Results 51 to 60 of about 2,094 (191)

Hypoxia‐inducible factor‐2 stabilization is not sufficient to induce erythropoietin production in deeper medullary fibroblasts

The Journal of Physiology, Volume 603, Issue 19, Page 5777-5804, October 1, 2025.
Abstract figure legend Renal erythropoietin (EPO) production was analysed in anaemic and PHD‐inhibitor‐treated wild‐type mice, and mice with genetic fibroblast‐specific hypoxia‐inducible factor (HIF)‐2 stabilization. We found, that PHD inhibition activated HIF‐2 signalling in interstitial fibroblasts of all kidney zones as observed by the induction of ...
Bettina K. M. Firmke, Michaela A. A. Fuchs, Lena M. Süß, Anna‐Lena Forst, Armin Kurtz, Katharina A.‐E. Broeker   +5 more
wiley   +1 more source

A preproenkephalin—Neurofilament chimeric promoter in a helper virus-free herpes simplex virus vector enhances long-term expression in the rat striatum

Neurobiology of Disease, 2004
Helper virus-free herpes simplex virus (HSV-1) plasmid vectors are an attractive system for gene transfer into neurons in the brain, but promoters that support long-term, neuronal-specific expression are required.
Xiaodan Wang, Lingxin Kong, Guo-rong Zhang, Mei Sun, Alfred I Geller   +4 more
doaj   +1 more source

Disease‐Modifying Trials in Treated Parkinson's Disease: “Stable Treated” Does Not Equate with Biological Stability

Movement Disorders, Volume 40, Issue 9, Page 1778-1790, September 2025.
Abstract Traditionally, clinical trials of putative disease‐modifying therapies in Parkinson's disease have enrolled untreated patients at the earliest clinical stages of their disease. Due to a number of challenges inherent with this approach, there has been a recent move to a different study design, enrolling patients who are already taking “stable ...
M. Maral Mouradian, A. Jon Stoessl, Anthony E. Lang   +2 more
wiley   +1 more source

Preproenkephalin Gene and mRNA : Studies of Structure, Function, Cocaine Responses in an Animal Model, and Genetic Association with Human Opiate Addiction

, 2004
The endogenous opioid enkephalin neuropeptides are mediators of pain perception and have been implicated in human addictions. The preproenkephalin gene and its mRNA have also provided many examples of tissue- and species-specific variations in mRNA ...
LaForge, Karl Steven
core   +2 more sources

Expression of preproenkephalin mRNA by cultured astrocytes and neurons. [PDF]

Proceedings of the National Academy of Sciences, 1988
Expression of preproenkephalin mRNA by developing glia and neurons was examined in cultures of embryonic and neonatal rat brain. Cultured glia from specific regions of embryonic day 17 and neonatal day 1 rat brain were identified as astrocytes on the basis of both morphology and expression of immunoreactivity for glial fibrillary acidic protein.
M H, Vilijn, P J, Vaysse, R S, Zukin, J A, Kessler   +3 more
openaire   +2 more sources

The role of the endogenous opioid system in modulating orthodontic‐induced neurogenic inflammation of the dental pulp: A comprehensive review of the literature

International Endodontic Journal, Volume 58, Issue 8, Page 1126-1145, August 2025.
Abstract Background Orthodontic forces may lead to neurogenic inflammation in the dental pulp by triggering the release of somatosensory neuropeptides such as Substance P (SP), Calcitonin gene‐related peptide (CGRP) and Neurokinin A (NKA). In the vast majority of patients, acute symptoms are not triggered, probably due to the control of the neurogenic ...
Javier Caviedes‐Bucheli, Nestor Rios‐Osorio, Esteban Ulate‐Rodríguez, Hernan Dario Muñoz‐Alvear, José F. Gaviño‐Orduña, P. Sebastian Ortolani‐Seltenerich, Jose F. Gomez‐Sosa, Hugo Roberto Munoz   +7 more
wiley   +1 more source

Preproenkephalin messenger RNA—containing neurons in striatum of patients with symptomatic and presymptomatic huntington's disease: An in situ hybridization study [PDF]

, 1991
Previous studies have revealed a loss of enkephalin immunoreactivity in the terminals of striatal neurons projecting to the external globus pallidus in patients with early grades of Huntington's disease (HD).
Young, Anne B., Qin, Ying, Albin, Roger L., Penney, John B., Chesselet, Marie-Francoise   +4 more
core   +1 more source

Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin

Molecular Pain, 2010
Background In pain processing, long term synaptic changes play an important role, especially during chronic pain. The immediate early gene Arc/Arg3.1 has been widely implicated in mediating long-term plasticity in telencephalic regions, such as the ...
Kuhl Dietmar, Biesheuvel Karla, Jongen Joost LM, Hossaini Mehdi, Holstege Jan C   +4 more
doaj   +1 more source

A Comprehensive Review on LncRNAs/miRNAs‐DNMT1 Axis in Human Cancer: Mechanistic and Clinical Application

Journal of Cellular and Molecular Medicine, Volume 29, Issue 10, May 2025.
ABSTRACT Cancer constitutes a significant public health concern, and addressing the challenge of cancer holds paramount importance and requires immediate attention. Epigenetic alterations, encompassing DNA methylation, have emerged as pivotal contributors to the development of diverse cancer types.
Seyed Mohsen Aghaei‐Zarch, Ali Esmaeili, Saeid Bagheri‐Mohammadi   +2 more
wiley   +1 more source

Translation of heart preproenkephalin mRNA and secretion of enkephalin peptides from cultured cardiac myocytes

, 1992
Rat ventricular cardiac muscle has previously been shown to contain exceptionally high levels of preproenkephalin mRNA (ppEnk mRNA). We have recently determined that the level of ppEnk mRNA is developmentally and hormonally regulated in rat ventricular ...
W. C. Claycomb, J. P. Springhorn
core   +1 more source