Results 41 to 50 of about 2,309 (192)

The role of BDNF/TrkB signaling in acute amphetamine-induced locomotor activity and opioid peptide gene expression in the rat dorsal striatum

Frontiers in Systems Neuroscience, 2011
Exposure to psychostimulants increases brain-derived neurotrophic factor (BDNF) mRNA and protein levels in the cerebral cortex and subcortical structures.
Jacqueline F McGinty, Alexandra J Bache, Nortorious T Coleman, Wei-Lun eSun   +3 more
doaj   +1 more source

Preproenkephalin Knockout Mice Show No Depression-Related Phenotype [PDF]

Neuropsychopharmacology, 2007
Clinical, preclinical, and pharmacological studies have suggested that decreased enkephalin tone is associated with depression-like symptoms and increase in enkephalin signaling could have a therapeutic value in the treatment of depression. In this study we demonstrate that, surprisingly, animals lacking enkephalin (preproenkephalin, Penk1(-/-)) showed
Andras, Bilkei-Gorzo, Kerstin, Michel, Florence, Noble, Bernard P, Roques, Andreas, Zimmer   +4 more
openaire   +2 more sources

Resolving pathobiological mechanisms relating to Huntington disease: Gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells

Neurobiology of Disease, 2014
Progressive cell loss is observed in the striatum, cerebral cortex, thalamus, hypothalamus, subthalamic nucleus and hippocampus in Huntington disease. In the striatum, dopamine-responsive medium spiny neurons are preferentially lost.
Hyun Ah. Kim, Luning Jiang, Heather Madsen, Clare L. Parish, Jim Massalas, Arthur Smardencas, Claire O'Leary, Ilse Gantois, Colm O'Tuathaigh, John L. Waddington, Michelle E. Ehrlich, Andrew J. Lawrence, John Drago   +12 more
doaj   +1 more source

Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene

, 2005
It has been shown previously that the endogenous opioid system may be involved in the behavioral effects of nicotine. In the present study, the participation of endogenous enkephalins on nicotine responses has been investigated by using preproenkephalin ...
Mendizábal, Victoria, Maldonado, Rafael, 1961-, Berrendero Díaz, Fernando, 1971-, Bilkei Gorzo, Andras, Robledo, Patricia, 1958-, Galeote González, Lola, Zimmer, Andreas   +6 more
core   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet.

PLoS ONE, 2014
ObjectiveLeptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high-sugar (fcHFHS) diet are resistant to peripherally administered leptin. The aim of this study was to investigate feeding responses to central leptin as well as
José K van den Heuvel, Leslie Eggels, Eric Fliers, Andries Kalsbeek, Roger A H Adan, Susanne E la Fleur   +5 more
doaj   +1 more source

Translation of heart preproenkephalin mRNA and secretion of enkephalin peptides from cultured cardiac myocytes

, 1992
Rat ventricular cardiac muscle has previously been shown to contain exceptionally high levels of preproenkephalin mRNA (ppEnk mRNA). We have recently determined that the level of ppEnk mRNA is developmentally and hormonally regulated in rat ventricular ...
W. C. Claycomb, J. P. Springhorn
core   +1 more source

The pyrogenic mediator prostaglandin E2 elicits warmth seeking via EP3 receptor‐expressing parabrachial neurons: a potential mechanism of chills

The Journal of Physiology, Volume 604, Issue 5, Page 2110-2130, 1 March 2026.
Abstract figure legend During infection, prostaglandin E2 (PGE2) is produced and elicits warmth‐seeking behaviour and involuntary febrile responses by acting on prostaglandin EP3 receptors (EP3Rs) in two distinct brain sites. PGE2 acting on EP3Rs on neurons in the external lateral part of the lateral parabrachial nucleus (LPBel) augments cold sensory ...
Takaki Yahiro, Yoshiko Nakamura, Kazuhiro Nakamura   +2 more
wiley   +1 more source

Expression of preproenkephalin mRNA by cultured astrocytes and neurons. [PDF]

Proceedings of the National Academy of Sciences, 1988
Expression of preproenkephalin mRNA by developing glia and neurons was examined in cultures of embryonic and neonatal rat brain. Cultured glia from specific regions of embryonic day 17 and neonatal day 1 rat brain were identified as astrocytes on the basis of both morphology and expression of immunoreactivity for glial fibrillary acidic protein.
M H, Vilijn, P J, Vaysse, R S, Zukin, J A, Kessler   +3 more
openaire   +2 more sources

Extracellular Vesicles Derived From Mesenchymal Bone Marrow Cells Promote Antinociception in a Murine Model of Diabetic Neuropathy via the Endogenous Opioid System

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
This study investigates the analgesic potential of extracellular vesicles derived from bone marrow mesenchymal stem cells (EV‐BMSC) in diabetic sensory neuropathy. EV‐BMSC reproduce the pain‐relieving effects of BMSC transplantation through opioid‐mediated mechanisms, highlighting a promising cell‐free therapeutic approach for neuropathic pain ...
Gessica S. A. Silva, Afrânio F. Evangelista, Girlaine C. Santos, Thaís A. Santana, Luiza C. F. Opretzka, Pedro S. S. Lauria, Marco A. Stimamiglio, Milena B. P. Soares, Cristiane F. Villarreal   +8 more
wiley   +1 more source