Results 41 to 50 of about 569,127 (341)

SCA-1/Ly6A Mesodermal Skeletal Progenitor Subpopulations Reveal Differential Commitment of Early Limb Bud Cells

Frontiers in Cell and Developmental Biology, 2021
At early developmental stages, limb bud mesodermal undifferentiated cells are morphologically indistinguishable. Although the identification of several mesodermal skeletal progenitor cell populations has been recognized, in advanced stages of limb ...
Jessica Cristina Marín-Llera, Carlos Ignacio Lorda-Diez, Juan Mario Hurle, Jesús Chimal-Monroy   +3 more
doaj   +1 more source

Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches. [PDF]

, 2020
The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize genetically defined progenitor subpopulations in live slices across key stages of ...
Arnold, Sebastian J, Daza, Ray Am, Hevner, Robert F, Hodge, Rebecca D, Millen, Kathleen J, Nelson, Branden R, Tripathi, Prem Prakash   +6 more
core   +2 more sources

The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells. [PDF]

, 2014
BackgroundIdentification and characterization of molecular controls that regulate mammary stem and progenitor cell homeostasis are critical to our understanding of normal mammary gland development and its pathology.ResultsWe demonstrate that conditional ...
Band, Hamid, Band, Vimla, Edwards, Emily, Kopp, Janel L, Malhotra, Gautam K, Naramura, Mayumi, Sander, Maike, Zhao, Xiangshan   +7 more
core   +2 more sources

Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair

Bioengineering, 2020
Harnessing adult mesenchymal stem/progenitor cells to stimulate skeletal tissue repair is a strategy that is being actively investigated. While scientists continue to develop creative and thoughtful ways to utilize these cells for tissue repair, the vast
Salomi Desai, Chathuraka T. Jayasuriya
doaj   +1 more source

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

eLife, 2023
Polycomb repressive complex (PRC) 1 regulates stem cell fate by mediating mono-ubiquitination of histone H2A at lysine 119. While canonical PRC1 is critical for hematopoietic stem and progenitor cell (HSPC) maintenance, the role of non-canonical PRC1 in ...
Yaeko Nakajima-Takagi, Motohiko Oshima, Junichiro Takano, Shuhei Koide, Naoki Itokawa, Shun Uemura, Masayuki Yamashita, Shohei Andoh, Kazumasa Aoyama, Yusuke Isshiki, Daisuke Shinoda, Atsunori Saraya, Fumio Arai, Kiyoshi Yamaguchi, Yoichi Furukawa, Haruhiko Koseki, Tomokatsu Ikawa, Atsushi Iwama   +17 more
doaj   +1 more source

Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium [PDF]

, 2013
Background: A defining characteristic of the human intestinal epithelium is that it is the most rapidly renewing tissue in the body. However, the processes underlying tissue renewal and the mechanisms that govern their coordination have proved difficult ...
Ahmed El Hadi, Alyson Parris, Amy Reynolds, Anastasia Sobolewski, Andrea Münsterberg, Barker, Belshaw, Carmon, Chen, Christopher Speakman, Christy Kam, Crawford Jamieson, de Lau, Esther Mitchell, Farin, Farrall, Freeman, Furukawa, Haramis, Hardwick, He, Howe, Howe, James Hernon, Jung, Kaur, Kevin Sargen, Kosinski, Kuhnert, Leedham, Lindqvist, Lopez-Garcia, Loren Bigwood, Mark R Williams, Medema, Michael Lewis, Miyoshi, Munoz, Naohide Oue, Natalia Wharton, Pinto, Playford, Reynolds, Richard Tighe, Richard Wharton, Sandeep Kapur, Sato, Sato, Sato, Scoville, Simmons, Snippert, Suzuki, van de Wetering, van der Flier, van der Flier, van Es, VanDussen, Wataru Yasui, William Stebbings, Yui, Zhao, Zhou, Ziskin   +63 more
core   +1 more source

Differential Responses of Neural Retina Progenitor Populations to Chronic Hyperglycemia

Cells, 2021
Diabetic retinopathy is a frequent complication of longstanding diabetes, which comprises a complex interplay of microvascular abnormalities and neurodegeneration.
Nicole Schmitner, Christina Recheis, Jakob Thönig, Robin A. Kimmel   +3 more
doaj   +1 more source

Search for the preadipocyte progenitor cell [PDF]

Journal of Clinical Investigation, 2006
An increase in adipocyte number is a major contributor to the increase in adipose tissue mass that is characteristic of obesity. The identity and regulation of the adipocyte precursor cell (or preadipocyte) and the preadipocyte precursor cell (or progenitor cell) have been intensely studied for many years.
Gary J. Hausman, Dorothy B. Hausman
openaire   +3 more sources

Long term in vitro expansion of epithelial stem cells enabled by pharmacological inhibition of PAK1-ROCK-Myosin II and TGF-β signaling [PDF]

, 2018
Summary: Despite substantial self-renewal capability in vivo, epithelial stem and progenitor cells located in various tissues expand for a few passages in vitro in feeder-free condition before they succumb to growth arrest.
Challberg, Sharon S, Lee, Hyung Joo, McQuiston, Travis J, Pollok, Brian A, Shrivastava, Anura, Wang, Ruipeng, Wang, Ting, Zhang, Chengkang   +7 more
core   +2 more sources

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

Neural Regeneration Research
Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination. Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve damage.
Jian Yang, Jiang Wu, Xueshun Xie, Pengfei Xia, Jinxin Lu, Jiale Liu, Lei Bai, Xiang Li, Zhengquan Yu, Haiying Li   +9 more
doaj   +1 more source