Results 161 to 170 of about 7,991,419 (293)

AI-aided engineering and production optimization of chimeric hetero-viral capping enzymes for mRNA vaccines. [PDF]

Sci Rep
Shahatibieke D, Tang X, Zheng X, Abulaizi A, Abula A.   +4 more
europepmc   +1 more source

Exploring Parametric and Mechanistic Differences between Expi293F^TM and ExpiCHO-S^TM Cells for Transient Antibody Production Optimization. [PDF]

Antibodies (Basel), 2023
Zhou J, Yan GG, Cluckey D, Meade C, Ruth M, Sorm R, Tam AS, Lim S, Petridis C, Lin L, D'Antona AM, Zhong X.   +11 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Valorization of Pineapple Crown for Carboxymethylcellulose Production: Optimization of Pulping Processes, Structural Characterization, and Potential as Seed Coating. [PDF]

Polymers (Basel)
Damião EF, Ascheri DPR, Teixeira IR, Signini R, Mota RDP, Ascheri JLR.   +5 more
europepmc   +1 more source

Identification, Characterization, and Production Optimization of 6-Methoxy-1H-Indole-2-Carboxylic Acid Antifungal Metabolite Produced by Bacillus toyonensis Isolate OQ071612. [PDF]

Microorganisms, 2023
El-Sayed SE, Abdelaziz NA, Ali AA, Alshahrani MY, Alshahrani MY, Alshahrani MY, Aboshanab KM, El-Housseiny GS.   +7 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Justification of the approaches to improve management strategy of the mining system based on the analysis of data on the mining of complex structural rock blocks

Записки Горного института
Long-term activity of mining enterprises causes the necessity to substantiate the strategies of management of the mining and technical system functioning in terms of improvement of ore quality control, which is determined by its change in the course of ...
Mariya V. Tsupkina, Aleksei E. Kirkov, Dmitrii A. Klebanov, Dmitrii N. Radchenko   +3 more
doaj  

Production optimization and <i>in vitro</i> evaluation of the biofunctional potential of folate from <i>Lactiplantibacillus plantarum</i>-MGKMVIT11. [PDF]

Front Microbiol
Megala G, Kavitha M.
europepmc   +1 more source

Isolation and production optimization of a novel milk-clotting enzyme Bacillus velezensis DB219. [PDF]

AMB Express, 2022
Zhang Y, Hu J, Liu X, Jiang C, Sun J, Song X, Wu Y.   +6 more
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source