Results 61 to 70 of about 2,094 (191)

Localization of preproenkephalin mRNA-expressing cells in rat auditory brainstem with in situ hybridization [PDF]

, 1993
Hair cells and auditory nerve dendrites in the inner ear are innervated by pontine neurons that have been demonstrated by immunochemical techniques to contain several neurotransmitters, including acetylcholine and the opioid peptide enkephalins and ...
Landry, Douglas R., Altschuler, Richard A., Hoffman, Douglas W., Hochreiter, Jill S., Treadwell, Melinda D., Brimijoin, Megan R., Gardner, Paul D.   +6 more
core   +1 more source

Presentation_1_Cellular Profiles of Prodynorphin and Preproenkephalin mRNA-Expressing Neurons in the Anterior Olfactory Tubercle of Mice.PDF

, 2022
The olfactory tubercle (OT) is a striatal region that receives olfactory inputs. mRNAs of prodynorphin (Pdyn) and preproenkephalin (Penk), precursors of dynorphins and enkephalins, respectively, are strongly expressed in the striatum. Both produce opioid
Shigeharu Fujieda (188194), Yugo Fukazawa (180184), Koshi Murata (11584171), Ayako Maegawa (13134600), Kazuki Kuroda (3778783)   +4 more
core   +1 more source

Rethinking the external globus pallidus and information flow in cortico‐basal ganglia‐thalamic circuits

European Journal of Neuroscience, Volume 60, Issue 9, Page 6129-6144, November 2024.
The GPe regulates information flow in cortico‐basal ganglia‐thalamic circuits. This nucleus relays ascending and descending signals and serves as a central hub within the CBGT network. Abstract For decades, the external globus pallidus (GPe) has been viewed as a passive way‐station in the indirect pathway of the cortico‐basal ganglia‐thalamic (CBGT ...
Cristina Giossi, Jonathan E. Rubin, Aryn Gittis, Timothy Verstynen, Catalina Vich   +4 more
wiley   +1 more source

Physiological properties of enkephalin-containing neurons in the spinal dorsal horn visualized by expression of green fluorescent protein in BAC transgenic mice

BMC Neuroscience, 2011
Background Enkephalins are endogenous opiates that are assumed to modulate nociceptive information by mediating synaptic transmission in the central nervous system, including the spinal dorsal horn. Results To develop a new tool for the identification of
Kofuji Takefumi, Tsuda Masayuki, Fukushima Teruyuki, Hori Yuuichi   +3 more
doaj   +1 more source

Evaluation of Kynu, Defb2, Camp, and Penk Expression Levels as Psoriasis Marker in the Imiquimod‐Induced Psoriasis Model

Mediators of Inflammation, Volume 2024, Issue 1, 2024.
Background. Psoriasis is a noncontagious auto‐inflammatory chronic skin disease. So far, some of the inflammatory genes were upregulated in mouse model of psoriasis. This study examined changes in skin mRNA expression of L‐kynureninase (Kynu), cathelicidin antimicrobial peptide (Camp), beta‐defensin 2 (Defb2), and proenkephalin (Penk) in a mouse model ...
Zahra Emami, Saeideh Sadat Shobeiri, Razia Khorrami, Navideh Haghnavaz, Mohammad Ali Rezaee, Malihe Moghadam, Safoora Pordel, Mojtaba Sankian, Francesca Zimetti   +8 more
wiley   +1 more source

l-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function

Neurobiology of Disease, 2002
In order to assess the role of striatal dopamine (DA) afferents in l-DOPA-induced dyskinesia, we have studied a large series of rats sustaining 2, 3, or 4 unilateral injections of 6-hydroxydopamine (6-OHDA) in the lateral striatum.
Christian Winkler, Deniz Kirik, Anders Björklund, M.Angela Cenci   +3 more
doaj   +1 more source

Nicotine-induced antinociception, rewarding effects and physical dependence are decreased in mice lacking the preproenkephalin gene

, 2005
It has been shown previously that the endogenous opioid system may be involved in the behavioral effects of nicotine. In the present study, the participation of endogenous enkephalins on nicotine responses has been investigated by using preproenkephalin ...
Mendizábal, Victoria, Maldonado, Rafael, 1961-, Berrendero Díaz, Fernando, 1971-, Bilkei Gorzo, Andras, Robledo, Patricia, 1958-, Galeote González, Lola, Zimmer, Andreas   +6 more
core   +1 more source

Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice

Molecular Pain, 2008
Background Mice lacking the preproenkephalin (ppENK) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in ppENK knock-out (KO) mice appeared to occur in supraspinal response to painful ...
Sun Wei-Zen, Cheng Ying-Ying, Chen Tsung-Chieh, Shyu Bai-Chuang   +3 more
doaj   +1 more source

Enhanced Preproenkephalin-B-Derived Opioid Transmission in Striatum and Subthalamic Nucleus Converges Upon Globus Pallidus Internalis in L-3,4-dihydroxyphenylalanine-Induced Dyskinesia

, 2007
Background: A role for enhanced opioid peptide transmission has been suggested in the genesis of levodopa-induced dyskinesia. However, basal ganglia nuclei other than the striatum have not been regarded as potential sources, and the opioid precursors ...
Dovero, Sandra, Crossman, Alan R., Aubert, Incarnation, Bioulac, Bernard H., Guigoni, Céline, Bloch, Bertrand, Li, Qin, Bezard, Erwan, Gross, Christian E.   +8 more
core   +1 more source

A new species of enkephalin precursor mRNA with a distinct 5′-untranslated region in haploid germ cells [PDF]

, 1989
To elucidate the primary structure of preproenkephalin (A) mRNA expressed by haploid germ cells (round spermatids) in rat testis, we have screened a λgt11 cDNA library for preproenkephalin cDNA inserts.
Akihiro Yamamoto, Yoshikawa, Kazuaki, Takako Aizawa, Maruyama, Kei, Aizawa, Takako, Yamamoto, Akihiro, Kazuaki Yoshikawa, Kei Maruyama   +7 more
core   +1 more source