Results 91 to 100 of about 3,057 (188)

Alterations in prodynorphin gene expression and dynorphin levels in different brain regions after chronic administration of 14-methoxy-metopon and oxycodone-6-oxime

, 2006
Previous studies showed that opioid drugs-oxycodone-6-oxime and 14-methoxy-5-methyl-dihydromorphinone (14-methoxymetopon)-produced less respiratory depressive effect and slower rate of tolerance and dependence, respectively.
ROMUALDI P., Király K. P., CANDELETTI, SANZIO, DI BENEDETTO M., D'ADDARIO, Claudio, KIRA'LY K. P., RIBA P., LANDUZZI D., CANDELETTI S., D’Addario C., ROMUALDI, PATRIZIA, FURST S., LANDUZZI, DANIELA, DI BENEDETTO, MANUELA   +13 more
core   +1 more source

Social Isolation Induces Changes in the Monoaminergic Signalling in the Rat Medial Prefrontal Cortex

Cells
(1) Background: The effects of short-term social isolation during adulthood have not yet been fully established in rats behaviourally, and not at all transcriptomically in the medial prefrontal cortex (mPFC).
Vivien Csikós, Fanni Dóra, Tamás Láng, Luca Darai, Vivien Szendi, Attila Tóth, Melinda Cservenák, Arpád Dobolyi   +7 more
doaj   +1 more source

Early Changes in Prodynorphin mRNA and ir‐Dynorphin A Levels after Kindled Seizures in the Rat

, 1995
Prodynorphin mRNA and immunoreactive dynorphin A (ir‐dynorphin A) levels were measured in different brain areas at various time points after amygdala kindled seizures.
ROMUALDI P., BIANCHI, Clementina, FERRI S., SIMONATO, Michele, DONATINI A., BREGOLA, Gianni, BEANI, Lorenzo   +6 more
core   +1 more source

Ethanol and acetaldehyde exposure induces specific epigenetic modifications in the prodynorphin gene promoter in a human neuroblastoma cell line.

, 2011
Ethanol alters neural activity through interaction with multiple neurotransmitters and neuromodulators. The endogenous opioid system seems to play a key role, since the opioid receptor antagonist naltrexone (ReVia®) attenuates craving for alcohol.
Johansson S, Ögren SO, CANDELETTI, SANZIO, Romualdi P, Candeletti S, Ekström T.J., D'Addario C, ROMUALDI, PATRIZIA, Terenius L, D'ADDARIO, Claudio   +9 more
core   +2 more sources

Effects of prolonged treatment with the opiate tramadol on prodynorphin gene expression in rat CNS.

, 2006
A low abuse liability is reported for tramadol, an analgesic drug centrally acting through either opioid or nonopioid mechanisms. In this paper, we evaluated the effects of the repeated administration (7 d) of different doses of tramadol (10, 20, and ...
CANNARSA, ROSALIA, LOPETUSO, GIUSEPPE, CANDELETTI, SANZIO, CAVINA, CHIARA, ROMUALDI, PATRIZIA   +4 more
core   +1 more source

The effect of testosterone and season on prodynorphin messenger RNA expression in the preoptic area-hypothalamus of the ram

, 2008
Testosterone and season influence mRNA expression for the opioid, enkephalin, in the preoptic area and hypothalamus of rams. Dynorphin is another opioid which has been shown to play a role in the control of reproductive function in females. We now report
Clarke, Iain J., Tilbrook, Alan J., Scott, Christopher J.   +2 more
core   +1 more source

Molecular pathways of pain: Fos/Jun-mediated activation of a noncanonical AP-1 site in the prodynorphin gene

, 2013
Noxious stimulation provokes the activation of genes that are thought to play a crucial role in the phenomena of stress and pain. Among these is the prodynorphin gene.
Sassone-Corsi, Paolo, Naranjo, José Ramón, Mellström, Britt, Achaval, M.   +3 more
core   +1 more source

Molecular mechanisms of pain: Serotonin(1A) receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons

, 2013
By using spinal cord neurons cultured in chemically defined medium, a double labeling procedure, and blockage with antisense oligonucleotides, we show that induction of c-fos and the subsequent transactivation of the prodynorphin gene are coupled events,
Lucas, José Javier, Naranjo, José Ramón, Mellström, Britt, Colado, M. I.   +3 more
core   +1 more source

Activation of endogenous opioid gene expression in human keratinocytes and fibroblasts by pulsed radiofrequency energy fields

Journal of Pain Research, 2012
John Moffett,1 Linley M Fray,1 Nicole J Kubat21Life Science Department, 2Independent Consultant, Regenesis Biomedical Inc, Scottsdale, AZ, USABackground: Pulsed radiofrequency energy (PRFE) fields are being used increasingly for the treatment of pain ...
Moffett J, Fray LM, Kubat NJ
doaj  

In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells. [PDF]

Reprod Biol Endocrinol
Miyake N, Suga H, Osuka S, Seki T, Sonehara R, Muraoka A, Nakamura T, Bayasula, Miwata T, Soen M, Sakakibara M, Go S, Hasegawa S, Inoue N, Uenoyama Y, Tsukamura H, Arima H, Kajiyama H.   +17 more
europepmc   +1 more source