Cellular Profiles of Prodynorphin and Preproenkephalin mRNA-Expressing Neurons in the Anterior Olfactory Tubercle of Mice [PDF]
Frontiers in Neural Circuits, 2022 The olfactory tubercle (OT) is a striatal region that receives olfactory inputs. mRNAs of prodynorphin (Pdyn) and preproenkephalin (Penk), precursors of dynorphins and enkephalins, respectively, are strongly expressed in the striatum. Both produce opioid
Ayako Maegawa +9 more
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Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life [PDF]
Frontiers in Neural CircuitsOlfactory dysfunctions decrease daily quality of life (QOL) in part by reducing the pleasure of eating. Olfaction plays an essential role in flavor sensation and palatability.
Koshi Murata +9 more
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Transcriptional Regulatory Role of NELL2 in Preproenkephalin Gene Expression. [PDF]
Mol Cells, 2022 Preproenkephalin (PPE) is a precursor molecule for multiple endogenous opioid peptides Leu-enkephalin (ENK) and Met-ENK, which are involved in a wide variety of modulatory functions in the nervous system. Despite the functional importance of ENK in the brain, the effect of brain-derived factor(s) on PPE expression is unknown.
Ha CM +10 more
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The Involvement of Endogenous Enkephalins in Glucose Homeostasis [PDF]
Biomedicines, 2023 Obesity has nearly tripled since 1975 and is predicted to continue to escalate. The surge in obesity is expected to increase the risk of diabetes type 2, hypertension, coronary artery disease, and stroke.
Vanessa Escolero +4 more
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Frontiers in Genetics, 2022 Short tandem repeats (STRs) and variable number of tandem repeats (VNTRs) that have been identified at approximately 0.7 and 0.5 million loci in the human genome, respectively, are highly multi-allelic variations rather than single-nucleotide ...
Shinya Kasai +7 more
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The structure and expression of the preproenkephalin gene [PDF]
Nucleic Acids Research, 1982 Enkephalins are pentapeptides with opioid activity which are found in a wide variety of tissues. Studies of enkephalin-containing peptides from the adrenal gland have established that the mature pentapeptides are derived by proteolytic processing of a precursor protein.
Legon, Steve +5 more
openaire +3 more sources
Acetaminophen improves tardive akathisia induced by dopamine D2 receptor antagonists
Journal of Pharmacological Sciences, 2023 Tardive akathisia is a movement disorder characterized by internal restlessness with an uncontrollable urge to move, leading to repetitive movements. It is a common side effect of long-term treatment with dopamine D2 receptor antagonists.
Koki Nagaoka +3 more
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Maternally administered sustained-release naltrexone in rats affects offspring neurochemistry and behaviour in adulthood. [PDF]
PLoS ONE, 2012 Naltrexone is not recommended during pregnancy. However, sustained-release naltrexone implant use in humans has resulted in cases of inadvertent foetal exposure.
Waleed O Farid +5 more
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Differential Changes in Striatal Projection Neurons in R6/2 Transgenic Mice for Huntington's Disease
Neurobiology of Disease, 2002 In early adult-onset Huntington's disease (HD), enkephalinergic striatopallidal projection neurons show preferential loss, reduced preproenkephalin (PPE) expression in surviving striatopallidal neurons, and loss of fibers in their projection target area.
Z. Sun +4 more
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Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons. [PDF]
PLoS ONE, 2009 The widespread distribution of the tumor suppressor PTEN in the nervous system suggests a role in a broad range of brain functions. PTEN negatively regulates the signaling pathways initiated by protein kinase B (Akt) thereby regulating signals for growth,
Oscar Diaz-Ruiz +7 more
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