Results 61 to 70 of about 19,558,547 (301)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Energy efficiency and productivity improvements analysis in a Brazilian steel plant: simulation model using JaamSim open source software

Discover Energy
The Brazilian steel sector, inserted in a scenario of crisis and competitiveness, is going through a moment when optimization procedures in the production process are well regarded.
Rodrigo de Paula Oliveira, Wilson Trigueiro de Sousa Júnior, Roberta Alves, Alexandre Ferreira de Pinho, Helio Tavares de Sá Neto   +4 more
doaj   +1 more source

Production Optimization and Corporate Productivity in the Nigerian Manufacturing Industry

European Journal of Business and Management, 2020
Production optimization is a required process in any manufacturing sectors; it involve challenges that manifested in form of seasonal variations, size of market, unpredictable circumstances, challenges of dynamic modern technology that provide ...
Gbenga Ologbon Eretan, Babajide D. Adesina   +1 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Mixed Formulation Physics-Informed Neural Network for a Forward and an Inverse Euler–Bernoulli Dynamic Beam Problem

Algorithms
A mixed formulation physics-informed neural network (PINN) for solving a forward and an inverse nonlinear Euler–Bernoulli dynamic beam problem is proposed.
Aliki D. Mouratidou, Emmanouil C. Pyrovolakis, Georgios A. Drosopoulos, Georgios E. Stavroulakis   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Unilateral contact and damage analysis in masonry arches

Vietnam Journal of Mechanics, 2009
In the present work the ultimate failure load and the collapse mechanism of a stone arch bridge are estimated by the usage of (a) a multi - part elastic model with unilateral contact frictional interfaces and (b) a continuous damage model.
M. Campo, G. A. Drosopoulos, G. E. Stavroulakis   +2 more
doaj   +1 more source

Introducing approximate well dynamics into production optimization for operations scheduling

Computers and Chemical Engineering, 2020
Most of the literature on short-term production optimization concerns the computation of optimal system settings for steady-state operations. Such methodologies are applicable when the scales of time are faster than reservoir dynamics, and slower than ...
E. Hulse, T. L. Silva, E. Camponogara, V. R. Rosa, B. Vieira, A. Teixeira   +5 more
semanticscholar   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source