Results 91 to 100 of about 3,314 (190)

Suppression of the PI3K/AKT/mTOR signaling pathway by PDYN alleviates sepsis-associated encephalopathy in mice

Brain Research Bulletin
Background: Microglial pyroptosis-mediated neuroinflammation is a key pathogenic mechanism in Sepsis-Associated Encephalopathy (SAE). However, the role of prodynorphin (PDYN) in SAE and the relationship between PDYN and microglial pyroptosis remain ...
Ao Li, Shujuan Qu, Shengfeng Wang, Qiong Guo, Sinian Tan, Mao Peng, Lin Liu   +6 more
doaj   +1 more source

Social Isolation Induces Changes in the Monoaminergic Signalling in the Rat Medial Prefrontal Cortex

Cells
(1) Background: The effects of short-term social isolation during adulthood have not yet been fully established in rats behaviourally, and not at all transcriptomically in the medial prefrontal cortex (mPFC).
Vivien Csikós, Fanni Dóra, Tamás Láng, Luca Darai, Vivien Szendi, Attila Tóth, Melinda Cservenák, Arpád Dobolyi   +7 more
doaj   +1 more source

Nandrolone decanoate administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats

, 2009
The misuse of anabolic androgenic steroids has in several reports been associated with effects resulting in altered behavior and cognition. This study used the Morris water maze task to investigate the effect of high doses of the anabolic androgenic ...
Nyberg, Fred,, Zhou, Qin,, Bazov, Igor,, Magnusson, Kristina,, Clausen, Fredrik,, Hånell, Anders,   +5 more
core   +1 more source

Methamphetamine alters prodynorphin gene expression and dynorphin A levels in rat hypothalamus

, 1999
Chronic administration of morphine or cocaine affects opioid gene expression. To better understand the possible existence of common neuronal pathways shared by different classes of drugs of abuse, we studied the effects of methamphetamine on the gene ...
Sanzio Candeletti, Romualdi Patrizia
core   +1 more source

Alterations in prodynorphin gene expression and dynorphin levels in different brain regions after chronic administration of 14-methoxy-metopon and oxycodone-6-oxime

, 2006
Previous studies showed that opioid drugs-oxycodone-6-oxime and 14-methoxy-5-methyl-dihydromorphinone (14-methoxymetopon)-produced less respiratory depressive effect and slower rate of tolerance and dependence, respectively.
ROMUALDI P., Király K. P., CANDELETTI, SANZIO, DI BENEDETTO M., D'ADDARIO, Claudio, KIRA'LY K. P., RIBA P., LANDUZZI D., CANDELETTI S., D’Addario C., ROMUALDI, PATRIZIA, FURST S., LANDUZZI, DANIELA, DI BENEDETTO, MANUELA   +13 more
core   +1 more source

Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster .1. Regulation of prodynorphin gene expression by nuclear protein kinase C

, 1997
Prodynorphin gene expression was investigated in adult ventricular myocytes isolated from normal (F1B) or cardiomyopathic (BIG 14.6) hamsters, Prodynorphin mRNA levels were higher in cardiomyopathic than in control myocytes and were stimulated by ...
PINTUS, Gianfranco, Fiori MG, Ventura C, Gaspa L., Bennardini F, Pinna G   +5 more
core  

Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster .3. Autocrine stimulation of prodynorphin gene expression by dynorphin B

, 1997
Prodynorphin mRNA and dynorphin B expression have been previously shown to be greatly increased in cardiac myocytes of BIO 14.6 cardiomyopathic hamsters.
PINTUS, Gianfranco, Ventura C
core  

246.The effect of testosterone and season on prodynorphin mRNA expression in the preoptic area hypothalamus of the ram

, 2004
Progesterone stimulates prodynorphin mRNA expression in the hypothalamus of the ewe (1), but whether testosterone regulates dynorphin gene expression in the ram is unknown.
C. J. Scott, I. J. Clarke, A. J. Tilbrook   +2 more
core   +1 more source

Molecular signaling underlying bulleyaconitine A (BAA)-induced microglial expression of prodynorphin

, 2017
Bulleyaconitine (BAA) has been shown to possess antinociceptive activities by stimulation of dynorphin A release from spinal microglia. This study investigated its underlying signal transduction mechanisms.
Yi-Rui Wang, Yong-Xiang Wang, Hai-Yun Wu, Xin-Yan Li, Teng-Fei Li   +4 more
core   +1 more source

Ethanol and acetaldehyde exposure induces specific epigenetic modifications in the prodynorphin gene promoter in a human neuroblastoma cell line.

, 2010
Ethanol alters neural activity through interaction with multiple neurotransmitters and neuromodulators. The endogenous opioid system seems to play a key role, since the opioid receptor antagonist naltrexone (ReVia®) attenuates craving for alcohol.
Johansson S, Ögren SO, CANDELETTI, SANZIO, Ekström T.J., D'Addario C, ROMUALDI, PATRIZIA, Terenius L, Sofia Johansson, Sanzio Candeletti, Claudio D'Addario, D'Addario, C, Candeletti, S, Terenius, L,, Ogren, SO, Patrizia Romualdi, Tomas J. Ekström, Johansson, S, Ekstrom, TJ, Romualdi, P, Lars Terenius, Sven Ove Ögren   +20 more
core   +1 more source