Results 11 to 20 of about 3,057 (188)

Prodynorphin peptide immunocytochemistry in rhesus monkey brain [PDF]

Peptides, 1985
The present study describes the immunocytochemical distribution of peptides derived from the prodynorphin precursor in the brain of the rhesus monkey (Macaca mulatta). Animals were treated with colchicine (intracerebroventricularly) prior to perfusion to enhance the observation of perikaryal immunoreactivity.
Khachaturian, Henry, Lewis, Michael E., Haber, Suzanne N., Houghten, Richard A., Akil, Huda, Watson, Stanley J.   +5 more
openaire   +5 more sources

Prodynorphin-Derived Peptides

, 2013
The dynorphin family is composed of multiple peptides generated by posttranslational processing of prodynorphin. They are widely distributed in the central nervous system and occur in peripheral tissues, such as the heart, the gastrointestinal tract, and the adrenal gland.
SPAMPINATO, SANTI MARIO, BEDINI, ANDREA, BAIULA, MONICA   +2 more
core   +4 more sources

Cloning of Prodynorphin cDNAs from the Brain of Australian and African Lungfish: Implications for the Evolution of the Prodynorphin Gene

Neuroendocrinology, 2004
In mammals the opioids Met-enkephalin and Leu-enkephalin are derived from a common precursor, proenkephalin, and as a result these neuropeptides are co-localized in enkephalinergic neurons. The mammalian scheme for enkephalinergic networks is not universal for all classes of sarcopterygian vertebrates.
Robert M, Dores, Cristina, Sollars, Stephanie, Lecaude, Jenny, Lee, Phillip, Danielson, Jasem, Alrubaian, Isabelle, Lihrman, Jean M P, Joss, Hubert, Vaudry   +8 more
openaire   +3 more sources

Stimulus-specific hierarchy of enhancer elements within the rat prodynorphin promoter

, 1998
Induction of the prodynorphin gene occurs in a tissue-specific manner following different physiological stimuli. Using electrophoretic mobility shift assays, we studied the relative activity of the five major regulatory sites in the rat prodynorphin ...
Luckman, Simon M.; id_orcid, Mellström, Britt, Carrión, Angel M., Naranjo, Jose R.   +3 more
core   +10 more sources

Gender-specific association of functional prodynorphin 68 bp repeats with cannabis exposure in an African American cohort

Neuropsychiatric Disease and Treatment, 2018
Vadim Yuferov,* Eduardo R Butelman,* Mary Jeanne Kreek Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA *These authors contributed equally to this work Background: Cannabis use disorders (CUDs) cause ...
Yuferov V, Butelman ER, Kreek MJ
doaj   +1 more source

Prodynorphin-derived peptide expression in primate cortex and striatum [PDF]

Neuropeptides, 1994
The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and alpha-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). alpha-neo-endorphin was the most abundant peptide in both cortex and striatum.
Healy, Daniel J., Meador-Woodruff, James H.   +1 more
core   +6 more sources

Prodynorphin Epialleles

, 2016
Dynorphins, the endogenous ligands for kappa-opioid receptors play an essential role in neuroendocrine regulation, stress response, reward processing, and mood control. These neuropeptides induce strong dysphoric and aversive effects.
Igor Bazov, Georgy Bakalkin
openaire   +2 more sources

Role of PBN-CeA Circuit in Paclitaxel-Induced Neuropathic Pain and Negative Emotions. [PDF]

CNS Neurosci Ther
Paclitaxel‐induced neuropathy recruits the PBN–CeA pathway and increases CeA PDYN expression, contributing to pain hypersensitivity and negative emotional behaviors. Suppressing PBN inputs to the CeA or blocking KOR with Navacaprant mitigates both sensory hypersensitivity and negative emotional symptoms.
Chen H, Chen L, Chen Y, Huang Y, Fan F, Liu Y, Zhang Q, Tang Y, Chen A, Lin C.   +9 more
europepmc   +2 more sources

Dysregulated Plasticity in Serotonin, Galanin, and Opioid Systems Contributes to Limbic Seizure Recruitment in Wistar Audiogenic Rat. [PDF]

J Neurochem
To find molecular reasons why a genetic rat model (Wistar Audiogenic Rat, WAR) moves from sound‐triggered brainstem seizures to longer‐lasting limbic (temporal‐lobe) epilepsy after repeated loud‐noise exposure. WAR and normal Wistar rats received a 10‐day audiogenic kindling (twice‐daily loud noise).
Camilo TA, Valentim-Lima E, de Oliveira JAC, Garcia-Cairasco N, Reis LC, Nani JV, Mecawi AS.   +6 more
europepmc   +2 more sources

Whole‐brain cell‐cell interaction patterns explain tissue damage in several neurodegenerative conditions [PDF]

Alzheimers Dement
Abstract Background Disrupted interactions among neurons, glial and vascular cell types can lead to inflammation, vascular dysfunction, and neuronal death, highlighting the need to understand how functional interactions between these cells predispose the development of different neurodegenerative conditions.
Pak V, Hong J, Bezgin G, Dadar M, Zeighami Y, Medina Y.   +5 more
europepmc   +4 more sources