Results 51 to 60 of about 3,057 (188)

Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
The nucleus of the solitary tract (NTS) integrates visceral inputs to coordinate appetite and digestion, breathing, and cardiorespiratory reflexes. Using cell‐type‐specific tracing, we show that excitatory Lmx1b neurons project broadly to brainstem and forebrain targets, whereas inhibitory output remains largely brainstem‐restricted. Catecholaminergic (
Silvia Gasparini, Haidong Zhu, Ana Sofia Peraza Munuzuri, Mya L. Leuang, Frederico S. Fazan, Joel C. Geerling   +5 more
wiley   +1 more source

Conformation effects of CpG methylation on single-stranded DNA oligonucleotides: analysis of the opioid peptide dynorphin-coding sequences. [PDF]

PLoS ONE, 2012
Single-stranded DNA (ssDNA) is characterized by high conformational flexibility that allows these molecules to adopt a variety of conformations. Here we used native polyacrylamide gel electrophoresis (PAGE), circular dichroism (CD) spectroscopy and ...
Malik Mumtaz Taqi, Sebastian K T S Wärmländer, Olga Yamskova, Fatemeh Madani, Igor Bazov, Jinghui Luo, Roman Zubarev, Dineke Verbeek, Astrid Gräslund, Georgy Bakalkin   +9 more
doaj   +1 more source

Alcohol dependence, disinhibited behavior and variation in the prodynorphin gene [PDF]

Biological Psychology, 2011
The results of the current analyses present preliminary evidence of an association between putatively functional variation in the prodynorphin (PDYN) gene and a dimensional measure of disinhibited behavior. A 68bp sequence in the core promoter region of the PDYN gene was genotyped in a community sample of 1021 adults aged 30-54.
Janine D, Flory, Carolyn L, Pytte, Yasmin, Hurd, Robert E, Ferrell, Stephen B, Manuck   +4 more
openaire   +2 more sources

Inhibitory role of inducible cAMP early repressor (ICER) in methamphetamine-induced locomotor sensitization. [PDF]

PLoS ONE, 2011
BACKGROUND: The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is highly expressed in the central nervous system and functions as a repressor of cAMP response element-binding protein (CREB) transcription.
Wenhua Han, Yukio Takamatsu, Hideko Yamamoto, Shinya Kasai, Shogo Endo, Tomoaki Shirao, Nobuhiko Kojima, Kazutaka Ikeda   +7 more
doaj   +1 more source

Supraspinal Circuit Mechanisms Underlying Itch Processing

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Peripheral pruriceptive signals ascend from the spinal cord to the brainstem, thalamus, and cortex to encode the sensory features of itch. Parallel projections to limbic and basal ganglia circuits mediate affective and motivational components, including aversion and scratching urge.
Yuncheng Luo, Hao‐Di Tang, Ping Liao, Ruotian Jiang   +3 more
wiley   +1 more source

Ameliorative Effect of Taurine on Nandrolone Decanoate Induced Toxicity on Brain, Heart and Testis in Adult Male Albino Rats [PDF]

Zagazig Journal of Forensic Medicine and Toxicology
Background: The most prescribed anabolic steroid in gym practice is nandrolone decanoate (ND). It is implicated in sport doping, and criminal circles where personal aggressiveness was evident.
Elham Megahed, Dena Abdel Moawed, Sara Abdel Aal, Samar Mohamed, Aliaa Talaat, Ghadeer Abdelaal   +5 more
doaj   +1 more source

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +1 more source

Role of serotonin on cocaine mediated effects on prodynorphin gene expression in the rat brain

, 2004
The effect of the selective serotonin uptake inhibitor fluoxetine was examined on prodynorphin gene expression. Fluoxetine or vehicle was infused continuously for 7 d via osmotic minipumps into male rats.
IZENWASSER S, ROMUALDI P., DI BENEDETTO M, COLLINS SL, CANDELETTI S, D'ADDARIO, Claudio   +5 more
core   +3 more sources

Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. [PDF]

PLoS ONE, 2014
Dynorphins, endogenous opioid peptides that arise from the precursor protein prodynorphin (Pdyn), are hypothesized to be involved in the regulation of mood states and the neuroplasticity associated with addiction.
Ami Cohen, Timothy W Whitfield, Max Kreifeldt, Pascale Koebel, Brigitte L Kieffer, Candice Contet, Olivier George, George F Koob   +7 more
doaj   +1 more source

Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Biomedicines, 2021
Mutations in the prodynorphin gene (PDYN) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the PDYN region coding for the dynorphin A (DynA) neuropeptide and lead ...
Andreas Lieb, Germana Thaler, Barbara Fogli, Olga Trovato, Mitja Amon Posch, Teresa Kaserer, Luca Zangrandi   +6 more
doaj   +1 more source