Results 11 to 20 of about 2,094 (191)
Differential expression of preproenkephalin and preprodynorphin mRNAs in striatal neurons: high levels of preproenkephalin expression depend on cerebral cortical afferents [PDF]
The Journal of Neuroscience, 1988 Preproenkephalin and preprodynorphin mRNAs can be detected by in situ hybridization in medium-sized striatal neurons in normal rats and in rats with unilateral cerebral cortical lesions. Hybridization of 35S- labeled oligonucleotide cDNAs complementary to specific regions of each mRNA reveals that preproenkephalin-expressing neurons are more numerous ...
G R, Uhl, B, Navia, J, Douglas
openaire +3 more sources
, 2004 The endogenous opioid enkephalin neuropeptides are mediators of pain perception and have been implicated in human addictions. The preproenkephalin gene and its mRNA have also provided many examples of tissue- and species-specific variations in mRNA ...
LaForge, Karl Steven, +2 more
core +9 more sources
Chemically Fueled Communication Along a Scaffolded Nanoscale Array of Squaramides
Angewandte Chemie, Volume 135, Issue 38, September 18, 2023., 2023 A two nanometer‐long molecular device has been synthesised that contains a rigid rod ‐ to provide structural definition ‐ attached to a molecular relay that switches direction in response to an incoming signal. Like natural systems, it responds to temporal changes in a signal, exemplified by the consumption of a molecular fuel, changes that are ...
Luis Martínez‐Crespo +3 more
wiley +2 more sources
British Journal of Pharmacology, Volume 180, Issue 7, Page 879-893, April 2023., 2023 Despite the increasing impact of opioid use disorders on society, there is a disturbing lack of effective medications for their clinical management. An interesting innovative strategy to treat these disorders consists in the protection of endogenous opioid peptides to activate opioid receptors, avoiding the classical opioid‐like side effects.
Beltran Alvarez‐Perez +2 more
wiley +1 more source
A compendium of validated pain genes
WIREs Mechanisms of Disease, Volume 14, Issue 6, November/December 2022., 2022 An overview of pain signaling pathways, with tissue expression patterns of 242 validated pain genes. Abstract The development of novel pain therapeutics hinges on the identification and rigorous validation of potential targets. Model organisms provide a means to test the involvement of specific genes and regulatory elements in pain.
Eric Wistrom +3 more
wiley +1 more source
The Journal of Physiology, Volume 600, Issue 18, Page 4187-4205, 15 September 2022., 2022 Abstract figure legend We combined ex vivo optogenetic stimulation of RVM fibres with whole cell electrophysiology of SDH neurons to investigate the final synapse in a key descending pain modulatory pathway. We demonstrate that both glycine and GABA mediate signalling at the RVM‐SDH synapse, that the SDH targets of RVM projections have diverse ...
Yo Otsu, Karin R. Aubrey
wiley +1 more source
Regulatory T Cells for Stroke Recovery: A Promising Immune Therapeutic Strategy. [PDF]
CNS Neurosci TherBoth adoptive transfer of the expanded Tregs and increasing Treg numbers via agents that can stimulate endogenous Treg proliferation are therapeutic strategies for enhancing Treg levels in stroke. Tregs play a crucial role in neuroprotection and functional recovery after stroke by restoring the integrity of the blood–brain barrier, suppressing the ...
Li N, Wang H, Hu C, Qie S, Liu Z.
europepmc +2 more sources
Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022 By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari +4 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 C. camphora is a renowned traditional Unani medicinal herb and belongs to the family Lauraceae. It has therapeutic applications in various ailments and prophylactic properties to prevent flu‐like epidemic symptoms and COVID‐19. This comprehensive appraisal is to familiarize the reader with the traditional, broad applications of camphor both in Unani ...
Mohamed Joonus Aynul Fazmiya +8 more
wiley +1 more source
Depolarization regulates adrenal preproenkephalin mRNA. [PDF]
Proceedings of the National Academy of Sciences, 1985 The regulation of neuropeptide gene expression has been investigated by using rat adrenal medullae grown in explant culture. After 3 days in culture the (now denervated) explants exhibited a 10-fold increase in leucine-enkephalin (leu-EK) content. Inhibition of protein synthesis with cycloheximide completely blocked the rise, whereas inhibition of RNA ...
E F, LaGamma +5 more
openaire +2 more sources