Results 91 to 100 of about 7,991,419 (293)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Integrated production system optimization using global optimization techniques [PDF]

, 2007
Many optimization problems related to integrated oil and gas production systems are nonconvex and multimodal. Additionally, apart from the innate nonsmoothness of many optimization problems, nonsmooth functions such as minimum and maximum functions may ...
Pinter, J. D., Mason, T. L., Emelle, C., Van Berkel, J., Kampas, F., Bagirov, Adil   +5 more
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Hyper-Heuristic Approach for Improving Marker Efficiency

AUTEX Research Journal, 2018
Marker planning is an optimization arrangement problem, where a set of cutting parts need to be placed on a thin paper without overlapping to create a marker – an exact diagram of cutting parts that will be cut from a single spread.
Domović Daniel, Rolich Tomislav, Golub Marin   +2 more
doaj   +1 more source

Press Release: Optimization Systems Associates Inc. a key participant in Raytheon/Texas Instruments Joint Venture MIMIC Program [PDF]

, 1988
Under subcontract to Compact Software Inc., Optimization Systems Associates Inc. is playing a key role in the MIMIC Program's Design Technology in the area of enhanced circuit optimization with tolerances.
Bandler, John W.
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Short Course on Optimization Technology and Applications in High Frequency and Microwave Circuit Design

, 1994
Course notes and advertisement for a Short Course given at the Department of Electromagnetic Theory and Engineering, Duisburg University, Duisburg, Germany. The course was delivered by John W. Bandler and S.H. Chen on October 4 and 5, 1994.
Bandler, John W., Chen, S.H., Optimization Systems Associates   +2 more
core   +1 more source

Special Issue: Measurement, Simulation, and Design of Sound in Urban Spaces

Applied Sciences
Sound quality in urban spaces is not only a matter of limit values for noise levels but is also key to human physical and psychological well-being, which makes it a challenge for the latest data analysis techniques [...]
Massimo Garai, Gioia Fusaro, Georgios E. Stavroulakis, Nikolaos M. Papadakis   +3 more
doaj   +1 more source