Results 51 to 60 of about 2,309 (192)
μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks
Annals of Neurology, Volume 98, Issue 4, Page 777-787, October 2025.Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim +6 more
wiley +1 more source
Cell Transplantation, 2006 We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya +3 more
doaj +1 more source
Frontiers in Systems Neuroscience, 2018 The pharmacological agent nitroglycerin (NTG) elicits hyperalgesia and allodynia in mice. This model has been used to study the neurological disorder of trigeminovascular pain or migraine, a debilitating form of hyperalgesia.
Hyeonsoo Jeong +10 more
doaj +1 more source
The Journal of Physiology, Volume 603, Issue 19, Page 5777-5804, October 1, 2025.Abstract figure legend Renal erythropoietin (EPO) production was analysed in anaemic and PHD‐inhibitor‐treated wild‐type mice, and mice with genetic fibroblast‐specific hypoxia‐inducible factor (HIF)‐2 stabilization. We found, that PHD inhibition activated HIF‐2 signalling in interstitial fibroblasts of all kidney zones as observed by the induction of ...
Bettina K. M. Firmke +5 more
wiley +1 more source
Frontiers in Neuroscience, 2018 To investigate dynamic processes of enkephalin (ENK), cholecystokinin octapeptide (CCK-8), orphanin FQ (OFQ) and their receptors (μ opioid receptor, MOR; CCK B type receptor, CCKBR and opioid receptor-like 1 receptor, OPRL1) in the central nerve system ...
Juan Wan +5 more
doaj +1 more source
, 1996 A double-labelling procedure combining immunohistochemical staining with in situ hybridization using a radiolabelled cRNA probe was employed to demonstrate oestrogen receptor-like immunoreactivity and preproenkephalin-A mRNA in the medullary and spinal ...
Amandusson, Åsa, +2 more
core +1 more source
Movement Disorders, Volume 40, Issue 9, Page 1778-1790, September 2025.Abstract Traditionally, clinical trials of putative disease‐modifying therapies in Parkinson's disease have enrolled untreated patients at the earliest clinical stages of their disease. Due to a number of challenges inherent with this approach, there has been a recent move to a different study design, enrolling patients who are already taking “stable ...
M. Maral Mouradian +2 more
wiley +1 more source
Neurobiology of Disease, 2004 Helper virus-free herpes simplex virus (HSV-1) plasmid vectors are an attractive system for gene transfer into neurons in the brain, but promoters that support long-term, neuronal-specific expression are required.
Xiaodan Wang +4 more
doaj +1 more source
, 1999 Middle cerebral artery occlusion may result in increased activation of N-methyl- d-aspartate- or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type receptors by glutamate and lead to neuronal cell death.
L. Belayev +7 more
core +1 more source
, 2022 The olfactory tubercle (OT) is a striatal region that receives olfactory inputs. mRNAs of prodynorphin (Pdyn) and preproenkephalin (Penk), precursors of dynorphins and enkephalins, respectively, are strongly expressed in the striatum. Both produce opioid
Shigeharu Fujieda (188194) +4 more
core +1 more source