Results 11 to 20 of about 2,309 (192)

Transcriptional Regulatory Role of NELL2 in Preproenkephalin Gene Expression. [PDF]

Mol Cells, 2022
Preproenkephalin (PPE) is a precursor molecule for multiple endogenous opioid peptides Leu-enkephalin (ENK) and Met-ENK, which are involved in a wide variety of modulatory functions in the nervous system. Despite the functional importance of ENK in the brain, the effect of brain-derived factor(s) on PPE expression is unknown.
Ha CM, Kim DH, Lee TH, Kim HR, Choi J, Kim Y, Kang D, Park JW, Ojeda SR, Jeong JK, Lee BJ.   +10 more
europepmc   +4 more sources

Differential expression of preproenkephalin and preprodynorphin mRNAs in striatal neurons: high levels of preproenkephalin expression depend on cerebral cortical afferents [PDF]

The Journal of Neuroscience, 1988
Preproenkephalin and preprodynorphin mRNAs can be detected by in situ hybridization in medium-sized striatal neurons in normal rats and in rats with unilateral cerebral cortical lesions. Hybridization of 35S- labeled oligonucleotide cDNAs complementary to specific regions of each mRNA reveals that preproenkephalin-expressing neurons are more numerous ...
G R, Uhl, B, Navia, J, Douglas
openaire   +3 more sources

Distribution of preproenkephalin mRNA in the chicken and pigeon telencephalon

Journal of Comparative Neurology, 1994
AbstractBioassay and immunological studies have detected the presence of opioid peptides in the nervous system of representatives of all classes of vertebrates. The present study evaluates the expression and localization of preproenkephalin (PPE) mRNA to determine the sites of synthesis of the enkephalin peptides in the adult chicken and pigeon ...
MOLNAR M, CASINI, GIOVANNI, DAVIS BM, BAGNOLI, PAOLA, BRECHA N.   +4 more
openaire   +4 more sources

Effect of Repeatedl-DOPA, Bromocriptine, or Lisuride Administration on Preproenkephalin-A and Preproenkephalin-B mRNA Levels in the Striatum of the 6-Hydroxydopamine-Lesioned Rat

Experimental Neurology, 1999
Abnormal involuntary movements, or dyskinesias, plague current symptomatic approaches to the treatment of Parkinson's disease. The neural mechanisms underlying the generation of dyskinesia following repeated l-3,4-dihydroxyphenylalanine (L-DOPA) or dopamine agonist administration in Parkinson's disease remain unknown. However, de novo administration of
Henry, Brian, Crossman, Alan R., Brotchie, Jonathan M.   +2 more
openaire   +3 more sources

Preproenkephalin Gene and mRNA [Elektronisk resurs] : Studies of Structure, Function, Cocaine Responses in an Animal Model, and Genetic Association with Human Opiate Addiction

, 2004
The endogenous opioid enkephalin neuropeptides are mediators of pain perception and have been implicated in human addictions. The preproenkephalin gene and its mRNA have also provided many examples of tissue- and species-specific variations in mRNA ...
LaForge, Karl Steven,, Nyberg, Fred, Eriksson, Peter S.,   +2 more
core   +7 more sources

Chemically Fueled Communication Along a Scaffolded Nanoscale Array of Squaramides

Angewandte Chemie, Volume 135, Issue 38, September 18, 2023., 2023
A two nanometer‐long molecular device has been synthesised that contains a rigid rod ‐ to provide structural definition ‐ attached to a molecular relay that switches direction in response to an incoming signal. Like natural systems, it responds to temporal changes in a signal, exemplified by the consumption of a molecular fuel, changes that are ...
Luis Martínez‐Crespo, Iñigo J. Vitórica‐Yrezábal, George F. S. Whitehead, Simon J. Webb   +3 more
wiley   +2 more sources

The structure and expression of the preproenkephalin gene [PDF]

Nucleic Acids Research, 1982
Enkephalins are pentapeptides with opioid activity which are found in a wide variety of tissues. Studies of enkephalin-containing peptides from the adrenal gland have established that the mature pentapeptides are derived by proteolytic processing of a precursor protein.
Legon, Steve, Glover, David M., Hughes, John, Lowry, Philip J., Rigby, Peter W. J., Watson, Christine J.   +5 more
openaire   +3 more sources

The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders

British Journal of Pharmacology, Volume 180, Issue 7, Page 879-893, April 2023., 2023
Despite the increasing impact of opioid use disorders on society, there is a disturbing lack of effective medications for their clinical management. An interesting innovative strategy to treat these disorders consists in the protection of endogenous opioid peptides to activate opioid receptors, avoiding the classical opioid‐like side effects.
Beltran Alvarez‐Perez, Hervé Poras, Rafael Maldonado   +2 more
wiley   +1 more source

A compendium of validated pain genes

WIREs Mechanisms of Disease, Volume 14, Issue 6, November/December 2022., 2022
An overview of pain signaling pathways, with tissue expression patterns of 242 validated pain genes. Abstract The development of novel pain therapeutics hinges on the identification and rigorous validation of potential targets. Model organisms provide a means to test the involvement of specific genes and regulatory elements in pain.
Eric Wistrom, Rebecca Chase, Patrick R. Smith, Zachary T. Campbell   +3 more
wiley   +1 more source

Kappa opioids inhibit the GABA/glycine terminals of rostral ventromedial medulla projections in the superficial dorsal horn of the spinal cord

The Journal of Physiology, Volume 600, Issue 18, Page 4187-4205, 15 September 2022., 2022
Abstract figure legend We combined ex vivo optogenetic stimulation of RVM fibres with whole cell electrophysiology of SDH neurons to investigate the final synapse in a key descending pain modulatory pathway. We demonstrate that both glycine and GABA mediate signalling at the RVM‐SDH synapse, that the SDH targets of RVM projections have diverse ...
Yo Otsu, Karin R. Aubrey
wiley   +1 more source