Results 81 to 90 of about 792,725 (355)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Adult chondrogenesis and spontaneous cartilage repair in the skate, Leucoraja erinacea

eLife, 2020
Mammalian articular cartilage is an avascular tissue with poor capacity for spontaneous repair. Here, we show that embryonic development of cartilage in the skate (Leucoraja erinacea) mirrors that of mammals, with developing chondrocytes co-expressing ...
Aleksandra Marconi, Amy Hancock-Ronemus, J Andrew Gillis   +2 more
doaj   +1 more source

Constraining the mass of the GRB 030329 progenitor

, 2008
The long-duration gamma-ray burst (GRB) 030329, associated with supernova (SN) 2003dh, occurred inside a star-forming dwarf galaxy at redshift $z=0.1685$.
Anders, Arp, Barker, Bruzual, Calzetti, Clegg R. E. Middlemass, Crockett, Crockett, Davidson, Deng, Dopita, Eldridge, Fagotto, Ferland, Foley, Fruchter, Gal-Yam, Gal-Yam, Galama, Gil de Paz, Gorosabel, Heger, Hirschi, Hjorth, Lejeune, Li, MacFadyen, Magris, Massey, Matheson, Maund, Maund, Mazzali, Mazzali, Maíz-Apellániz, McKee, Meurer, Meynet, Moy, Pastorello, Patat, Pei, Schlegel, Sirianni, Smartt, Smartt, Sokolov, Sollerman, Stanek, Thöne, Wang, Woosley, Woosley, Zackrisson, Zackrisson, Östlin   +55 more
core   +1 more source

The type IIb SN 2008ax: the nature of the progenitor [PDF]

, 2008
A source coincident with the position of the type IIb supernova (SN) 2008ax is identified in pre-explosion Hubble Space Telescope (HST) Wide Field Planetary Camera 2 observations in three optical filters. We identify and constrain two possible progenitor
A. Gal-Yam, A. Pastorello, A. W. Stephens, Aldering, Bastian, Bresolin, Cardelli, Cerviño, Chornock, Crockett, Crockett, D. B. Fox, D. C. Leonard, Dolphin, Dolphin, Drilling, Eldridge, Eldridge, Eldridge, Gal-Yam, Gräfener, Hamann, Hamann, Heger, Holtzman, I. J. Danziger, J. J. Eldridge, J. R. Maund, Jamet, Lee, Leitherer, Lejeune, Li, Li, Li, M. M. Kasliwal, Massey, Massey, Maund, Maund, Maund, Maíz-Apellániz, Maíz-Apellániz, Mostardi, Nakano, Pastorello, Pilyugin, R. M. Crockett, Ryder, Ryder, S. J. Smartt, S. Mattila, Scheepmaker, Smartt, Smith, Turatto, Van Dyk, Östlin   +57 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program

Cell Reports, 2017
Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations cause diverse pathologies, including leukemia. GATA-2-regulated enhancers increase Gata2 expression in hematopoietic stem/progenitor cells and control hematopoiesis.
Charu Mehta, Kirby D. Johnson, Xin Gao, Irene M. Ong, Koichi R. Katsumura, Skye C. McIver, Erik A. Ranheim, Emery H. Bresnick   +7 more
doaj   +1 more source

Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia [PDF]

, 2006
Background— Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of chemoattractant factors such as stromal cell–derived factor 1 and vascular endothelial growth ...
Aicher, A, Dimmeler, S, Heeschen, C, Sasaki, K, Urbich, C, Zeiher, AM   +5 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The Type IIn Supernova SN 2010bt: The Explosion of a Star in Outburst [PDF]

, 2018
Indexación: Scopus.It is well known that massive stars (M > 8 M ) evolve up to the collapse of the stellar core, resulting in most cases in a supernova (SN) explosion.
Benetti, S., Cappellaro, E., Elias-Rosa, N., Ergon, M., Filippenko, A.V., Fox, O.D., Galbany, L., González-Gaitán, S., Kotak, R., Miluzio, M., Monard, L.A.G., Pignata, G., Smith, N., Turatto, M., Van Dyk, S.D.   +14 more
core   +4 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source