Results 81 to 90 of about 495,373 (264)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Simulation and Optimization of Integrated Maintenance Strategies for an Aircraft Assembly Process [PDF]
, 2013 In this thesis, the COMAC ARJ21 fuselage’s final assembly process is used as a case study. High production rate (i.e. number of aircraft assembled per year) with reasonable cost is the overall aim in this example.
Li, Jin
core
Conceptual Design of a Novel Biomimetic Underwater Robot
Applications of Modelling and Simulation, 2020 By defining the limits and the design specification, that an underwater robotic vehicle should fulfill in order to be characterized as biomimetic, a shell structure with a modular locomotion mechanism is proposed, using THUNDER piezoelectric, for a novel
George G. Volanis +2 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Integrated optimization model of production planning and scheduling for batch production
, 2004 An integrated optimization model of production plan and scheduling is introduced. Function objective is to minimize sum of total setup cost (initial setup cost and related setup cost), stock cost, production cost and overtime cost.
Shang WL(尚文利), Fan YS(范玉顺)
core
An optimization model for refinery production scheduling
, 2002 In this paper we describe a production planning and scheduling problem in an oil refinery company. The problem concerns the planning and the utilization of a production process consisting of one distillation unit and two hydro-treatment units.
Persson, Jan A., +5 more
core +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Hyper-Heuristic Approach for Improving Marker Efficiency
AUTEX Research Journal, 2018 Marker planning is an optimization arrangement problem, where a set of cutting parts need to be placed on a thin paper without overlapping to create a marker – an exact diagram of cutting parts that will be cut from a single spread.
Domović Daniel +2 more
doaj +1 more source