reduced epidemics of plant diseases, improved weed competition and better exploitation of soil nutrients ...
Backes, Gunter +3 more
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Genetic diversity and forest reproductive material - from seed source selection to planting
iForest - Biogeosciences and Forestry, 2016 How much of genetic diversity is desirable in mass production of forest reproductive material? How mass production of forest reproductive material reduces genetic diversity?
Ivetić V +4 more
doaj +1 more source
Migration and Innovation - Does Cultural Diversity Matter for Regional R&D Activity? [PDF]
Recent theoretical research deals with economic costs and benefits of cultural diversity related to immigration. Empirical evidence regarding the impact of cultural diversity on economic performance is still scarce.
Annekatrin Niebuhr
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