Results 51 to 60 of about 3,314 (190)

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

Journal of Neuroinflammation, 2012
Background The striato-nigral projecting pathway contains the highest concentrations of dynorphin in the brain. The functional role of this opioid peptide in the regulation of mesencephalic dopaminergic (DAergic) neurons is not clear.
Wang Qingshan, Shin Eun-Joo, Nguyen Xuan-Khanh, Li Quan, Bach Jae-Hyung, Bing Guoying, Kim Won-Ki, Kim Hyoung-Chun, Hong Jau-Shyong   +8 more
doaj   +1 more source

Conformation effects of CpG methylation on single-stranded DNA oligonucleotides: analysis of the opioid peptide dynorphin-coding sequences. [PDF]

PLoS ONE, 2012
Single-stranded DNA (ssDNA) is characterized by high conformational flexibility that allows these molecules to adopt a variety of conformations. Here we used native polyacrylamide gel electrophoresis (PAGE), circular dichroism (CD) spectroscopy and ...
Malik Mumtaz Taqi, Sebastian K T S Wärmländer, Olga Yamskova, Fatemeh Madani, Igor Bazov, Jinghui Luo, Roman Zubarev, Dineke Verbeek, Astrid Gräslund, Georgy Bakalkin   +9 more
doaj   +1 more source

Acute ayahuasca administration attenuates binge‐like eating and anxiety‐related behaviors in mice subjected to intermittent fasting

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Human binge eating disorder is characterized by recurrent episodes of excessive food consumption accompanied by loss of control and is strongly associated with alterations in reward processing and emotional regulation. Ayahuasca, a psychoactive botanical preparation traditionally used in Amazonian medicine, has been shown to modulate ...
Cristian Ferreira Corona, Felipe Alves Alencar Lima, Jessica Sabrina Canedo da Silva Sumensse, Kevin Donansan Carvalho, Pedro Henrique Grignet, Heloisa Deola Confortim, Maria Claudia Gross, Fabiana Aidar Firmino, Fernanda Ferreira Evangelista, Francisney Pinto Nascimento, Jean Franciesco Vettorazzi   +10 more
wiley   +1 more source

Inhibitory role of inducible cAMP early repressor (ICER) in methamphetamine-induced locomotor sensitization. [PDF]

PLoS ONE, 2011
BACKGROUND: The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is highly expressed in the central nervous system and functions as a repressor of cAMP response element-binding protein (CREB) transcription.
Wenhua Han, Yukio Takamatsu, Hideko Yamamoto, Shinya Kasai, Shogo Endo, Tomoaki Shirao, Nobuhiko Kojima, Kazutaka Ikeda   +7 more
doaj   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Ameliorative Effect of Taurine on Nandrolone Decanoate Induced Toxicity on Brain, Heart and Testis in Adult Male Albino Rats [PDF]

Zagazig Journal of Forensic Medicine and Toxicology
Background: The most prescribed anabolic steroid in gym practice is nandrolone decanoate (ND). It is implicated in sport doping, and criminal circles where personal aggressiveness was evident.
Elham Megahed, Dena Abdel Moawed, Sara Abdel Aal, Samar Mohamed, Aliaa Talaat, Ghadeer Abdelaal   +5 more
doaj   +1 more source

Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
The nucleus of the solitary tract (NTS) integrates visceral inputs to coordinate appetite and digestion, breathing, and cardiorespiratory reflexes. Using cell‐type‐specific tracing, we show that excitatory Lmx1b neurons project broadly to brainstem and forebrain targets, whereas inhibitory output remains largely brainstem‐restricted. Catecholaminergic (
Silvia Gasparini, Haidong Zhu, Ana Sofia Peraza Munuzuri, Mya L. Leuang, Frederico S. Fazan, Joel C. Geerling   +5 more
wiley   +1 more source

[3H]dynorphin a binding and [kappa] selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain [PDF]

, 1986
We have previously demonstrated that [3H]dynorphin A selectively labels [kappa] opioid receptors in guinea-pig whole brain. In these current studies, using protection from inactivation by [beta]-chloronaltrexamine ([beta]-CNA), we are able to demonstrate
Walker, J. Michael, Young, Elizabeth A., Lewis, Michael E., Houghten, Richard A., Akil, Huda, Woods, James H.   +5 more
core   +1 more source

Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. [PDF]

PLoS ONE, 2014
Dynorphins, endogenous opioid peptides that arise from the precursor protein prodynorphin (Pdyn), are hypothesized to be involved in the regulation of mood states and the neuroplasticity associated with addiction.
Ami Cohen, Timothy W Whitfield, Max Kreifeldt, Pascale Koebel, Brigitte L Kieffer, Candice Contet, Olivier George, George F Koob   +7 more
doaj   +1 more source

Alcohol dependence, disinhibited behavior and variation in the prodynorphin gene [PDF]

Biological Psychology, 2011
The results of the current analyses present preliminary evidence of an association between putatively functional variation in the prodynorphin (PDYN) gene and a dimensional measure of disinhibited behavior. A 68bp sequence in the core promoter region of the PDYN gene was genotyped in a community sample of 1021 adults aged 30-54.
Janine D, Flory, Carolyn L, Pytte, Yasmin, Hurd, Robert E, Ferrell, Stephen B, Manuck   +4 more
openaire   +2 more sources