Results 61 to 70 of about 2,309 (192)
International Endodontic Journal, Volume 58, Issue 8, Page 1126-1145, August 2025.Abstract Background Orthodontic forces may lead to neurogenic inflammation in the dental pulp by triggering the release of somatosensory neuropeptides such as Substance P (SP), Calcitonin gene‐related peptide (CGRP) and Neurokinin A (NKA). In the vast majority of patients, acute symptoms are not triggered, probably due to the control of the neurogenic ...
Javier Caviedes‐Bucheli +7 more
wiley +1 more source
Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus [PDF]
Proceedings of the National Academy of Sciences, 1999 To test the utility of gene therapeutic approaches for the treatment of pain, a recombinant herpes simplex virus, type 1, has been engineered to contain the cDNA for an opioid peptide precursor, human preproenkephalin, under control of the human cytomegalovirus promoter. This virus and a similar recombinant containing the
S P, Wilson +5 more
openaire +2 more sources
Journal of Cellular and Molecular Medicine, Volume 29, Issue 10, May 2025.ABSTRACT Cancer constitutes a significant public health concern, and addressing the challenge of cancer holds paramount importance and requires immediate attention. Epigenetic alterations, encompassing DNA methylation, have emerged as pivotal contributors to the development of diverse cancer types.
Seyed Mohsen Aghaei‐Zarch +2 more
wiley +1 more source
, 1984 International audienceThe messenger RNA (mRNA) coding for the adrenal precursor of enkephalins (preproenkephalin-A) has been detected in bovine adrenal medulla cells using in situ hybridization with 32P-labelled preproenkephalin A (PPA) complementary DNA.
Bloom, Fe +7 more
core +1 more source
Molecular Pain, 2010 Background In pain processing, long term synaptic changes play an important role, especially during chronic pain. The immediate early gene Arc/Arg3.1 has been widely implicated in mediating long-term plasticity in telencephalic regions, such as the ...
Kuhl Dietmar +4 more
doaj +1 more source
European Journal of Neuroscience, Volume 60, Issue 9, Page 6129-6144, November 2024.The GPe regulates information flow in cortico‐basal ganglia‐thalamic circuits. This nucleus relays ascending and descending signals and serves as a central hub within the CBGT network. Abstract For decades, the external globus pallidus (GPe) has been viewed as a passive way‐station in the indirect pathway of the cortico‐basal ganglia‐thalamic (CBGT ...
Cristina Giossi +4 more
wiley +1 more source
Mediators of Inflammation, Volume 2024, Issue 1, 2024.Background. Psoriasis is a noncontagious auto‐inflammatory chronic skin disease. So far, some of the inflammatory genes were upregulated in mouse model of psoriasis. This study examined changes in skin mRNA expression of L‐kynureninase (Kynu), cathelicidin antimicrobial peptide (Camp), beta‐defensin 2 (Defb2), and proenkephalin (Penk) in a mouse model ...
Zahra Emami +8 more
wiley +1 more source
针刺研究, 2010 Objective To observe the effect of acupotomy lysis(AL) on hypothalamic proopiomelanocortin(POMC) mRNA and preproenkephalin(PPE) mRNA expression in rats with the third lumbar vertebrae transverse process syndrome(TLVTPS) so as to study its underlying ...
郭长青 +12 more
doaj +2 more sources
, 2004 The endogenous opioid enkephalin neuropeptides are mediators of pain perception and have been implicated in human addictions. The preproenkephalin gene and its mRNA have also provided many examples of tissue- and species-specific variations in mRNA ...
LaForge, Karl Steven
core +2 more sources
BMC Neuroscience, 2011 Background Enkephalins are endogenous opiates that are assumed to modulate nociceptive information by mediating synaptic transmission in the central nervous system, including the spinal dorsal horn. Results To develop a new tool for the identification of
Kofuji Takefumi +3 more
doaj +1 more source