Results 151 to 160 of about 4,280,758 (253)

Coach- and Peer-Created Motivational Climate Profiles in Youth Sport: Associations With Enjoyment and Intentions to Continue. [PDF]

Eur J Sport Sci
Jørgensen TM, Abrahamsen FE, Gjesdal S.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Academic self-efficacy and class engagement across Chinese learning motivation profiles among international students in Zhejiang, China. [PDF]

BMC Psychol
Qu Y, Yang X, Zhou X, Dong J.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cork alcohol related harm profile 2019

, 2019
In 2017, Cork had an above average rate for mortality for all ages due to alcohol related causes (70.0 per 100,000 population, National 58.6). In 2017, the percentage of potential years of life lost from selected alcohol related causes was above average ...
Health Profile Working Group, Goggin, Deirdre, Mason Mohan, Caroline, O'Kane, Joan, Cullen, L, O'Donovan, Diarmuid   +5 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Dispensing Patterns of Influenza and Pneumococcal Vaccines in the Private Healthcare Sector in South Africa for 2017 to 2021: A Longitudinal Study. [PDF]

Pharmacoepidemiol Drug Saf
Truter I, Hugo J, Smith H, Bansal S, Vira A.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Accumulative index of published articles in PROFILE Vol. 17 (2015)

, 2015
Journal, PROFILE
core  

Empirical Evidence for the Developmental Origins of Autonomic Stress Regulation: An Attachment Account. [PDF]

Dev Psychobiol
Vacaru SV, Zhu VL, Giridas G, Spiess L, Mazrina A, Waters TEA.   +5 more
europepmc   +1 more source