Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On Uneven Ground: How Corporate Governance Prioritizes Short-term Speculative Investments, Impedes Productive Investments, and Jeopardizes Productivity Growth [PDF]
The economic recovery after the Great Recession highlighted a continuous divergence between soaring profits and lagging investment. These trends are related at the corporate level, where corporate managers have stronger incentives to pursue short-term ...
Christian E. Weller, Luke Reidenbach
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Carryover effects of dietary arginine on productive performance and blood biochemistry in Japanese quail (<i>Coturnix japonica</i>). [PDF]
Vet Anim SciGashew M +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Électricité en Afrique et performance productive [PDF]
In the mid 1980's, African electric companies embarked on reform programmes, intending to improve their productive efficiency. Twelve of these networks are studied in this paper. At fïrst, parametric production frontier models are estimated on panel data.
Hofman, Lucile, Plane, Patrick
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Reaction norm models for the evaluation of reproductive and productive performance in Nellore cattle. [PDF]
Trop Anim Health ProdMenezes FL +7 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Productive Failure Writing Queer Transnational South Asian Art Histories
This monograph provides novel methods for writing transnational South Asian art history outside of genealogy.Cover -- Series page -- Title page -- Copyright page -- Contents -- Plates -- Figures -- Preface: Productive failure, cruising and affirmative ...
Patel, Alpesh Kantilal.
core
Dietary pyrroloquinoline quinone supplementation improves productive performance, immunity, and intestinal health in late-phase Jingfen No. 6 laying hens. [PDF]
Poult SciShen X +12 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source