Results 51 to 60 of about 495,373 (264)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Optimization of Streptomyces sp.A11 Medium Cultivation on Cyclo(Tyrosyl-Prolyl) Production Using the Response Surface Methodology [PDF]

open access: yes, 2012
The Response Surface Methodology is a three factorial design which provides the relationship between one or more measured dependent response and a number of input (independent) factors.
Rofiq , Sunaryanto
core  

Optimization of Keratinase Production and Utilization of Bacillus pumilus for Feather Degradation

open access: yes, 2020
Soil samples were collected from the feather dumped area where Bacillus pumilus was isolated and used for keratinase production and keratinolytic activity.
S. Abirami   +9 more
core   +1 more source

Energy efficiency and productivity improvements analysis in a Brazilian steel plant: simulation model using JaamSim open source software

open access: yesDiscover Energy
The Brazilian steel sector, inserted in a scenario of crisis and competitiveness, is going through a moment when optimization procedures in the production process are well regarded.
Rodrigo de Paula Oliveira   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Unilateral contact and damage analysis in masonry arches

open access: yesVietnam Journal of Mechanics, 2009
In the present work the ultimate failure load and the collapse mechanism of a stone arch bridge are estimated by the usage of (a) a multi - part elastic model with unilateral contact frictional interfaces and (b) a continuous damage model.
M. Campo   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

An optimization model for energy-efficient machining for sustainable production

open access: yes, 2019
Sustainable production plays an important role in product lifecycle management by considering the social sustainability. Energy-efficient machining is an efficient approach for sustainable production in current manufacturing sectors.
Wang, H   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Ecological optimization of biomass and lipid production by microalgae [PDF]

open access: yes, 2012
Microalgae have higher growth rates and higher lipid content than terrestrial plants and the yield per unit area is even higher by several orders of magnitude.
Stockenreiter, Maria
core  

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