Results 101 to 110 of about 19,558,547 (301)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Stochastic Simplex Approximate Gradient for Robust Life-Cycle Production Optimization: Applied to Brugge Field

Journal of energy resources technology, 2019
In oil and gas industry, production optimization is a viable technique to maximize the recovery or the net present value (NPV). Robust optimization is one type of production optimization techniques where the geological uncertainty of reservoir is ...
Bai-Lian Chen, Jian-Chun Xu
semanticscholar   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

MOL Report Six - 2014/2015

, 2015
MOL Report Six (2014/2015) compiles 14 papers and presents research on surface mine planning optimization and tailings management, simulation and optimization of mining systems, underground and block-cave production scheduling optimization, and software ...
Pourrahimian, Yashar, Askari-Nasab, Hooman, Ben-Awuah, Eugene   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

An optimization model for energy-efficient machining for sustainable production

, 2019
Sustainable production plays an important role in product lifecycle management by considering the social sustainability. Energy-efficient machining is an efficient approach for sustainable production in current manufacturing sectors.
Wang, H, Tian, X, Zhong, RY, Liu, G, Mu, W, Leng, D   +5 more
core   +1 more source

Hyper-Heuristic Approach for Improving Marker Efficiency

AUTEX Research Journal, 2018
Marker planning is an optimization arrangement problem, where a set of cutting parts need to be placed on a thin paper without overlapping to create a marker – an exact diagram of cutting parts that will be cut from a single spread.
Domović Daniel, Rolich Tomislav, Golub Marin   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

MOL Report Eight - 2016/2017

, 2017
MOL Report Eight (2016/2017) compiles 19 papers and presents research on surface mine planning optimization, simulation and optimization of mining systems, underground and block-cave production scheduling optimization, and related mining systems topics ...
Pourrahimian, Yashar, Askari-Nasab, Hooman, Ben-Awuah, Eugene   +2 more
core   +1 more source

Special Issue: Measurement, Simulation, and Design of Sound in Urban Spaces

Applied Sciences
Sound quality in urban spaces is not only a matter of limit values for noise levels but is also key to human physical and psychological well-being, which makes it a challenge for the latest data analysis techniques [...]
Massimo Garai, Gioia Fusaro, Georgios E. Stavroulakis, Nikolaos M. Papadakis   +3 more
doaj   +1 more source