Results 41 to 50 of about 3,314 (190)

Behavioural characterization of prodynorphin knockout mice [PDF]

BMC Pharmacology, 2008
Dynorphin, with a high selectivity for kappa opioid receptors, is a member of the opioid peptide family. Application of opioid agonists and antagonists revealed crucial effects of the opioid system in numerous physiological functions. However, data obtained are often contradictive, reflecting the complex situation of the cross-activation of 3 receptors
Schunk, Eduard, Rosskothen, Iris, Wittmann, Walter, Gaburro, Stefano, Singewald, Nicolas, Herzog, Herbert, Schwarzer, Christoph   +6 more
openaire   +1 more source

Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis

BMC Psychiatry, 2019
Background Prodynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility ...
Chang-wang Wang, Min Ma, Wei-guang Lu, Ru-qin Luo   +3 more
doaj   +1 more source

The Role of Kappa‐Opioid Receptor/Dynorphin System in Modulating Neural‐Circuits of Depression and Anxiety—A Review [PDF]

J Cell Mol Med
ABSTRACT Major depression and anxiety disorders are psychiatric disorders that involve a great number of people. There is a growing need for new and better pharmacological treatments for these diseases. Kappa‐opioid receptor (KOR) antagonists seem to be a promising new pathway for the development of new antidepressants and anxiolytics, but a great ...
Ciotei C, Păunescu H, Lungu C, Marica A, Tănase M, Marin R, Costescu M, Fulga I, Coman O.   +8 more
europepmc   +2 more sources

Input–output connections of LJA5 prodynorphin neurons

Journal of Comparative Neurology, 2020
Abstract Sensory information is transmitted from peripheral nerves, through the spinal cord, and up to the brain. Sensory information may be modulated by projections from the brain to the spinal cord, but the neural substrates for top‐down sensory control are incompletely understood.
Lindsay J. Agostinelli, Madison R. Mix, Marco M. Hefti, Thomas E. Scammell, Alexander G. Bassuk   +4 more
openaire   +2 more sources

Antidyskinetic Treatment with MTEP Affects Multiple Molecular Pathways in the Parkinsonian Striatum

Parkinson's Disease, 2017
Parkinson’s disease is characterized by dopaminergic neuron loss and dopamine (DA) depletion in the striatum. Standard treatment is still focused on the restoration of dopamine with exogenous L-Dopa, which however causes L-Dopa-induced dyskinesia (LID ...
Jing-ya Lin, Zhen-guo Liu, Cheng-long Xie, Lu Song, Ai-juan Yan   +4 more
doaj   +1 more source

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
doaj   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, Volume 183, Issue 23, Page 6865-6882, December 2026.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Early changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures in the rat

, 1995
Prodynorphin mRNA and immunoreactive dynorphin A (ir‐dynorphin A) levels were measured in different brain areas at various time points after amygdala kindled seizures.
ROMUALDI P., BIANCHI, Clementina, FERRI S., SIMONATO, Michele, DONATINI A., BREGOLA, Gianni, BEANI, Lorenzo, Bianchi, C, Simonato, M, Bregola, G, Donatini, A, Ferri, S, Romualdi, P, Beani, L   +13 more
core   +2 more sources

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life

Frontiers in Neural Circuits
Olfactory dysfunctions decrease daily quality of life (QOL) in part by reducing the pleasure of eating. Olfaction plays an essential role in flavor sensation and palatability.
Koshi Murata, Koshi Murata, Ayako Maegawa, Ayako Maegawa, Ayako Maegawa, Yoshimasa Imoto, Yoshimasa Imoto, Shigeharu Fujieda, Yugo Fukazawa, Yugo Fukazawa   +9 more
doaj   +1 more source