Results 31 to 40 of about 792,725 (355)

C/EBP-Induced Transdifferentiation Reveals Granulocyte-Macrophage Precursor-like Plasticity of B Cells

Stem Cell Reports, 2017
The lymphoid-myeloid transdifferentiation potentials of members of the C/EBP family (C/EBPα, β, δ, and ε) were compared in v-Abl-immortalized primary B cells. Conversion of B cells to macrophages was readily induced by the ectopic expression of any C/EBP,
Branko Cirovic, Jörg Schönheit, Elisabeth Kowenz-Leutz, Jelena Ivanovska, Christine Klement, Nina Pronina, Valérie Bégay, Achim Leutz   +7 more
doaj   +1 more source

EVLA Observations Constrain the Environment and Progenitor System of Type Ia Supernova 2011fe

, 2012
We report unique EVLA observations of SN 2011fe representing the most sensitive radio study of a Type Ia supernova to date. Our data place direct constraints on the density of the surrounding medium at radii ~10^15-10^16 cm, implying an upper limit on ...
Alicia M. Soderberg, Badenes, Badenes, Badenes, Berger, Berger, Bianco, Blondin, Bloom, Borkowski, Brown, Brown, Carles Badenes, Carlton, Chen, Chevalier, Chevalier, Chomiuk, Claes Fransson, Colgate, Cowley, Dale, della Valle, Deufel, Di Stefano, Diaz, Hachisu, Hachisu, Hancock, Hayden, Hoopes, Horesh, Hughes, Immler, Jason A. Dittmann, Justham, Kasen, Kelly, Kerzendorf, Laura Chomiuk, Leonard, Liu, Maoz, Margutti, Marietta, Matzner, Maxwell Moe, Michael P. Rupen, Mohamed, Murray, Nakar, Nomoto, Panagia, Patat, Perley, Raffaella Margutti, Raymond, Reynolds, Roger A. Chevalier, Russell, Schaefer, Shappee, Shen, Shen, Shen, Simon, Simon, Soderberg, Walter, Wen-fai Fong, Williams, Williams, Wood-Vasey, Yaron, Zhang   +74 more
core   +1 more source

Observational constraints on the progenitors of core-collapse supernovae : the case for missing high mass stars [PDF]

, 2015
Over the last 15 years, the supernova community has endeavoured to identify progenitor stars of core-collapse supernovae in high resolution archival images of their galaxies.This review compiles results (from 1999 - 2013) in a distance limited sample and
Smartt, S. J.
core   +1 more source

Long term in vitro expansion of epithelial stem cells enabled by pharmacological inhibition of PAK1-ROCK-Myosin II and TGF-β signaling [PDF]

, 2018
Summary: Despite substantial self-renewal capability in vivo, epithelial stem and progenitor cells located in various tissues expand for a few passages in vitro in feeder-free condition before they succumb to growth arrest.
Challberg, Sharon S, Lee, Hyung Joo, McQuiston, Travis J, Pollok, Brian A, Shrivastava, Anura, Wang, Ruipeng, Wang, Ting, Zhang, Chengkang   +7 more
core   +2 more sources

Origin of Basophils and Mast Cells

Allergology International, 2009
Basophils and mast cells are major players in the progression of allergic disorders. Although both cell types originate from hematopoietic stem cells, their lineage commitment pathways and mechanisms have been unsolved issues in hematology.
Yojiro Arinobu, Hiromi Iwasaki, Koichi Akashi   +2 more
doaj   +1 more source

Constraints on the Progenitor of SN 2010jl and Pre-Existing Hot Dust in its Surrounding Medium [PDF]

, 2017
A search for the progenitor of SN~2010jl, an unusually luminous core-collapse supernova of Type~IIn, using pre-explosion {\it Hubble}/WFPC2 and {\it Spitzer}/IRAC images of the region, yielded upper limits on the UV and near-infrared (IR) fluxes from any
Andrews, Jennifer, Arendt, Richard G., Dwek, Eli, Filippenko, Alexei V., Fox, Ori D., Kelly, Patrick L., Shivvers, Isaac, Smith, Nathan, Van Dyk, Schuyler D.   +8 more
core   +2 more sources

Direct and indirect RANK and CD40 signaling regulate the maintenance of thymic epithelial cell frequency and properties in the adult thymus

Frontiers in Immunology
Medullary thymic epithelial cells (mTECs) play a crucial role in suppressing the onset of autoimmunity by eliminating autoreactive T cells and promoting the development of regulatory T cells in the thymus.
Mio Hayama, Mio Hayama, Hiroto Ishii, Hiroto Ishii, Maki Miyauchi, Maki Miyauchi, Masaki Yoshida, Naho Hagiwara, Wataru Muramtatu, Wataru Muramtatu, Kano Namiki, Kano Namiki, Rin Endo, Rin Endo, Takahisa Miyao, Nobuko Akiyama, Nobuko Akiyama, Taishin Akiyama, Taishin Akiyama   +18 more
doaj   +1 more source

A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells

Cell Reports, 2018
Summary: How are closely related lineages, including liver, pancreas, and intestines, diversified from a common endodermal origin? Here, we apply principles learned from developmental biology to rapidly reconstitute liver progenitors from human ...
Lay Teng Ang, Antson Kiat Yee Tan, Matias I. Autio, Su Hua Goh, Siew Hua Choo, Kian Leong Lee, Jianmin Tan, Bangfen Pan, Jane Jia Hui Lee, Jen Jen Lum, Christina Ying Yan Lim, Isabelle Kai Xin Yeo, Chloe Jin Yee Wong, Min Liu, Jueween Ling Li Oh, Cheryl Pei Lynn Chia, Chet Hong Loh, Angela Chen, Qingfeng Chen, Irving L. Weissman, Kyle M. Loh, Bing Lim   +21 more
doaj   +1 more source

Investigating the Andromeda Stream: II. Orbital Fits and Properties of the Progenitor

, 2005
We construct test-particle orbits and simple N-body models that match the properties of the giant stellar stream observed to the south of M31, using the model of M31's potential derived in the companion paper by Geehan et al. (2006).
A. Babul, Binney, Choi, De Rijcke, De Vaucouleurs, Durrell, Durrell, Ferguson, Ferguson, Font, Geehan, Guhathakurta, Ibata, Ibata, Ibata, J. J. Geehan, Johnston, Johnston, Johnston, Landau, Law, M. A. Fardal, Martínez-Delgado, Mateo, McConnachie, McConnachie, Merrett, Merrett, Morrison, P. Guhathakurta, Peebles, Stadel, Stanek, Taylor, Totten, Wadsley, Zucker   +36 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source