Results 171 to 180 of about 19,558,547 (301)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Optimasi Biaya Produksi Bibit Udang Putih dengan Menggunakan Metode Simpleks (Studi Kasus: PT. Surya Windu Pertiwi)

, 2015
Optimization is an activity to get the best results under the given conditions. Linear programming as a method for solving optimization problems within the restrictions that are a powerful tool for decision makers to make the best decisions based on ...
Silaban, Jeprianto Pangihutan
core  

AI-aided engineering and production optimization of chimeric hetero-viral capping enzymes for mRNA vaccines. [PDF]

Sci Rep
Shahatibieke D, Tang X, Zheng X, Abulaizi A, Abula A.   +4 more
europepmc   +1 more source

Gellan Gum/Alginate Microparticles as Drug Delivery Vehicles: DOE Production Optimization and Drug Delivery. [PDF]

Pharmaceuticals (Basel), 2023
Carrêlo H, Cidade MT, Borges JP, Soares P.   +3 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Production process optimization

, 2008
This diploma thesis deals with the production process optimization. The cutting operation and the lathe-turning issue is described in this thesis. In the practical part the production process is analyzed, the designed experiment (DOE) is suggested and ...
Hejzlar, Aleš
core  

Valorization of Pineapple Crown for Carboxymethylcellulose Production: Optimization of Pulping Processes, Structural Characterization, and Potential as Seed Coating. [PDF]

Polymers (Basel)
Damião EF, Ascheri DPR, Teixeira IR, Signini R, Mota RDP, Ascheri JLR.   +5 more
europepmc   +1 more source

Modeling a Multi-Parameter Interaction of Geophysical Controls for Production Optimization in Gas Shale Systems. [PDF]

ACS Omega, 2023
Xu Y, Chang J, Liu X, Hu Z, Duan X.
europepmc   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

A simulation-based multi-objective optimization approach for production and logistics considering the production layout

, 2016
Manufacturing sectors in Sweden have a long tradition and represent a significant share of the national gross domestic product and the export values. Most of the Swedish manufacturing companies have gone through a modernization and adaptation process in ...
Urenda Moris, Matías, Syberfeldt, Anna, Ruiz Zúñiga, Enrique   +2 more
core