Results 161 to 170 of about 907,518 (291)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Future teachers and the self-perception of vocal symptoms and knowledge about vocal health and hygiene. [PDF]

Codas, 2023
Rosa ICB, Dassie-Leite AP, Pereira EC, Martins PDN.   +3 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

EM DEFESA DA FORMAÇÃO DE PROFESSORES COMO SUBÁREA DA EDUCAÇÃO NA ÁRVORE DE CONHECIMENTO DO CNPq

Formação Docente (Associação Nacional de Pós-Graduação e Pesquisa em Educação)
GT 08 FORMAÇÃO DE PROFESSORES ANPED
doaj   +1 more source

ما هو السيكوسوماتيك التحليلي النفسي assistant Professor associate Professor Professor associate Professor Professor

ما هو السيكوسوماتيك التحليلي النفسي؟ العرض الحالي عبارة عن محاولة لتوحيد مجموعة من المفاهيم المربكة النفسية الجسدية التي تطورت حتى الآن. ومن أجل تحقيق هذا الغرض تم تجميع الجوانب المختلفة ومناهج البحث حول خمسة مواضيع رئيسية ، مع الأخذ في الاعتبار التطور النظري للتحليل النفسي من الدافع إلى الأنا التحليل النفسي ومن الفرد إلى الاجتماعي – التحليلي النفسي: 1.
openaire   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Apresentação

Convergência Lusíada, 2017
O número 28 da revista Convergência Lusíada apresenta ao leitor um conjunto heterogêneo de textos sobre autores de diferentes épocas e gêneros, de autoria de pesquisadores brasileiros e portugueses. [...]
Madalena Vaz Pinto
doaj  

التعصب التحليل النفسي لظاهرة مرعبة assistant Professor associate Professor Professor associate Professor Professor

زعزع اعتداء 11 سبتمبر عالم 2001 الوهم المتمثل في أنه في عالم الغد التقني-العقلاني سوف يصبح الحقد التعصبي في عالم الغد التقني-العقلاني عاملاً محسوباً. فمن تفاعل ذهنية متطرفة و أسلحة التدمير الشامل انبثقت سيناريوهات تهديد غير متوقعة. و تبدو اليوم المعالجة الجذرية لجوهر الفكر التعصبي أكثر إلحاحاً من أي وقت مضى.
openaire   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Adolfo Lima e a Introdução do Teatro Escolar Educativo em Portugal

Revista Portuguesa de Educação Artística, 2014
Embora as representações teatrais em estabelecimentos escolares nunca tenham definitivamente acabado, é com a revolução pedagógica iniciada pelo Movimento da Escola Nova que as atividades dramáticas, e as artes em geral, voltam a granjear, desde a Grécia
António Silva
doaj