Results 31 to 40 of about 3,057 (188)
Influence of sex and genetic background on anxiety-related and stress-induced behaviour of prodynorphin-deficient mice. [PDF]
PLoS ONE, 2012 The role of dynorphin/kappa opioid receptors in epilepsy and addiction are well accepted, but their function in emotional control is not yet fully understood.
Iris Kastenberger +3 more
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Pathological alterations in striatal compartments in the human brain of autism spectrum disorder
Molecular Brain, 2020 The striatum comprises a mosaic structure of striosomal and matrix compartments. Imbalanced neuronal activity between striosomes and matrix is implicated in neurological deficits in psychomotor and limbic functions.
Hsiao-Ying Kuo, Fu-Chin Liu
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, 2001 The effect of the selective dopamine uptake inhibitor 1-[2-[bis(4-flourophenyl)methoxy]ethyl]-4-[3-phenylpropyl]piperazine dihydrochloride (GBR 12909) was examined on prodynorphin gene expression.
FERRI S +3 more
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SCA23 and prodynorphin: is it time for gene retraction? [PDF]
Brain, 2016 Sir, We read with interest the recent publication by Smeets et al. (2015) on the generation of transgenic mouse for autosomal dominant spinocerellar ataxia type 23 (SCA23) expressing human prodynorphin ( PDYN ). The manuscript is very well written and profusely documented and it was well demonstrated that expression of mutant human variant p.Arg212Trp
José Luiz, Pedroso +4 more
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VARIABILITY OF PDYN AND OPRK1 GENES IN FOUR ARGENTINIAN POPULATIONS AND ITS GENETIC ASSOCIATION WITH CLINICAL VARIABLES RELATED TO ACUTE POSTSURGICAL PAIN [PDF]
BAG. Journal of Basic and Applied Genetics, 2022 Several population studies showed an association between variation in pain sensitivity and genetic polymorphisms located in Prodynorphin (PDYN) and Kappa Opioid Receptor (OPRK1) human genes.
Di Santo Meztler G.P. +5 more
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Neurobiology of Pain, 2023 The medial prefrontal cortex (mPFC) consists of a heterogeneous population of neurons that respond to painful stimuli, and our understanding of how different pain models alter these specific mPFC cell types remains incomplete. A distinct subpopulation of
Shudi Zhou, Yuexi Yin, Patrick L. Sheets
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Prodynorphin and Proenkephalin in Cerebrospinal Fluid of Sporadic Creutzfeldt–Jakob Disease [PDF]
International Journal of Molecular Sciences, 2022 Proenkephalin (PENK) and prodynorphin (PDYN) are endogenous opioid peptides mainly produced in the striatum and, to a lesser extent, in the cerebral cortex. Dysregulated metabolism and altered cerebrospinal fluid (CSF) levels of PENK and PDYN have been described in several neurodegenerative diseases.
Abu-Rumeileh S. +11 more
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Sequence and expression of the rat prodynorphin gene. [PDF]
Proceedings of the National Academy of Sciences, 1985 We report here the isolation of a lambda genomic clone that contains the nucleotide sequence coding for the main exon of the rat prodynorphin (proenkephalin B) gene. This exon codes for the majority of the translated region of prodynorphin mRNA including the opioid peptides alpha-neo-endorphin, dynorphin A, and dynorphin B.
O, Civelli +3 more
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DREAM regulates BDNF-dependent spinal sensitization
Molecular Pain, 2010 Background The transcriptional repressor DREAM (downstream regulatory element antagonist modulator) controls the expression of prodynorphin and has been involved in the modulation of endogenous responses to pain.
Mellström Britt +9 more
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Cell & Bioscience, 2020 Background Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating ...
Lin Liu +5 more
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