Results 31 to 40 of about 2,094 (191)

Spatial distribution of D1R- and D2R-expressing medium-sized spiny neurons differs along the rostro-caudal axis of the mouse dorsal striatum

Frontiers in Neural Circuits, 2013
The striatum projection neurons are striatonigral and striatopallidal medium sized-spiny neurons (MSNs) that preferentially express D1 (D1R) and D2 (D2R) dopamine receptors, respectively.
Giuseppe eGangarossa, Giuseppe eGangarossa, Giuseppe eGangarossa, Julie eEspallergues, Julie eEspallergues, Julie eEspallergues, Philippe eMailly, Philippe eMailly, Philippe eMailly, Dimitri eDe Bundel, Dimitri eDe Bundel, Dimitri eDe Bundel, Alban eDe Kerchove D'Exaerde, Denis eHervé, Denis eHervé, Denis eHervé, Jean-Antoine eGirault, Jean-Antoine eGirault, Jean-Antoine eGirault, Emmanuel eValjent, Emmanuel eValjent, Emmanuel eValjent, Patrik eKrieger   +22 more
doaj   +1 more source

Reward associated with singing behavior correlates with opioid-related gene expression in the medial preoptic nucleus in male European starlings. [PDF]

PLoS ONE, 2014
Birdsong consists of species-specific learned vocal sequences that are used primarily to attract mates and to repel competitors during the breeding season.
Lauren V Riters, Sharon A Stevenson, M Susan DeVries, Melissa A Cordes   +3 more
doaj   +1 more source

Targeted Cell Reprogramming Produces Analgesic Chromaffin-Like Cells from Human Mesenchymal Stem Cells

Cell Transplantation, 2013
Transplantation of allogeneic adrenal chromaffin cells demonstrated the promise of favorable outcomes for pain relief in patients. However, there is a very limited availability of suitable human adrenal gland tissues, genetically well-matched donors in ...
T. Qu M.D., Ph.D., G. Shi, K. Ma, H. N. Yang, W. M. Duan, G. D. Pappas   +5 more
doaj   +1 more source

Distribution of glutamate and preproenkephalin messenger RNAs following transient focal cerebral ischemia

, 1999
Middle cerebral artery occlusion may result in increased activation of N-methyl- d-aspartate- or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type receptors by glutamate and lead to neuronal cell death.
L. Belayev, M.D. Ginsberg, Belayev, L, Friedman, L.K, Alfonso, O.F, Ginsberg, M.D, L.K. Friedman, O.F. Alfonso   +7 more
core   +1 more source

Anxiety- and depressive-like responses and c-fos activity in preproenkephalin klockout mice: Oversensitivity hypothesis of enkephalin deficit-induced posttraumatic stress disorder

Journal of Biomedical Science, 2010
The present study used the preproenkephalin knockout (ppENK) mice to test whether the endogenous enkephalins deficit could facilitate the anxiety- and depressive-like symptoms of posttraumatic stress disorder (PTSD).
Shyu Bai-Chuang, Chen Tsung-Chieh, Kung Jen-Chuang, Hsiao Sigmund, Huang Andrew   +4 more
doaj   +1 more source

Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver

, 1995
Cholestatic liver disease is associated with clinical and experimental findings consistent with increased opioidergic neuromodulation, increased plasma total opioid activity, and elevated plasma enkephalin concentrations. In contrast to the normal adult
S. L. Sabol, W. S. Young, N. V. Bergasa, D. E. Kleiner, E. A. Jones   +4 more
core   +1 more source

The role of BDNF/TrkB signaling in acute amphetamine-induced locomotor activity and opioid peptide gene expression in the rat dorsal striatum

Frontiers in Systems Neuroscience, 2011
Exposure to psychostimulants increases brain-derived neurotrophic factor (BDNF) mRNA and protein levels in the cerebral cortex and subcortical structures.
Jacqueline F McGinty, Alexandra J Bache, Nortorious T Coleman, Wei-Lun eSun   +3 more
doaj   +1 more source

Detection of the messenger RNA coding for preproenkephalin A in bovine adrenal by in situ hybridization.

, 1984
International audienceThe messenger RNA (mRNA) coding for the adrenal precursor of enkephalins (preproenkephalin-A) has been detected in bovine adrenal medulla cells using in situ hybridization with 32P-labelled preproenkephalin A (PPA) complementary DNA.
Bloom, Fe, Leguellec, D., Reymond, C., Milner, Rj, Baird, A., Bohlen, P., Bloch, B., Gubler, U.   +7 more
core   +2 more sources

Preproenkephalin Knockout Mice Show No Depression-Related Phenotype [PDF]

Neuropsychopharmacology, 2007
Clinical, preclinical, and pharmacological studies have suggested that decreased enkephalin tone is associated with depression-like symptoms and increase in enkephalin signaling could have a therapeutic value in the treatment of depression. In this study we demonstrate that, surprisingly, animals lacking enkephalin (preproenkephalin, Penk1(-/-)) showed
Andras, Bilkei-Gorzo, Kerstin, Michel, Florence, Noble, Bernard P, Roques, Andreas, Zimmer   +4 more
openaire   +2 more sources

Resolving pathobiological mechanisms relating to Huntington disease: Gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells

Neurobiology of Disease, 2014
Progressive cell loss is observed in the striatum, cerebral cortex, thalamus, hypothalamus, subthalamic nucleus and hippocampus in Huntington disease. In the striatum, dopamine-responsive medium spiny neurons are preferentially lost.
Hyun Ah. Kim, Luning Jiang, Heather Madsen, Clare L. Parish, Jim Massalas, Arthur Smardencas, Claire O'Leary, Ilse Gantois, Colm O'Tuathaigh, John L. Waddington, Michelle E. Ehrlich, Andrew J. Lawrence, John Drago   +12 more
doaj   +1 more source