Results 21 to 30 of about 5,008,337 (326)

MLPAnalyzer: Data Analysis Tool for Reliable Automated Normalization of MLPA Fragment Data

open access: yesCellular Oncology, 2008
Background: Multiplex Ligation dependent Probe Amplification (MLPA) is a rapid, simple, reliable and customized method for detection of copy number changes of individual genes at a high resolution and allows for high throughput analysis.
Jordy Coffa   +5 more
doaj   +1 more source

Multi-Omics Profiling for Health

open access: yesMolecular & Cellular Proteomics, 2023
The world has witnessed a steady rise in both non-infectious and infectious chronic diseases, prompting a cross-disciplinary approach to understand and treating disease.
M. Babu, Michael Snyder
semanticscholar   +1 more source

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review [PDF]

open access: yes, 2011
A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on ...
Akavia   +30 more
core   +2 more sources

Spatial differences in genetic diversity and northward migration suggest genetic erosion along the boreal caribou southern range limit and continued range retraction

open access: yesEcology and Evolution, 2019
With increasing human activities and associated landscape changes, distributions of terrestrial mammals become fragmented. These changes in distribution are often associated with reduced population sizes and loss of genetic connectivity and diversity (i ...
Laura M. Thompson   +3 more
doaj   +1 more source

Comprehensive molecular profiling of lung adenocarcinoma

open access: yesNature, 2014
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic ...
Eric A. Joshua D. Angela N. Alice H. William Juliann Da Collisson Campbell Brooks Berger Lee Chmielecki Be   +356 more
semanticscholar   +1 more source

Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)

open access: yesClinical Infectious Diseases, 2020
Background The emergence of coronavirus disease 2019 (COVID-19) is a major healthcare threat. The current method of detection involves a quantitative polymerase chain reaction (qPCR)–based technique, which identifies the viral nucleic acids when present ...
Li Guo   +21 more
semanticscholar   +1 more source

Spatial profiling of chromatin accessibility in mouse and human tissues

open access: yesNature, 2022
Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context1.
Yanxiang Deng   +18 more
semanticscholar   +1 more source

Assessment of local tissue responses to subcutaneous implantation of Polyetheretherketone and Polymethyl methacrylate-based materials [PDF]

open access: yesScripta Medica
Background/Aim: In surgical dentistry, maxillofacial surgery and traumatology, bone tissue regeneration is one of the most pressing challenges.
Demyashkin Grigory   +7 more
doaj   +1 more source

Highly accurate detection of ovarian cancer using CA125 but limited improvement with serum matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling [PDF]

open access: yes, 2010
Objectives: Our objective was to test the performance of CA125 in classifying serum samples from a cohort of malignant and benign ovarian cancers and age-matched healthy controls and to assess whether combining information from matrix-assisted laser ...
Burford, Brian   +13 more
core   +1 more source

ASF1B Promotes Oncogenesis in Lung Adenocarcinoma and Other Cancer Types

open access: yesFrontiers in Oncology, 2021
Anti-silencing function 1B histone chaperone (ASF1B) is known to be an important modulator of oncogenic processes, yet its role in lung adenocarcinoma (LUAD) remains to be defined. In this study, an integrated assessment of The Cancer Genome Atlas (TCGA)
Wencheng Zhang   +5 more
doaj   +1 more source

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