Results 21 to 30 of about 2,309 (192)

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

Current Insights on Bioactive Molecules, Antioxidant, Anti‐Inflammatory, and Other Pharmacological Activities of Cinnamomum camphora Linn

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
C. camphora is a renowned traditional Unani medicinal herb and belongs to the family Lauraceae. It has therapeutic applications in various ailments and prophylactic properties to prevent flu‐like epidemic symptoms and COVID‐19. This comprehensive appraisal is to familiarize the reader with the traditional, broad applications of camphor both in Unani ...
Mohamed Joonus Aynul Fazmiya, Arshiya Sultana, Khaleequr Rahman, Md Belal Bin Heyat, Sumbul, Faijan Akhtar, Salabat Khan, Seth Christopher Yaw Appiah, Tarique Hussain   +8 more
wiley   +1 more source

Neprilysin inhibition does not alter dynamic of proenkephalin‐A 119‐159 and pro‐substance P in heart failure

ESC Heart Failure, Volume 8, Issue 3, Page 2016-2024, June 2021., 2021
Abstract Aims As NEP degrades many substrates, the specific therapeutic mechanism of NEP inhibition with angiotensin receptor neprilysin inhibitor (ARNi) in heart failure with reduced ejection fraction (HFrEF) is not entirely evident. The aim of this study was to investigate the response of two substrates of NEP—the tachykinin and enkephalin systems—to
Henrike Arfsten, Georg Goliasch, Philipp E. Bartko, Suriya Prausmüller, Georg Spinka, Anna Cho, Johannes Novak, Julia Mascherbauer, Helmuth Haslacher, Guido Strunk, Martin Hülsmann, Noemi Pavo   +11 more
wiley   +1 more source

Morphine alters preproenkephalin gene expression

Brain Research, 1988
Rats made tolerant/dependent to morphine by s.c. implantation of drug pellets displayed a significant decrease in striatal preproenkephalin mRNA that persisted during the period of withdrawal. Levels of Met-enkephalin were normal at the end of treatment, but reduced after withdrawal.
G R, Uhl, J P, Ryan, J P, Schwartz
openaire   +2 more sources

Regulatory T Cells for Stroke Recovery: A Promising Immune Therapeutic Strategy. [PDF]

CNS Neurosci Ther
Both adoptive transfer of the expanded Tregs and increasing Treg numbers via agents that can stimulate endogenous Treg proliferation are therapeutic strategies for enhancing Treg levels in stroke. Tregs play a crucial role in neuroprotection and functional recovery after stroke by restoring the integrity of the blood–brain barrier, suppressing the ...
Li N, Wang H, Hu C, Qie S, Liu Z.
europepmc   +2 more sources

Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist–induced orofacial dyskinesia

JCI Insight, 2021
Antipsychotics often cause tardive dyskinesia, an adverse symptom of involuntary hyperkinetic movements. Analysis of the US Food and Drug Administration Adverse Event Reporting System and JMDC insurance claims revealed that acetaminophen prevented the ...
Koki Nagaoka, Takuya Nagashima, Nozomi Asaoka, Hiroki Yamamoto, Chihiro Toda, Gen Kayanuma, Soni Siswanto, Yasuhiro Funahashi, Keisuke Kuroda, Kozo Kaibuchi, Yasuo Mori, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko   +13 more
doaj   +1 more source

Depolarization regulates adrenal preproenkephalin mRNA. [PDF]

Proceedings of the National Academy of Sciences, 1985
The regulation of neuropeptide gene expression has been investigated by using rat adrenal medullae grown in explant culture. After 3 days in culture the (now denervated) explants exhibited a 10-fold increase in leucine-enkephalin (leu-EK) content. Inhibition of protein synthesis with cycloheximide completely blocked the rise, whereas inhibition of RNA ...
E F, LaGamma, J D, White, J E, Adler, J E, Krause, J F, McKelvy, I B, Black   +5 more
openaire   +2 more sources

The opioid agonist morphine decreases the dyskinetic response to dopaminergic agents in parkinsonian monkeys

Neurobiology of Disease, 2004
In parkinsonian patients as well as in primate models with levodopa-induced dyskinesias (LID), an increase in the expression of preproenkephalin in the striatal output pathways has been demonstrated.
Pershia Samadi, Laurent Grégoire, Paul J Bédard   +2 more
doaj   +1 more source

Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson’s disease

Neurobiology of Disease, 2007
l-DOPA-induced dyskinesia (LID) is one of the main limitations of long term l-DOPA use in Parkinson’s disease (PD) patients. We show that chronic l-DOPA treatment induces novel dyskinetic behaviors in aphakia mouse with selective nigrostriatal deficit ...
Yunmin Ding, Jacqueline Restrepo, Lisa Won, Dong-Youn Hwang, Kwang-Soo Kim, Un Jung Kang   +5 more
doaj   +1 more source

Compensatory regulation of striatal neuropeptide gene expression occurs before changes in metabolic activity of basal ganglia nuclei

Neurobiology of Disease, 2003
Compensatory mechanisms delay the appearance of parkinsonian symptoms. However, both the order of appearance and potential interactions of compensatory mechanisms acting within the nigrostriatal pathway as well as inside and outside the basal ganglia are
Wassilios Meissner, Sandra Dovero, Bernard Bioulac, Christian E. Gross, Erwan Bezard   +4 more
doaj   +1 more source