Results 71 to 80 of about 2,309 (192)

Chronic naltrexone treatment increases expression of preproenkephalin and preprotachykinin mRNA in discrete brain regions

, 1990
Long-term blockade of brain opioid receptors by the opiate antagonist naltrexone increases methionine-enkephalin content in the striatum and nucleus accumbens (Tempel et al., 1984).
JA Kessler, A Tempel, RS Zukin
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l-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function

Neurobiology of Disease, 2002
In order to assess the role of striatal dopamine (DA) afferents in l-DOPA-induced dyskinesia, we have studied a large series of rats sustaining 2, 3, or 4 unilateral injections of 6-hydroxydopamine (6-OHDA) in the lateral striatum.
Christian Winkler, Deniz Kirik, Anders Björklund, M.Angela Cenci   +3 more
doaj   +1 more source

Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice

Molecular Pain, 2008
Background Mice lacking the preproenkephalin (ppENK) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in ppENK knock-out (KO) mice appeared to occur in supraspinal response to painful ...
Sun Wei-Zen, Cheng Ying-Ying, Chen Tsung-Chieh, Shyu Bai-Chuang   +3 more
doaj   +1 more source

The effect of aging on the response of striatal preproenkephalin and preprotachykinin mRNA contents to chronic haloperidol treatment in rats: Measurement by solution-hybridization RNase protection assay

, 1998
The preproenkephalin (PPeK) and preprotachykinin (PPT) mRNA contents in 3-, 10- and 23-month-old rats in the striatum were measured by solution hybridization-RNase protection assay after 3 weeks of haloperidol injection.
Tang, F, Lau, SM, S.M Lau, F Tang
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Colocalization of oestrogen receptor immunoreactivity and preproenkephalin mRNA expression fo neurons in the superficial laminae of the spinal and medullary dorsal horn of rats

, 1996
A double-labelling procedure combining immunohistochemical staining with in situ hybridization using a radiolabelled cRNA probe was employed to demonstrate oestrogen receptor-like immunoreactivity and preproenkephalin-A mRNA in the medullary and spinal ...
Amandusson, Åsa,, Hermansson, O, Blomqvist, A   +2 more
core  

Overexpression of µ-Opioid Receptors in Peripheral Afferents, but Not in Combination with Enkephalin, Decreases Neuropathic Pain Behavior and Enhances Opioid Analgesia in Mouse

, 2018
Background The current study used recombinant herpes simplex virus type I to increase expression of µ-opiate receptors and the opioid ligand preproenkephalin in peripheral nerve fibers in a mouse model of neuropathic pain.
Brad Peper, Amanda H. Klein, Steven P. Wilson, Sarah Sweitzer, Matthias Ringkamp, Husam K. Mohammad, Srinivasa N. Raja, Rabiah Ali   +7 more
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Preproenkephalin messenger RNA-containing amacrine cells in the chicken retina identified with in situ hybridization histochemistry

, 1995
Enkephalin peptides are present in the retina of several vertebrate species. In the avian retina, enkephalin immunoreactivity is primarily localized to a population of amacrine cells.
BAGNOLI, PAOLA, BRECHA NC, MOLNAR M, DAVIS B, CASINI, GIOVANNI, Paola Bagnoli, Brian M. Davis, Giovanni Casini, Nicholas C. Brecha, Margherita Molnar   +9 more
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Cells expressing preproenkephalin mRNA in the rat pineal gland are not serotonin-producing pinealocytes: evidence using in situ hybridization combined with immunocytochemistry for serotonin

, 1996
1. Preproenkephalin (PPEnk) mRNA expressing cells have been identified in rat pineal gland using radioactive in situ hybridization histochemistry. 2. Approximately 7% of the cells in the pineal gland (7.5 +/- 0.86, mean +/- 95% CI) express PPEnk mRNA ...
Sagen, J, Pappas, G D, Wang, X T, Unnerstall, J R   +3 more
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Localization of preproenkephalin mRNA in rat heart: selective gene expression in left ventricular myocardium

, 1998
The enkephalins are derived from a common precursor protein known as preproenkephalin (ppENK). Enkephalins appear to be one of the endogenous ligands for the opiate receptors. In the rat the ventricular myocardium contains more ppENK mRNA than any other
Gerrit Fleige, Ellen Orthey, Thomas Eschenhagen, Hasso Scholz, Clemens Mittmann, Joachim Weil   +5 more
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Increased expression of c-jun, junB, AP-1, and preproenkephalin mRNA in rat striatum following a single injection of caffeine

, 1995
The effect of a single injection of caffeine on the expression of c- fos, c-jun, junB, and junD, on activator protein 1 (AP-1) and on the levels of preproenkephalin mRNA in rat striatum was studied.
B Johansson, BB Fredholm, P Svenningsson, A Strom, SVENNINGSSON, P, FREDHOLM, BB, STROM, A, JOHANSSON, B   +7 more
core   +1 more source