Results 21 to 30 of about 2,094 (191)

Neprilysin inhibition does not alter dynamic of proenkephalin‐A 119‐159 and pro‐substance P in heart failure

ESC Heart Failure, Volume 8, Issue 3, Page 2016-2024, June 2021., 2021
Abstract Aims As NEP degrades many substrates, the specific therapeutic mechanism of NEP inhibition with angiotensin receptor neprilysin inhibitor (ARNi) in heart failure with reduced ejection fraction (HFrEF) is not entirely evident. The aim of this study was to investigate the response of two substrates of NEP—the tachykinin and enkephalin systems—to
Henrike Arfsten, Georg Goliasch, Philipp E. Bartko, Suriya Prausmüller, Georg Spinka, Anna Cho, Johannes Novak, Julia Mascherbauer, Helmuth Haslacher, Guido Strunk, Martin Hülsmann, Noemi Pavo   +11 more
wiley   +1 more source

Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model

Molecular Pain, 2008
Background A chronic pancreatitis model was developed in young male Lewis rats fed a high-fat and alcohol liquid diet beginning at three weeks. The model was used to assess time course and efficacy of a replication defective herpes simplex virus type 1 ...
Ren Yong, Lu Ying, Chu Rong, McNearney Terry A, Yang Hong, Yeomans David C, Wilson Steven P, Westlund Karin N   +7 more
doaj   +1 more source

Morphine alters preproenkephalin gene expression

Brain Research, 1988
Rats made tolerant/dependent to morphine by s.c. implantation of drug pellets displayed a significant decrease in striatal preproenkephalin mRNA that persisted during the period of withdrawal. Levels of Met-enkephalin were normal at the end of treatment, but reduced after withdrawal.
G R, Uhl, J P, Ryan, J P, Schwartz
openaire   +2 more sources

Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes

Neurobiology of Disease, 2008
Coadministration of entacapone with levodopa attenuates motor complications in experimental models of Parkinson's disease. The mechanisms underlying entacapone effects are unknown. We investigated the effect of entacapone, on: long-duration response (LDR)
C. Marin, E. Aguilar, G. Mengod, R. Cortés, M.C. Rodríguez-Oroz, J.A. Obeso   +5 more
doaj   +1 more source

Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist–induced orofacial dyskinesia

JCI Insight, 2021
Antipsychotics often cause tardive dyskinesia, an adverse symptom of involuntary hyperkinetic movements. Analysis of the US Food and Drug Administration Adverse Event Reporting System and JMDC insurance claims revealed that acetaminophen prevented the ...
Koki Nagaoka, Takuya Nagashima, Nozomi Asaoka, Hiroki Yamamoto, Chihiro Toda, Gen Kayanuma, Soni Siswanto, Yasuhiro Funahashi, Keisuke Kuroda, Kozo Kaibuchi, Yasuo Mori, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko   +13 more
doaj   +1 more source

The opioid agonist morphine decreases the dyskinetic response to dopaminergic agents in parkinsonian monkeys

Neurobiology of Disease, 2004
In parkinsonian patients as well as in primate models with levodopa-induced dyskinesias (LID), an increase in the expression of preproenkephalin in the striatal output pathways has been demonstrated.
Pershia Samadi, Laurent Grégoire, Paul J Bédard   +2 more
doaj   +1 more source

Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson’s disease

Neurobiology of Disease, 2007
l-DOPA-induced dyskinesia (LID) is one of the main limitations of long term l-DOPA use in Parkinson’s disease (PD) patients. We show that chronic l-DOPA treatment induces novel dyskinetic behaviors in aphakia mouse with selective nigrostriatal deficit ...
Yunmin Ding, Jacqueline Restrepo, Lisa Won, Dong-Youn Hwang, Kwang-Soo Kim, Un Jung Kang   +5 more
doaj   +1 more source

Compensatory regulation of striatal neuropeptide gene expression occurs before changes in metabolic activity of basal ganglia nuclei

Neurobiology of Disease, 2003
Compensatory mechanisms delay the appearance of parkinsonian symptoms. However, both the order of appearance and potential interactions of compensatory mechanisms acting within the nigrostriatal pathway as well as inside and outside the basal ganglia are
Wassilios Meissner, Sandra Dovero, Bernard Bioulac, Christian E. Gross, Erwan Bezard   +4 more
doaj   +1 more source

Upregulation of Striatal Preproenkephalin Gene Expression Occurs before the Appearance of Parkinsonian Signs in 1-Methyl-4-phenyl- 1,2,3,6-tetrahydropyridine Monkeys

Neurobiology of Disease, 2001
GABA and enkephalin-utilizing efferents from the striatum to the external segment of the pallidal complex (GPe) are thought to be overactive in Parkinson's disease (PD).
Erwan Bezard, Paula Ravenscroft, Christian E. Gross, Alan R. Crossman, Jonathan M. Brotchie   +4 more
doaj   +1 more source

Transcriptome markers of viral persistence in naturally-infected andes virus (bunyaviridae) seropositive long-tailed pygmy rice rats. [PDF]

PLoS ONE, 2015
Long-tailed pygmy rice rats (Oligoryzomys longicaudatus) are principal reservoir hosts of Andes virus (ANDV) (Bunyaviridae), which causes most hantavirus cardiopulmonary syndrome cases in the Americas.
Corey L Campbell, Fernando Torres-Perez, Mariana Acuna-Retamar, Tony Schountz   +3 more
doaj   +1 more source