Results 111 to 120 of about 1,894,927 (308)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Production Technology

, 2012
utført i samarbeid med Kongsberg Protech ...
Eide, Halvor Mehlum, Trandem, Sander, Ohm, Ørjan, Svendsen, Alexander, Lia, Knut Anders   +4 more
openaire   +3 more sources

Innovative approaches to integrating gender into conventional maize breeding: lessons from the Seed Production Technology for Africa project. [PDF]

Front Sociol, 2023
Voss RC, Cairns JE, Olsen M, Muteti FN, Magambo Kanyenji G, Hamadziripi E, Ligeyo D, Mashingaidze K, Collinson S, Wanderi S, Woyengo V.   +10 more
europepmc   +1 more source

The design of a bioenergy potential map and a GIS-enabled optimization model for biofuel production in India

, 2019
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2019Cataloged from PDF version of thesis.Includes bibliographical references (pages 71-74).India has a remarkably large inventory of biomass, but the operation of ...
Yan, YanS.M.Massachusetts Institute of Technology.
core  

Computer simulation and analysis of production line with two unreliable full batch machines and a finite buffer [PDF]

, 2006
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006.Includes bibliographical references (leaf 34).This paper investigates computer simulations of deterministic and exponential models of a production line with full ...
Zheng, Ying, S.B. Massachusetts Institute of Technology
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Drug Transport System Based on Phospholipid Nanoparticles: Production Technology and Characteristics. [PDF]

Pharmaceutics, 2022
Tikhonova EG, Sanzhakov MA, Tereshkina YA, Kostryukova LV, Khudoklinova YY, Orlova NA, Bobrova DV, Ipatova OM.   +7 more
europepmc   +1 more source

Beef Reproductive Technology Adoption- Impact of Production Risk and Capitals

Agriculture, Beef, Artificial insemination, Estrus synchronization, Social capital, Production risk, Technology adoption, Farm Management,
Poock, Scott, Rees, Lisa, Patterson, David J., Smith, Michael F., Parcell, Joseph L.   +4 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Commercially Available Enteric Empty Hard Capsules, Production Technology and Application. [PDF]

Pharmaceuticals (Basel), 2022
Franc A, Vetchý D, Fülöpová N.
europepmc   +1 more source