Results 61 to 70 of about 7,991,419 (293)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Energy efficiency and productivity improvements analysis in a Brazilian steel plant: simulation model using JaamSim open source software

Discover Energy
The Brazilian steel sector, inserted in a scenario of crisis and competitiveness, is going through a moment when optimization procedures in the production process are well regarded.
Rodrigo de Paula Oliveira, Wilson Trigueiro de Sousa Júnior, Roberta Alves, Alexandre Ferreira de Pinho, Helio Tavares de Sá Neto   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Unilateral contact and damage analysis in masonry arches

Vietnam Journal of Mechanics, 2009
In the present work the ultimate failure load and the collapse mechanism of a stone arch bridge are estimated by the usage of (a) a multi - part elastic model with unilateral contact frictional interfaces and (b) a continuous damage model.
M. Campo, G. A. Drosopoulos, G. E. Stavroulakis   +2 more
doaj   +1 more source

Production of biodiesel from Sterculia foetida and its process optimization [PDF]

, 2013
The diminishing supply of fossil fuels reserves and the environmental concerns have made renewable energy an alternative energy source for the future. Sterculia foetida is one of the possible non-edible feedstocks for biodiesel production.
Silitonga, A. S., Chong, W. T., Mahlia, T. M. I., Ong, H. C., Masjuki, H. H., Yusaf, Talal F.   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Optimal Pebbling in Products of Graphs

Australas. J Comb., 2009
28 pages, 1 ...
David S. Herscovici, Benjamin D. Hester, Glenn H. Hurlbert   +2 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Optimizing ethanol production selectivity

Mathematical and Computer Modelling, 2011
Lactococcus lactis metabolizes glucose homofermentatively to lactate. However, after disruption of the gene coding for lactate dehydrogenase, LDH, a key enzyme in NAD^+ regeneration, the glycolytic flux shifts from homolactic to mixed-acid fermentation with the redirection of pyruvate towards production of formate, acetate, ethanol and CO"2.
Raman Lall, Timothy J. Donohue, Simeone Marino, Julie C. Mitchell   +3 more
openaire   +1 more source

Optimal taxation with household production [PDF]

Oxford Economic Papers, 2000
В статье высказывается предположение о том, что при оптимальной налоговой системе должно приветствоваться предоставление тех рыночных услуг, которые являются близкими товарами-заменителями услуг, производимых домохозяйствами. Во-первых, предлагается модификация классического правила Корлетта-Хейга для оптимального налогообложения товаров.
Kleven, Henrik Jacobsen, Richter, Wolfram F., Sørensen, Peter Birch   +2 more
openaire   +4 more sources