Results 101 to 110 of about 792,725 (355)

The generation and validation of two NKX2-5 fluorescent reporter human embryonic stem cell lines: UMANe002-A-1 and UMANe002-A-2

Stem Cell Research
The transcription factor NKX2-5 is a highly conserved master regulator of heart development which is widely expressed in cardiac progenitors and cardiomyocytes.
M. Douglas, C. O'Loughlin, A.T. Lynch, R. Prialgauskaite, A.D. Adamson, K.M. Dibb, S.J. Kimber, M.J. Birket   +7 more
doaj   +1 more source

Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation

eLife, 2018
Master regulatory genes of tissue specification play key roles in stem/progenitor cells and are often important in cancer. In the prostate, androgen receptor (AR) is a master regulator essential for development and tumorigenesis, but its specific ...
Chee Wai Chua, Nusrat J Epsi, Eva Y Leung, Shouhong Xuan, Ming Lei, Bo I Li, Sarah K Bergren, Hanina Hibshoosh, Antonina Mitrofanova, Michael M Shen   +9 more
doaj   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Novel insights into the ontogeny of basophils

Frontiers in Allergy
Basophils are the least common granulocytes, accounting for <1% of peripheral blood leukocytes. In the last 20 years, analytical tools for mouse basophils have been developed, and we now recognize that basophils play critical roles in various immune ...
Kensuke Miyake, Junya Ito, Hajime Karasuyama   +2 more
doaj   +1 more source

miRNA expression analysis in the human heart: Undifferentiated progenitors vs. bioptic tissues—Implications for proliferation and ageing [PDF]

, 2021
Gioacchin Iannolo, Maria Rita Sciuto, Nicola Cuscino, Claudia Carcione, Claudia Coronnello, Cinzia Maria Chinnici, Giuseppe Maria Raffa, Michele Pilato, Pier Giulio Conaldi   +8 more
openalex   +1 more source

Transparent Inorganic–Organic Bilayer Neural Electrode Array and Integration to Miniscope System for In Vivo Calcium Imaging and Electrophysiology

Advanced Functional Materials, EarlyView.
This study presents the BioCLEAR system, a highly transparent and conductive neural electrode array composed of silver nanowires (AgNWs) and doped PEDOT:PSS, enabling neural recordings with minimal optical artifacts. When integrated with a GRIN lens, this cost‐effective neural implant allows simultaneous electrophysiological recording and GCaMP6‐based ...
Dongjun Han, Kevin Cheng, Swathy Sampath Kumar, Anil Bollimunta, Elizabeth E. Torr, Juhwan Kim, Kyoungmin Kim, Hyungjun Choi, Seongkwon Hwang, Sarah Brodnick, David Cheng, Lindsay Gray, Yei Hwan Jung, William L. Murphy, Aaron J. Suminski, Jonathan J. Nassi, Justin C. Williams, Dong‐Wook Park   +17 more
wiley   +1 more source

Viral encephalitis and seizures cause rapid depletion of neuronal progenitor cells and alter neurogenesis in the adult mouse dentate gyrus

Frontiers in Cellular Neuroscience
Infections impacting the central nervous system (CNS) constitute a substantial predisposing factor for the emergence of epileptic seizures. Given that epilepsy conventionally correlates with hippocampal sclerosis and neuronal degeneration, a potentially ...
Alberto Pauletti, Polina Gurlo, Edna Weiß, Ana Beatriz DePaula-Silva, Karen S. Wilcox, Sonja Bröer   +5 more
doaj   +1 more source

ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis

Cell Reports, 2016
During pancreas development, epithelial buds undergo branching morphogenesis to form an exocrine and endocrine gland. Proper morphogenesis is necessary for correct lineage allocation of pancreatic progenitors; however, the cellular events underlying ...
Hung Ping Shih, Devin Panlasigui, Vincenzo Cirulli, Maike Sander   +3 more
doaj   +1 more source

Microporous Microgel Assemblies Facilitating the Recruitment and Osteogenic Differentiation of Progenitor Cells for Bone Regeneration

Advanced Functional Materials, EarlyView.
There is a significant need for biomaterials with well‐defined stability and bioactivity to support tissue regeneration. In this study, we developed a tunable microgel platform that enables the decoupling of stiffness from porosity, thereby promoting bone regeneration.
Silvia Pravato, Haishuo Guan, Bianca M. Carrara, Mira Jacobs, Matteo Monticelli, Lukas Moser, Thomas Moragues, Andrew J. deMello, Tomaso Zambelli, Martin Ehrbar   +9 more
wiley   +1 more source

Three-dimensional simulations of the interaction between Type Ia supernova ejecta and their main sequence companions

, 2012
The identity of the progenitor systems of SNe Ia is still uncertain. In the single-degenerate (SD) scenario, the interaction between the SN blast wave and the outer layers of a main sequence (MS) companion star strips off H-rich material which is then ...
Edelmann, P., Han, Z. W., Hillebrandt, W., Kromer, M., Liu, Z. W., Pakmor, R., Roepke, F. K., Wang, B.   +7 more
core   +1 more source