Results 81 to 90 of about 3,057 (188)

Prodynorphin-expressing neurons in the ventromedial hypothalamus respond to the predatory odor and modulate defensive behaviors

Brain Research Bulletin
The ventromedial hypothalamus (VMH) regulates stress responses and defensive behaviors. However, the neural mechanisms underlying its involvement in threat perception remain incompletely understood.
Ting He
doaj   +1 more source

Radio Electric Conveyed Fields Directly Reprogram Human Dermal Skin Fibroblasts toward Cardiac, Neuronal, and Skeletal Muscle-Like Lineages

Cell Transplantation, 2013
Somatic cells can be directly reprogrammed to alternative differentiated fates without first becoming stem/progenitor cells. Nevertheless, the initial need for viral-mediated gene delivery renders this strategy unsafe in humans. Here, we provide evidence
Margherita Maioli, Salvatore Rinaldi, Sara Santaniello, Alessandro Castagna, Gianfranco Pigliaru, Sara Gualini, Claudia Cavallini, Vania Fontani, Carlo Ventura   +8 more
doaj   +1 more source

Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish.

PLoS ONE, 2011
A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to ...
Beng-Siang Khor, Mohd Fadzly Amar Jamil, Mohamad Ilham Adenan, Alexander Chong Shu-Chien   +3 more
doaj   +1 more source

Molecular signaling underlying bulleyaconitine A (BAA)-induced microglial expression of prodynorphin

, 2017
Bulleyaconitine (BAA) has been shown to possess antinociceptive activities by stimulation of dynorphin A release from spinal microglia. This study investigated its underlying signal transduction mechanisms.
Yi-Rui Wang, Yong-Xiang Wang, Hai-Yun Wu, Xin-Yan Li, Teng-Fei Li   +4 more
core   +1 more source

Kindled seizure-induced c-fos and prodynorphin mRNA expressions are unrelated in the rat brain

, 1996
Levels of mRNA for c-fos and prodynorphin were studied by in situ hybridization in adjacent coronal sections taken from kindled rats 30-60 min after the last seizure.
BIANCHI, Clementina, ROMUALDI P., SIMONATO, Michele, FERRI S., DONATINI A., BREGOLA, Gianni, BEANI, Lorenzo   +6 more
core   +2 more sources

Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABAA receptor subunits gene expression in the amygdala [PDF]

, 2011
This study evaluated the role of prodynorphin gene in the regulation of anxiety and associated molecular mechanisms. Emotional responses were assessed using the light–dark test, elevated plus maze and social interaction tests in prodynorphin knockout ...
Irigüen, Leyre, Pérez Rial, Sandra, Manzanares, Jorge, Femenía Cantó, Teresa   +3 more
core   +1 more source

Radiofrequency Energy Loop Primes Cardiac, Neuronal, and Skeletal Muscle Differentiation in Mouse Embryonic Stem Cells: A New Tool for Improving Tissue Regeneration

Cell Transplantation, 2012
Radiofrequency (RF) waves from Wi-Fi (wireless fidelity) technologies have become ubiquitous, with Internet access spreading into homes, and public areas. The human body harbors multipotent stem cells with various grading of potentiality.
Margherita Maioli, Salvatore Rinaldi, Sara Santaniello, Alessandro Castagna, Gianfranco Pigliaru, Sara Gualini, Vania Fontani, Carlo Ventura   +7 more
doaj   +1 more source

TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons

Molecular Metabolism, 2015
Objective: Leptin acts via its receptor (LepRb) on multiple subpopulations of LepRb neurons in the brain, each of which controls specific aspects of energy balance.
Margaret B. Allison, Christa M. Patterson, Michael J. Krashes, Bradford B. Lowell, Martin G. Myers, Jr., David P. Olson   +5 more
doaj   +1 more source

Methamphetamine alters prodynorphin gene expression and dynorphin A levels in rat hypothalamus

, 1999
Chronic administration of morphine or cocaine affects opioid gene expression. To better understand the possible existence of common neuronal pathways shared by different classes of drugs of abuse, we studied the effects of methamphetamine on the gene ...
Sanzio Candeletti, Romualdi Patrizia
core   +1 more source

Suppression of the PI3K/AKT/mTOR signaling pathway by PDYN alleviates sepsis-associated encephalopathy in mice

Brain Research Bulletin
Background: Microglial pyroptosis-mediated neuroinflammation is a key pathogenic mechanism in Sepsis-Associated Encephalopathy (SAE). However, the role of prodynorphin (PDYN) in SAE and the relationship between PDYN and microglial pyroptosis remain ...
Ao Li, Shujuan Qu, Shengfeng Wang, Qiong Guo, Sinian Tan, Mao Peng, Lin Liu   +6 more
doaj   +1 more source