Results 251 to 260 of about 5,015,647 (324)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti-Cancer Immunity Across the Lifespan. [PDF]

Immunol Rev
Bustillos CG, Peluso EM, Cha SL, Lechner MG, Su MA.   +4 more
europepmc   +1 more source

THE MEASUREMENT OF TERTIARY EDUCATION QUALITY IN INDONESIA THROUGH THE EDUCATION PRODUCTION FUNCTION MODEL AND POLICY RECOMMENDATIONS FOR QUALITY IMPROVEMENT [PDF]

, 2015
Shang Gao
openalex  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Examining Latin America's Transition to a Circular Economy for Plastics. [PDF]

Environ Manage
Rodríguez-Meza LR, Romero-Perdomo F, González-Curbelo MÁ.   +2 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

An ecological cascade links climatic variability to avian irruptions and zoonotic salmonellosis outbreaks. [PDF]

Proc Natl Acad Sci U S A
Tonelli BA, Youngflesh C, Tingley MW.
europepmc   +1 more source

Process-based modeling framework for sustainable irrigation management at the regional scale: Integrating rice production, water use, and greenhouse gas emissions

Yan Bo, Hao Liang, Tao Li, Feng Zhou
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source