Results 141 to 150 of about 4,280,758 (253)

Profiles of gifted students through the eyes of their teachers: identifying students at risk for underachievement. [PDF]

Front Child Adolesc Psychiatry
van der Weijden FA, Hornstra L, Kroesbergen EH.   +2 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Veinticinco años recorriendo el camino de la publicación: la historia de vida de la revista Profile

This article presents the life story of Profile. The story is based on an ethnographic case study that aimed to understand the viewpoints of Profile’s new writers and reviewers regarding the role of scientific journals in fostering communities in the ...
Cárdenas, Melba Libia
core   +1 more source

Perceived teacher-student power distance in relation to campus connectedness profiles among Chinese college students: profile differences in difficulties in emotion regulation. [PDF]

Front Psychol
Xing J, Shen Y, Li J, Zhang Y.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Kilkenny alcohol-related harm profile 2019

, 2019
In 2017, Kilkenny was below average for mortality for all ages due to alcohol related causes (53.2 per 100,000 population compared to a National rate of 58.6).
Health Profile Working Group, Cullen, Louise, Goggin, Deirdre, Mason Mohan, Caroline, O'Kane, Joan, O'Donovan, Diarmuid   +5 more
core  

Optimal Vaccination for Contagious Diseases with Seasonal Transmission. [PDF]

Bull Math Biol
Gavish N, Katriel G.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Identifying suicide risk in veterans with criminal-legal system involvement: A latent profile analysis of criminogenic needs and posttraumatic stress symptoms. [PDF]

Psychol Serv
Fortuna AJ, Edwards ER, Cruise KR, Rosenfeld B, Andover MS, Conway CC.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source