Results 61 to 70 of about 495,373 (264)

Learning-based ship design optimization approach

, 2012
With the development of computer applications in ship design, optimization, as a powerful approach, has been widely used in the design and analysis process.
Philip Sayer, Osman Turan, Turan, Osman, Cui, Hao, Sayer, Philip, Hao Cui   +5 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Press Release: Optimization Systems Associates Inc. a key participant in Raytheon/Texas Instruments Joint Venture MIMIC Program [PDF]

, 1988
Under subcontract to Compact Software Inc., Optimization Systems Associates Inc. is playing a key role in the MIMIC Program's Design Technology in the area of enhanced circuit optimization with tolerances.
Bandler, John W.
core  

Optimization of Bio-fertilizer Production From Watermelon Peels Using Response Surface Methodology.

, 2022
The continuous use of chemical fertilizer affects the environment and soil fertility. Bio-fertilizer helps in safeguarding soil fertility and reduce environmental pollution.
Kyauta , Sunday, Florence Yemi, Olusesi, Amarachi Immaculate, Erugo   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A mixed integer optimization strategy for oil and gas production planning

, 2008
Oil and gas production is the cornerstone of the modern petrochemical industry, and its upstream as well as downstream processing provides many challenges to the process modeling, optimization and control areas.
Pistikopoulos, Efstratios N., Gerogiorgis, Dimitrios   +1 more
core  

CBM Injection/Falling Off Well-Test Parameters' Optimization and Study in the Middle of Qinshui Basin, China [PDF]

, 2018
As one effective mean of obtaining CBM parameters, injection/falling off well-test also has abnormal results. This paper studies process parameters’ optimization such as injecting pressure, injecting volume, shut-in time and reservoir closure pressure ...
LI, Xiaonan, FENG, Qing, LIU, Changqing, HUANG, Zijun, ZENG, Ming   +4 more
core   +1 more source

A Neural Network Constitutive Model and Automatic Stiffness Evaluation for Multiscale Finite Elements

Applied Sciences
A neural network model for a constitutive law in nonlinear structures is proposed in this paper. The artificial neural network (ANN) model is constructed based on a data set of responses from representative volume elements, which was calculated by finite
Aliki D. Mouratidou, Georgios E. Stavroulakis   +1 more
doaj   +1 more source