Results 61 to 70 of about 792,725 (355)

Black Hole Hyperaccretion Inflow-outflow Model. I. Long And Ultra-long Gamma-ray Bursts

, 2017
Long-duration gamma-ray bursts (LGRBs) and ultra-LGRBs (ULGRBs) originate from collapsars, in the center of which a newborn rotating stellar-mass black hole (BH) surrounded by a massive accretion disk may form.
Gu, Wei-Min, Heger, Alexander, Liu, Tong, Song, Cui-Ying, Zhang, Bing   +4 more
core   +2 more sources

An upper mass limit for the progenitor of the TypeII-P supernova SN1999gi [PDF]

, 2001
Masses and progenitor evolutionary states of TypeII supernovae remain almost unconstrained by direct observations. Only one robust observation of a progenitor (SN1987A) and one plausible observation (SN1993J) are available.
Christopher A. Tout, Colin M. Frayn, Gerard F. Gilmore, Grevesse N., Meynet G., Neil Trentham, Schaller G., Stephen J. Smartt, Vogt N., Walborn N.   +9 more
core   +3 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Categorisation of patients based on immune profiles: a new approach to identifying candidates for response to checkpoint inhibitors

Clinical & Translational Immunology, 2021
Objectives Inhibitors to the checkpoint proteins cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) and programmed cell death protein 1 (PD‐1) are becoming widely used in cancer treatment.
Svetlana Bornschlegl, Michael P Gustafson, Danae A Delivanis, Mabel Ryder, Minetta C Liu, George Vasmatzis, Chris L Hallemeier, Sean S Park, Lewis R Roberts, Ian F Parney, Diane F Jelinek, Allan B Dietz   +11 more
doaj   +1 more source

Identification of the Red Supergiant Progenitor of Supernova 2005cs: Do the Progenitors of Type II-P Supernovae Have Low Mass?

, 2005
The stars that end their lives as supernovae (SNe) have been directly observed in only a handful of cases, due mainly to the extreme difficulty in identifying them in images obtained prior to the SN explosions.
Adam G. Riess, Alexei V. Filippenko, Barbon R., Chugai N. N., Della Valle M., Gal-Yam A., Georgiev T. B., Immler S., Issa M. R., Jean‐Charles Cuillandre, Joshua S. Bloom, Kloehr W., Leaman J., Li W., Li W., Li W., Li W., Mario Livio, Maund J. R., Modjaz M., Munari U., Mutchler M., Saurabh Jha, Schuyler D. Van Dyk, Stathakis R. A., Weidong Li   +25 more
core   +3 more sources

The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells. [PDF]

, 2014
BackgroundIdentification and characterization of molecular controls that regulate mammary stem and progenitor cell homeostasis are critical to our understanding of normal mammary gland development and its pathology.ResultsWe demonstrate that conditional ...
Band, Hamid, Band, Vimla, Edwards, Emily, Kopp, Janel L, Malhotra, Gautam K, Naramura, Mayumi, Sander, Maike, Zhao, Xiangshan   +7 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

The progenitor mass of the magnetar SGR1900+14 [PDF]

, 2009
Magnetars are young neutron stars with extreme magnetic fields (B > 10^{14}-10^{15}G). How these fields relate to the properties of their progenitor stars is not yet clearly established. However, from the few objects associated with young clusters it has
Ben Davies, Bibby, Brand, Christine Trombley, Chryssa Kouveliotou, Davies, Davies, Don F. Figer, Donati, Figer, Figer, Gaensler, Gotthelf, Gotthelf, Hanson, Heger, Helfand, Kaplan, Kouveliotou, Levesque, Messineo, Meynet, Meynet, Muno, Ott, Rolf-Peter Kudritzki, Schaerer, Schaller, Spruit, Stefanie Wachter, Thompson, Thompson, Vink, Vrba   +33 more
core   +2 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Profibrotic potential of Prominin-1⁺ epithelial progenitor cells in pulmonary fibrosis

Respiratory Research, 2011
Background In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures.
Lüscher Thomas F, Beck-Schimmer Beatrice, Matter Christian M, Moch Holger, Stein Sokrates, Germano Davide, Blyszczuk Przemyslaw, Eriksson Urs, Kania Gabriela   +8 more
doaj   +1 more source