Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease [PDF]
Annals of Clinical and Translational NeurologyObjective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers ...
Daniel Chelsky +8 more
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Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions [PDF]
Frontiers in Physiology, 2023 The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec +1 more
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Sub-chronic stress exerts partially distinct behavioral and epigenetic effects in male and female mice [PDF]
Frontiers in Behavioral NeuroscienceIntroductionStress-related disorders, such as major depression, anxiety disorders, and post-traumatic stress disorder, lead to considerable disease burden and are notoriously difficult to treat.
Matthew J. Domanico +6 more
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Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions [PDF]
Molecular MetabolismObjective: Dynorphin, an endogenous opioid peptide predominantly expressed in the central nervous system and involved in stress response, pain, and addiction, has intrigued researchers due to its expression in pancreatic β-cells.
Miranda Movahed +2 more
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Estrogen promotes gonadotropin-releasing hormone expression by regulating tachykinin 3 and prodynorphin systems in chicken [PDF]
Poultry Science: The “KNDy neurons” located in the hypothalamic arcuate nucleus (ARC) of mammals are known to co-express kisspeptin, neurokinin B (NKB), and dynorphin (DYN), and have been identified as key mediators of the feedback regulation of steroid hormones on ...
Xing Wu +18 more
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Functional Suppression of CLOCK Activity in Ventromedial Hypothalamic Prodynorphin Neurons Alters Locomotor Activity and Rapid Eye Movement Sleep [PDF]
Neurology InternationalBackground/Objectives: The circadian regulator, circadian locomotor output cycles kaput (CLOCK), is well-established in maintaining sleep–wake rhythms, yet its cell-type-specific functions in sleep regulation remain largely unexplored. While ventromedial
Ting He, Xu Wang
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Neurexin 3 Regulates Synaptic Connections Between Central Amygdala Neurons and Excitable Cells of the Lateral Parabrachial Nucleus in Rats with Varicella Zoster Induced Orofacial Pain [PDF]
Journal of Pain ResearchPhillip R Kramer,1 Rebecca S Hornung,1 Mikhail Umorin,1 M Douglas Benson,1 Paul R Kinchington2 1Department of Biomedical Sciences, Texas A&M University School of Dentistry, Dallas, TX, USA; 2Department of Ophthalmology and of Molecular Microbiology and ...
Kramer PR +4 more
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Molecules, 2021 Neuropeptides serve as neurohormones and local paracrine regulators that control neural networks regulating behavior, endocrine system and sensorimotor functions. Their expression is characterized by exceptionally restricted profiles.
Olga Nosova +4 more
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Frontiers in Genetics, 2022 Short tandem repeats (STRs) and variable number of tandem repeats (VNTRs) that have been identified at approximately 0.7 and 0.5 million loci in the human genome, respectively, are highly multi-allelic variations rather than single-nucleotide ...
Shinya Kasai +7 more
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Frontiers in Neural Circuits, 2022 The olfactory tubercle (OT) is a striatal region that receives olfactory inputs. mRNAs of prodynorphin (Pdyn) and preproenkephalin (Penk), precursors of dynorphins and enkephalins, respectively, are strongly expressed in the striatum. Both produce opioid
Ayako Maegawa +9 more
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