Results 41 to 50 of about 3,057 (188)

Inflammatory-linked changes in CpG island methylation of three opioid peptide genes in a rat model for pain. [PDF]

PLoS ONE, 2018
Expression of the opioid peptide genes proopiomelanocortin (Pomc), proenkephalin (Penk), and prodynorphin (Pdyn), in immune cells plays a key role in endogenous pain control.
Charlotte Louise Justine Jacobi, Christoph Stein   +1 more
doaj   +1 more source

Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis

BMC Psychiatry, 2019
Background Prodynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility ...
Chang-wang Wang, Min Ma, Wei-guang Lu, Ru-qin Luo   +3 more
doaj   +1 more source

Behavioural characterization of prodynorphin knockout mice [PDF]

BMC Pharmacology, 2008
Dynorphin, with a high selectivity for kappa opioid receptors, is a member of the opioid peptide family. Application of opioid agonists and antagonists revealed crucial effects of the opioid system in numerous physiological functions. However, data obtained are often contradictive, reflecting the complex situation of the cross-activation of 3 receptors
Schunk, Eduard, Rosskothen, Iris, Wittmann, Walter, Gaburro, Stefano, Singewald, Nicolas, Herzog, Herbert, Schwarzer, Christoph   +6 more
openaire   +1 more source

Antidyskinetic Treatment with MTEP Affects Multiple Molecular Pathways in the Parkinsonian Striatum

Parkinson's Disease, 2017
Parkinson’s disease is characterized by dopaminergic neuron loss and dopamine (DA) depletion in the striatum. Standard treatment is still focused on the restoration of dopamine with exogenous L-Dopa, which however causes L-Dopa-induced dyskinesia (LID ...
Jing-ya Lin, Zhen-guo Liu, Cheng-long Xie, Lu Song, Ai-juan Yan   +4 more
doaj   +1 more source

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
doaj   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, EarlyView.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Input–output connections of LJA5 prodynorphin neurons

Journal of Comparative Neurology, 2020
Abstract Sensory information is transmitted from peripheral nerves, through the spinal cord, and up to the brain. Sensory information may be modulated by projections from the brain to the spinal cord, but the neural substrates for top‐down sensory control are incompletely understood.
Lindsay J. Agostinelli, Madison R. Mix, Marco M. Hefti, Thomas E. Scammell, Alexander G. Bassuk   +4 more
openaire   +2 more sources

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life

Frontiers in Neural Circuits
Olfactory dysfunctions decrease daily quality of life (QOL) in part by reducing the pleasure of eating. Olfaction plays an essential role in flavor sensation and palatability.
Koshi Murata, Koshi Murata, Ayako Maegawa, Ayako Maegawa, Ayako Maegawa, Yoshimasa Imoto, Yoshimasa Imoto, Shigeharu Fujieda, Yugo Fukazawa, Yugo Fukazawa   +9 more
doaj   +1 more source

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

Journal of Neuroinflammation, 2012
Background The striato-nigral projecting pathway contains the highest concentrations of dynorphin in the brain. The functional role of this opioid peptide in the regulation of mesencephalic dopaminergic (DAergic) neurons is not clear.
Wang Qingshan, Shin Eun-Joo, Nguyen Xuan-Khanh, Li Quan, Bach Jae-Hyung, Bing Guoying, Kim Won-Ki, Kim Hyoung-Chun, Hong Jau-Shyong   +8 more
doaj   +1 more source