Results 81 to 90 of about 3,314 (190)

Chronic intracerebroventricular cocaine differentially affects prodynorphin gene expression in rat hypothalamus and caudate-putamen

, 1996
We investigated the effects of sustained administration of cocaine on the regulation of prodynorphin gene expression in rat brain. Intracerebroventricular (i.c.v.) infusion of cocaine hydrochloride (30 μg/day) for 7 days, by means of osmotic minipumps ...
Romualdi, Patrizia, Donatini, Alessandra, Ferri, Sergio, Cox, Brian M, Izenwasser, Sari, Ferri S, Romualdi P   +6 more
core   +2 more sources

Prodynorphin mRNA is synthesized in adult cultured rat ventricular cardiomyocytes

, 1993
In the myocardial cell, stimulation of the K opioid receptor is involved in the modulation of cytosolic calcium and pH homeostasis, as well as in the regulation of myofilament responsiveness to calcium.
Carboni L., Caldarera C. M., Ventura C., Canossa M., Vaona I., Spampinato S., Guarnieri C.   +6 more
core   +1 more source

Age-Related Changes in Brain Prodynorphin Gene Expression in the Rat

, 2004
Dynorphin has a well-established role in feeding and gustation. Alterations in taste perception and feeding behavior are common with age. We hypothesized that proDynorphin gene expression in brain areas involved in taste and feeding declines with age ...
Kotz, Catherine M., Levine, Allen S., Weldon, Derik, Billington, Charles J.   +3 more
core   +1 more source

A genetic polymorphism of the endogenous opioid dynorphin modulates monetary reward anticipation in the corticostriatal loop.

PLoS ONE, 2014
The dynorphin/κ-opioid receptor (KOP-R) system has been shown to play a role in different types of behavior regulation, including reward-related behavior and drug craving.
Mikhail Votinov, Mikhail Votinov, Juergen Pripfl, Christian Windischberger, Klaudius Kalcher, Alexander Zimprich, Fritz Zimprich, Ewald Moser, Claus Lamm, Uta Sailer   +9 more
doaj   +1 more source

Association between heroin dependence and prodynorphin gene polymorphisms

Brain Research Bulletin, 2011
Dynorphin peptides and k-opioid receptor are important in the rewarding effects of drugs of abuse such as heroin. This study examined potential association between heroin dependence and four single nucleotide polymorphisms (SNPs) of prodynorphin (PDYN) gene (rs35286281 in promoter region and rs1022563, rs2235749, rs910080 in 3'UTR).
S G, Wei, Y S, Zhu, J H, Lai, H X, Xue, Z Q, Chai, S B, Li   +5 more
openaire   +2 more sources

Prodynorphin-expressing neurons in the ventromedial hypothalamus respond to the predatory odor and modulate defensive behaviors

Brain Research Bulletin
The ventromedial hypothalamus (VMH) regulates stress responses and defensive behaviors. However, the neural mechanisms underlying its involvement in threat perception remain incompletely understood.
Ting He
doaj   +1 more source

Radiofrequency Energy Loop Primes Cardiac, Neuronal, and Skeletal Muscle Differentiation in Mouse Embryonic Stem Cells: A New Tool for Improving Tissue Regeneration

Cell Transplantation, 2012
Radiofrequency (RF) waves from Wi-Fi (wireless fidelity) technologies have become ubiquitous, with Internet access spreading into homes, and public areas. The human body harbors multipotent stem cells with various grading of potentiality.
Margherita Maioli, Salvatore Rinaldi, Sara Santaniello, Alessandro Castagna, Gianfranco Pigliaru, Sara Gualini, Vania Fontani, Carlo Ventura   +7 more
doaj   +1 more source

Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish.

PLoS ONE, 2011
A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to ...
Beng-Siang Khor, Mohd Fadzly Amar Jamil, Mohamad Ilham Adenan, Alexander Chong Shu-Chien   +3 more
doaj   +1 more source

Radio Electric Conveyed Fields Directly Reprogram Human Dermal Skin Fibroblasts toward Cardiac, Neuronal, and Skeletal Muscle-Like Lineages

Cell Transplantation, 2013
Somatic cells can be directly reprogrammed to alternative differentiated fates without first becoming stem/progenitor cells. Nevertheless, the initial need for viral-mediated gene delivery renders this strategy unsafe in humans. Here, we provide evidence
Margherita Maioli, Salvatore Rinaldi, Sara Santaniello, Alessandro Castagna, Gianfranco Pigliaru, Sara Gualini, Claudia Cavallini, Vania Fontani, Carlo Ventura   +8 more
doaj   +1 more source

TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons

Molecular Metabolism, 2015
Objective: Leptin acts via its receptor (LepRb) on multiple subpopulations of LepRb neurons in the brain, each of which controls specific aspects of energy balance.
Margaret B. Allison, Christa M. Patterson, Michael J. Krashes, Bradford B. Lowell, Martin G. Myers, Jr., David P. Olson   +5 more
doaj   +1 more source