Results 91 to 100 of about 778,828 (306)

Mesenchymal Stromal Cell-Produced Components of Extracellular Matrix Potentiate Multipotent Stem Cell Response to Differentiation Stimuli

Frontiers in Cell and Developmental Biology, 2020
Extracellular matrix (ECM) provides both structural support and dynamic microenvironment for cells regulating their behavior and fate. As a critical component of stem cell niche ECM maintains stem cells and activates their proliferation and ...
Ekaterina Novoseletskaya, Ekaterina Novoseletskaya, Olga Grigorieva, Peter Nimiritsky, Peter Nimiritsky, Nataliya Basalova, Nataliya Basalova, Roman Eremichev, Irina Milovskaya, Konstantin Kulebyakin, Konstantin Kulebyakin, Maria Kulebyakina, Sergei Rodionov, Nikolai Omelyanenko, Anastasia Efimenko, Anastasia Efimenko   +15 more
doaj   +1 more source

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

Advanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham, Jose Gabriel Castro, Lisette C. Werba, Joseph Amitrano, Luke Fardone, Kevin P. Francis, Anand Ramamurthi, Michael J. Layden, Helen O. McCarthy, Tomas Gonzalez‐Fernandez   +9 more
wiley   +1 more source

Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease

Cell Reports, 2017
The embryonic process of forming a complex structure such as the heart remains poorly understood. Here, we show that Six2 marks a dynamic subset of second heart field progenitors.
Zhengfang Zhou, Jingying Wang, Chaoshe Guo, Weiting Chang, Jian Zhuang, Ping Zhu, Xue Li   +6 more
doaj   +1 more source

Dust Formation in Very Massive Primordial Supernovae

, 2003
At redshift z>5 Type II supernovae (SNII) are the only known dust sources with evolutionary timescales shorter than the Hubble time. We extend the model of dust formation in the ejecta of SNII by Todini & Ferrara (2001) to investigate the same process in
A. Ferrara, Abel, Abel, Bertoldi, Bertoldi, Bromm, Bromm, Bromm, Carilli, Catchpole, Ciardi, Cimatti, Clayton, Clayton, Draine, Dunne, Dwek, Fan, Fryer, Gerardy, Gerardy, Granato, Heger, Hernandez, Hirashita, Hirashita, Hughes, Inoue, Kogut, Kozasa, Kozasa, Kumagai, Ledoux, McCray, Morgan, Moseley, Nakamura, Nakamura, Nozawa, Oh, Omont, Omukai, Omukai, Pettini, Pettini, Prochaska, R. Salvaterra, R. Schneider, Ripamonti, Salvaterra, Scannapieco, Schaye, Schneider, Schneider, Smail, Spergel, Steidel, Tielens, Todini, Umeda, Whittet, Wooden, Woosley   +62 more
core   +2 more sources

Rational Fine‐Tuning of MOF Pore Metrics: Enhanced SO2 Capture and Sensing with Optimal Multi‐Site Interactions

Advanced Functional Materials, EarlyView.
A pore tuning strategy to amplify the multi‐site MOF‐SO2 interactions is proposed to achieve an enhanced trace SO2 capture and chemiresistive sensing in highly stable isostructural DMOFs by annelating benzene rings. This work provides a facile strategy to achieve tailor‐made stable MOF materials for specific multifunctional applications.
Shanghua Xing, Abdulrahman Mohabbat, István Boldog, Jens Möllmer, Marcus Lange, Yulyan Haiduk, Tobias Heinen, Vladimir Pankov, Oliver Weingart, Christoph Janiak   +9 more
wiley   +1 more source

Observational constraints on the progenitor metallicities of core-collapse supernovae

, 2010
We present constraints on the progenitor metallicities of core-collapse supernovae. To date, nearly all metallicity constraints have been inferred from indirect methods such as metallicity gradients in host galaxies, luminosities of host galaxies, or ...
Allende Prieto, Anderson, Anderson, Asplund, Baldwin, Barbon, Barbon, Bartunov, Blaauw, Boissier, Cardelli, Crowther, Eldridge, Eldridge, Filippenko, Filippenko, Garnett, Gaskell, Georgy, Habergham, Hakobyan, Heger, Henry, J. P. Anderson, James, James, Kewley, Kudritzki, Levesque, Levesque, M. Hamuy, Meynet, Modjaz, Mokiem, P. A. James, Pettini, Podsiadlowski, Prantzos, Prieto, Puls, R. A. Covarrubias, S. M. Habergham, Sahu, Schlegel, Smartt, Smartt, Tanaka, Thöne, Tsvetkov, Van Den Bergh, Young   +50 more
core   +2 more sources

Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid

Advanced Functional Materials, EarlyView.
In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang, Lasse Riediger, Qi Rao, Xun Xu, Yan Nie, Yiduo Zhou, Junyao Zhang, Peng Tang, Weiwei Wang, Frank Tacke, Adrien Guillot, Ludovic Vallier, Irene Talon, Wenzhong Li, Yi‐An Yang, Rainer Haag, Nan Ma   +16 more
wiley   +1 more source

Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation

eLife, 2018
Master regulatory genes of tissue specification play key roles in stem/progenitor cells and are often important in cancer. In the prostate, androgen receptor (AR) is a master regulator essential for development and tumorigenesis, but its specific ...
Chee Wai Chua, Nusrat J Epsi, Eva Y Leung, Shouhong Xuan, Ming Lei, Bo I Li, Sarah K Bergren, Hanina Hibshoosh, Antonina Mitrofanova, Michael M Shen   +9 more
doaj   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Novel insights into the ontogeny of basophils

Frontiers in Allergy
Basophils are the least common granulocytes, accounting for <1% of peripheral blood leukocytes. In the last 20 years, analytical tools for mouse basophils have been developed, and we now recognize that basophils play critical roles in various immune ...
Kensuke Miyake, Junya Ito, Hajime Karasuyama   +2 more
doaj   +1 more source