Results 41 to 50 of about 1,231,815 (285)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

La formación para la investigación en el perfil de carreras de Estomatología de universidades latinoamericanas The research training in the profile of Stomatology careers of Latin American universities

Revista Cubana de Estomatología, 2008
Las universidades constituyen la columna vertebral del subsistema científico-tecnológico de cada país, y por eso les corresponde estimular el espíritu creativo así como la formación científica de los profesionales que forma.
Sol Ángel Rosales Reyes, Orietta Valverde Grandal   +1 more
doaj  

Developing the knowledge-based human resources that support the implementation of the National Dual Training System (NDTS): evaluation of TVET teacher's competency at MARA Training Institutions [PDF]

, 2015
Development in the world of technical and vocational education and training (TVET) on an ongoing basis is a challenge to the profession of the TVET-teachers to maintain their performance.
Ali, Mahazani
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Cloenda

Digithum, 2004
En aquest breu document, el director de la titulació d'Humanitats de la UOC, Miquel Strubell, clou el dossier monogràfic que dimana de la I Jornada sobre les Professions de les Humanitats en la Societat del Coneixement tot destacant aquells eixos de ...
Miquel Strubell
doaj   +1 more source

Model of the professional profile of a class teacher: formats of activity

Вестник Майкопского государственного технологического университета, 2023
Program documents that form the state educational policy in the country, studies of modern educational models and practices prove the priority of solving the problem of educating the younger generation.
Irina Vladimirovna Lebedeva, Anna Aleksandrovna Loshchilova   +1 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Formación Archivística en América Latina: Una revisión de los perfiles y las competencias

Revista Interamericana de Bibliotecología, 2012
In light of today's information society, archival training in Latin America must respond to current demands for a new type of social organization, as well as to the particular contexts and developments in the discipline in different Latin American ...
Sebastián Alejandro Marín Agudelo
doaj  

Assessing the landscape of family medicine in India: A focus on qualification and practice patterns

Journal of Family Medicine and Primary Care
Aims and Objectives: Describe the demographic and professional profiles of the family physicians. 1. To study the factors associated with practice patterns. Methodology: It is a cross-sectional, questionnaire-based study.
Hemavathi Dasappa, Mohan Kubendra, Namiya Jose, Resmi S. Kaimal, Vandana Boobna, S Ramya   +5 more
doaj   +1 more source

Audiological profile of professional disc jockeys

Revista CEFAC, 2020
Purpose: to describe the audiological profile of professional disc jockeys acting in cities of the Brazilian Federal District. Methods: audiometry, tympanometry, transient evoked emissions, and distortion product evoked emissions exams were conducted ...
Roseany Alves da Costa, Dannyelly Torres Araújo, Darlene Cardoso de Souza, Gabriela Guenther Ribeiro Novanta   +3 more
doaj   +2 more sources