Candidate genes for temporal lobe epilepsy: a replication study [PDF]
, 2018 The objective of this study is to replicate previously published results regarding the involvement of several susceptibility genes in temporal lobe epilepsy (TLE): interleukin 1β (IL-1β), interleukin 1β (IL-1α), interleukin 1RA (IL-1RA), apolipoprotein E
Crespel, Arielle +4 more
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Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs [PDF]
, 2016 Little is knownabout the functions of downstreamregulatory element antagonist modulator (DREAM) inembryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent manner, preventing CREB ...
Aguilera, Yolanda +6 more
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Brain Research BulletinBackground: Microglial pyroptosis-mediated neuroinflammation is a key pathogenic mechanism in Sepsis-Associated Encephalopathy (SAE). However, the role of prodynorphin (PDYN) in SAE and the relationship between PDYN and microglial pyroptosis remain ...
Ao Li +6 more
doaj +1 more source
Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]
, 2012 Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Baseer, N. +5 more
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Frontiers in Aging Neuroscience, 2014 The LOU/C/Jall (LOU) rat strain is considered a model of healthy aging due to its increased longevity, maintenance of stable body weight (BW) throughout life and low incidence of age-related diseases.
Caroline eMenard +10 more
doaj +1 more source
In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons [PDF]
, 2017 Huntington's disease (HD), caused by a CAG repeat expansion in the huntingtin (HTT) gene, is characterized by abnormal protein aggregates and motor and cognitive dysfunction.
Brown, Timothy B. +8 more
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Prodynorphin Processing by Proprotein Convertase 2 [PDF]
Journal of Biological Chemistry, 1998 Robert Day +6 more
openaire +1 more source
اختلال وسواسی- اجباری: آيا در مولتيپل اسکلروزيس شايع است؟ [PDF]
, 2006 هدف: اين بررسی برای ارزيابی فراوانی علايم اختلال وسواسی- اجباری (OCD) در بيماران مبتلا به مولتيپل اسکلروزيس (MS) انجام شده است. روش: تعداد 40 نفر (18 مرد و 22 زن) از بيماران مبتلا به مولتيپل اسکلروزيس با مقياسهای وسواسی اجباری ييل- براون(Y-BOCS) و ...
شعبانی, امير +2 more
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Periphere Mechanismen von Gelenkschmerzen mit speziellem Fokus auf den synovialen Fibroblasten [PDF]
, 2018 Zusammenfassung: Gelenkschmerz ist eine der am häufigsten auftretenden Schmerzformen. Etwa ein Drittel der Bevölkerung hat bereits einmal Gelenkschmerz erfahren.
Sprott, H.
core
Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models [PDF]
, 2016 core +1 more source