Results 21 to 30 of about 3,057 (188)
Characterization of the Rat Prodynorphin Gene [PDF]
Molecular Endocrinology, 1989 The structure of full-length rat prodynorphin cDNA and the corresponding gene has been determined. The 2400 base rat prodynorphin mRNA is encoded by four exons. Exons 1 and 2 encode the majority of the 5'-untranslated sequence, while exons 3 and 4 contain the translated region; the entire 3' -untranslated region is contained on exon 4 as well.
J, Douglass +4 more
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Evolution of Proenkephalin and Prodynorphin [PDF]
American Zoologist, 1986 SYNOPSIS. Since the discovery of the enkephalins in 1975, three separate families of opioid peptides have been identified, proopiomelanocortin, proenkephalin, and prodynorphin. The lattertwo have multiple copies of the enkephalin sequence in larger enkephalin containing polypeptides (ECPs).
RANDOLPH V. LEWIS, BRUCE W. ERICKSON
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eLife, 2021 Maintaining stable body temperature through environmental thermal stressors requires detection of temperature changes, relay of information, and coordination of physiological and behavioral responses. Studies have implicated areas in the preoptic area of
Aaron J Norris +4 more
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Functional bias of morphine and oliceridine under conditions of minor injury
Molecular Pain, 2021 Recent reports suggest pain from surgical injury may influence the risks associated with exposure to opioids. In mice, hind-paw incision attenuates morphine-primed reinstatement due to kappa opioid receptor activation by dynorphin.
Chinwe Nwaneshiudu +3 more
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SEQUENCE ANALYSIS SUGGESTS POSITIVE SELECTION ON THE BOVINE PRODYNORPHIN GENE [PDF]
BAG. Journal of Basic and Applied Genetics, 2020 Dynorphin A is an endogenous opioid peptide that is part of the KNDy system in the hypothalamus of mammals. This peptide acts as an inhibitor of the GnRH pulse generation, thus regulating the onset of puberty and reproductive cycles.
Suqueli García M.F. +2 more
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Journal of Neuroinflammation, 2018 Background We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials.
Duy-Khanh Dang +12 more
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Effect of PDYN rs2281285, rs2235749 and rs910080 gene polymorphisms on the intensity of depression symptoms and negative craving in heroin addicts [PDF]
Archives of Biological Sciences, 2021 The present study was undertaken to explore whether prodynorphin (PDYN) polymorphisms have an effect on the intensity of depressive symptoms and negative craving in heroin addicts in a sample of 100 heroin addicts and 108 controls.
Kaya-Akyüzlü Dilek +3 more
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eLife, 2020 Maladaptive responses to stress are a hallmark of alcohol use disorder, but the mechanisms that underlie this are not well characterized. Here, we show that kappa opioid receptor signaling in the bed nucleus of the stria terminalis (BNST) is a critical ...
Lara S Hwa +11 more
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Neurobiology of Disease, 1999 Rats with unilateral dopamine-denervating lesions sustained a 3-week treatment with a daily l-DOPA dose that is in the therapeutic range for Parkinson's disease.
M. Andersson, A. Hilbertson, M.A. Cenci
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Ancient and recent positive selection transformed opioid cis-regulation in humans.
PLoS Biology, 2005 Changes in the cis-regulation of neural genes likely contributed to the evolution of our species' unique attributes, but evidence of a role for natural selection has been lacking.
Matthew V Rockman +5 more
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