Results 131 to 140 of about 4,280,758 (253)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Synthesis and Biological Profile of Substituted Azetidinyl Carbox­amides, A Novel Class of Herbicidal Acyl-ACP Thioesterase Inhibitors

SynOpen
Guido Bojack, David M. Barber, Luke R. Churchman, Christine Dörnbrack, Stephanie Lee, China M. Payne, Luka Posa, Anna M. Reingruber, Dirk Schmutzler, Jens Frackenpohl   +9 more
doaj   +1 more source

Digital Phenotyping of Lifestyle Profiles and Mental Well-Being in German Adults: Prospective Longitudinal Cohort Study. [PDF]

J Med Internet Res
Zhu N, Schoedel R, Sust L, Bühner M, Terhorst Y.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Profiles and transitions of psychological adaptation in AI-assisted Japanese language learning. [PDF]

Front Psychol
Wu Y.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Roscommon alcohol-related harm profile 2019

, 2019
In 2017, Roscommon was above average for mortality for all ages due to alcohol related causes (63.3 per 100,000 population, compared to National 58.6 per 100,000.
Health Profile Working Group, Cullen, Louise, Goggin, Deirdre, Mason Mohan, Caroline, O'Kane, Joan, O'Donovan, Diarmuid   +5 more
core  

Functional impairment profiles and long-term care implications among community health service-managed older adults with disability in China: a latent profile and network analysis study. [PDF]

Front Public Health
Liu R, Chen Y, Niu T, Zhang D, Li Y, Lu Y, Yang D.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Waterford alcohol-related harm profile 2019

, 2019
In 2017, Waterford was above average for mortality for all ages due to alcohol related causes (63.6 per 100,000 population, compared to a National rate of 58.6 per 100,000).
Health Profile Working Group, Cullen, Louise, Goggin, Deirdre, Mason Mohan, Caroline, O'Kane, Joan, O'Donovan, Diarmuid   +5 more
core