Results 51 to 60 of about 6,335,661 (316)
Towards a Law of Invariance in Human Concept Learning [PDF]
, 2011 Invariance principles underlie many key theories in modern science. They provide the explanatory and predictive framework necessary for the rigorous study of natural phenomena ranging from the structure of crystals, to magnetism, to relativistic ...
Vigo, Professor Ronaldo
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Representational information: a new general notion and measure\ud of information [PDF]
, 2011 In what follows, we introduce the notion of representational information (information conveyed by sets of dimensionally defined objects about their superset of origin) as well as an\ud original deterministic mathematical framework for its analysis and ...
Vigo, Professor Ronaldo
core
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Autonom, Behavior, & Moral Goodness [PDF]
, 2003 In this essay, the view that autonomy is always a good is challenged. Numerous examples of autonomous people who committed quite immoral acts are offered.
Thomas, Professor Laurence
core
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Łukasiewicz-Topos Models of Neural Networks, Cell Genome and Interactome Nonlinear Dynamic Models [PDF]
, 2004 A categorical and Łukasiewicz-Topos framework for Algebraic Logic models of nonlinear dynamics in complex functional systems such as Neural Networks, Cell Genome and Interactome Networks is introduced.
Baianu, Professor I.C.
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Revista de Educação Física, 2018 Introdução: O ritmo acelerado de vida dos professores em seu ambiente de trabalho, associado às múltiplas funções desempenhadas, conferem a essa categoria um elevado nível de esforço, sendo considerada uma das profissões com maior vulnerabilidade a ...
Simone Maria Castellano +2 more
doaj +1 more source